State-of-the-art Review of Metallic Microneedles:Structure,Fabrication,and Application  

作　　者：Zhishan Yuan Hongzhao Zhang Wentao Hu Xiao Yu Si Qin Chengyong Wang Fenglin Zhang 

机构地区：[1]School of Electro-Mechanical Engineering,Guangdong University of Technology,Guangzhou 510006,China [2]Guangdong Provincial Key Laboratory of Minimally Invasive Surgical Instruments and Manufacturing Technology,Guangdong University of Technology,Guangzhou 510006,China [3]State Key Laboratory for High Performance Tools,Guangdong University of Technology,Guangzhou 510006,China [4]Smart Medical Innovation Technology Center,Guangdong University of Technology,Guangzhou 510006,China [5]Department of Dermatology,Guangdong Second Provincial General Hospital,Guangzhou 510006,China

出　　处：《Chinese Journal of Mechanical Engineering》2025年第1期84-105,共22页中国机械工程学报(英文版)

基　　金：Supported by Guangdong Provincial Key-Area Research and Development Program(Grant No.2023B0101200014);Guangdong Provincial Natural Science Foundation(Grant No.2024A1515010440).

摘　　要：Microneedle(MN)is a medical device containing an array of needles with a micrometer-scale.It can penetrate the human stratum corneum painlessly and efficiently for treatment and diagnosis purposes.Currently,the materials commonly used to manufacture MNs include silicon,polymers,ceramics and metals.Metallic MNs(MMNs)have drawn significant attention owing to its superior mechanical properties,machinability,and biocompatibility.This paper is a state-of-the-art review of the structure,fabrication technologies,and applications of MMNs.According to the relative position of the axis of MN and the plane of the substrate,MMNs can be divided into in-plane and out-of-plane.Solid,hollow,coated and porous MMNs are also employed to characterize their internal and surface structures.Until now,numerous fabrication technologies,including cutting tool machining,non-traditional machining,etching,hot-forming,and additive manufacturing,have been used to fabricate MMNs.The recent advances in the application of MMNs in drug delivery,disease diagnosis,and cosmetology are also discussed in-depth.Finally,the shortcomings in the fabrication and application of MMNs and future directions for development are highlighted.

关 键 词：METAL MICRONEEDLES STRUCTURE FABRICATION Application 

分 类 号：TG142.1[一般工业技术—材料科学与工程] TG142[金属学及工艺—金属材料]