Transdermal delivery of natural products against atopic dermatitis  

作　　者：LI Minghui XU Yihua YU Yanan LI Wanshu CHEN Lixia ZHAO Bo GAO Yuli GAO Jianqing LIN Hangjuan 

机构地区：[1]Department of Pharmacy,Ningbo Municipal Hospital of Traditional Chinese Medicine(TCM),Affiliated Hospital of Zhejiang Chinese Medical University,Ningbo 315010,China [2]Institute of Pharmaceutics,College of Pharmaceutical Sciences,Zhejiang University,Hangzhou 310058,China

出　　处：《Chinese Journal of Natural Medicines》2024年第12期1076-1088,共13页中国天然药物(英文版)

基　　金：supported by the NINGBO Medical & Health Leading Academic Discipline Project (No. 2022-ZF02);Ningbo Major Research and Development Plan Project (No.2023Z207)。

摘　　要：Atopic dermatitis(AD) is a chronic inflammatory skin condition. Natural products have gained traction in AD treatment due to their accessibility, low toxicity, and favorable pharmacological properties. However, their application is primarily constrained by poor solubility, instability, and limited permeability. The transdermal drug delivery system(TDDS) offers potential solutions for transdermal delivery, enhanced penetration, improved efficacy, and reduced toxicity of natural drugs, aligning with the requirements of modern AD treatment. This review examines the application of hydrogels, microneedles(MNs), liposomes, nanoemulsions, and other TDDS-carrying natural products in AD treatment, with a primary focus on their effects on penetration and accumulation in the skin. The aim is to provide valuable insights into the treatment of AD and other dermatological conditions.

关 键 词：Transdermal drug delivery system Natural products HYDROGELS MICRONEEDLES Atopic dermatitis Stratum corneum 

分 类 号：R944[医药卫生—药剂学]