supported by National Key Research and Development Program of China(2020YFA0908200);National Natural Science Foundation of China(T2225003);National Natural Science Foundation of China(52073060);National Natural Science Foundation of China(61927805);Nanjing Medical Science and Technique Development Foundation(ZKX21019);Clinical Trials from Nanjing Drum Tower Hospital(2022-LCYJ-ZD-01);Natural Science Foundation of Jiangsu Province(BK20180408);Guangdong Basic and Applied Basic Research Foundation(2021B1515120054);Shenzhen Science and Technology Program(JCYJ20210324133214038).
Microneedles have demonstrated value in targeted treatment of dermatosis.Current investigation aims to enhance the functions and optimize substance delivery to improve therapeutic effects.Here,we present innovative sh...
supported from grants from the National Natural Science Foundation of China(No.82102327);Clinical Research Program of 9th People’s Hospital,Shanghai JiaoTong University School of Medicine(No.JYLJ202103)。
Background:Scleroderma is characterized by inflammation and fibrosis,predominantly occurring in the skin and extending to various parts of the body.The pathophysiology of scleroderma is multifaceted,with the current u...
Scleroderma is a rare disease with two primary forms: localized scleroderma (LS) and systemic sclerosis (SSc). Both are chronic conditions that can manifest in various patterns (subtypes) and are linked to extracutane...
Scleroderma (or systemic sclerosis) is a disease characterized by abnormalities in the functioning of small blood vessels and the immune system, ultimately leading to inflammation and excessive fibrosis of the skin an...
Supported by National Natural Science Foundation of China,No.81772103 and No.82172234;Shanghai Clinical Research Center of Plastic and Reconstructive Surgery supported by Science and Technology Commission of Shanghai Municipality,China,No.22MC1940300。
Pathological scarring and scleroderma,which are the most common conditions of skin fibrosis,pathologically manifest as fibroblast proliferation and extracellular matrix(ECM)hyperplasia.Fibroblast proliferation and ECM...
Supported by National Natural Science Foundation of China,No.81704050;National High Level Hospital Clinical Research Funding,No.2022-NHLHCRF-LX-02-0103 and No.2022-NHLHCRF-LX-02-0104.
BACKGROUND Eosinophilic fasciitis(EF)is a rare connective tissue disease that can cause swelling and sclerosis of the extremities,and special attention is needed to differentiate EF from systemic sclerosis.Misdiagnosi...
Scleroderma is a chronic connective tissue disease characterized by inflammation,vascular injury,and progressive skin fibrosis,resulting in significant aesthetic and functional impairments for patients.Current therapi...
Background: Scleroderma is a complex immune-mediated rheumatic disease that is characterized by fibrosis of the skin, internal organs, and vasculopathy. Extensive fibrosis, especially in the limited compartment, has b...
Introduction: Cutaneous manifestations of systemic sclerosis (SSc) include skin ulceration;4% - 12% of patients with SSc develop lower extremity ulcers of various etiologies. Limited data, significant morbidity, and s...