CLADRIBINE

作品数：12被引量：11H指数：2
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相关机构：北京农林科学院更多>>
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Cryptotanshinone ameliorates cladribine-induced cognitive impairment in rats
《Asian Pacific Journal of Tropical Biomedicine》2023年第7期296-305,共10页Khadga Raj Aran G.D.Gupta Shamsher Singh 
funded by the Indian Council of Medical Research with Grant Number 2020-8817,New Delhi,India。
Objective:To evaluate the neuroprotective effect of cryptotanshinone against cladribine-induced cognitive impairment in rats.Methods:Rats were administered with cladribine(1 mg/kg,p.o.)and cryptotanshinone(10 and 20 m...
关键词：Alzheimer's disease CLADRIBINE CRYPTOTANSHINONE NEUROTRANSMITTERS NEUROPROTECTIVE Proinflammatory cytokines Cognitive deficit 
Pharmacokinetic Study and Toxicity of Leukovir: A New Combined Drug for the Treatment of Multiple Sclerosis
《Advances in Biological Chemistry》2022年第1期1-15,共15页Elena N. Kalinichenko Irina V. Ponteleeva Marina B. Golubeva 
Leukovir, an enteric-coated tablet, is the original drug product for internal use. The well-known nucleosides cladribine and ribavirin are the active ingredients of the drug product leukovir. Pharmacokinetic parameter...
关键词：Leukovir CLADRIBINE RIBAVIRIN Multiple Sclerosis PHARMACOKINETICS TOXICITY 
Re-induction with modified CLAG regimen in relapsed or refractory acute myeloid leukemia in children bridging to allogeneic hematopoietic stem cell transplantation被引量：8
《World Journal of Pediatrics》2020年第2期152-158,共7页Na Zhang Jing-Bo Shao Hong Li Jing-Wei Yang Kai Chen Jia-Shi Zhu Hui Jiang 
This study was supported by a grant from Shanghai Science and Technology Committee Projects No.14411950602 and No.18ZR1431200.
Background The prognosis for relapsed or refractory acute myeloid leukemia(RR-AML)in children is poor,and the preferred salvage chemotherapy is unclear.One regimen is cladribine,cytarabine,and granulocyte-colony stimu...
关键词：Acute myeloid leukemia CHILDREN CLADRIBINE REFRACTORY RELAPSED 
FDA批准Mavenclad(cladribine/克拉屈滨)治疗多发性硬化症
《广东药科大学学报》2019年第2期214-214,共1页夏训明(编译) 
美国FDA于2019年3月29日批准默克雪兰诺公司(EMD Serono,Inc.)新药Mavenclad(cladribine,克拉屈滨,CAS登记号:4291-63-8)口服片剂用于成人治疗复发性多发性硬化症(multiple sclerosis,MS),包括复发缓解型(relapsing-remitting)多发性硬...
关键词：多发性硬化症 FDA批准 治疗 美国FDA 口服片剂 复发性 CAS 进展型 
Efficacy and safety analysis of the combination of cladribine,cytarabine,granulocyte colony stimulating factor( CLAG ) regime in patients with refractory or relapsed acute myeloid leukemia
《China Medical Abstracts(Internal Medicine)》2016年第3期178-179,共2页段明辉 
Objective To analyze efficacy and safety of CLAG regimen in patients with refractory or relapsed acute myeloid leukemia(AML).Methods Efficacy and adverse events of patients with refractory or relapsed AML who were tre...
关键词：Efficacy and safety analysis of the combination of cladribine cytarabine granulocyte colony stimulating factor AML CLAG regime in patients with refractory or relapsed acute myeloid leukemia ITD 
默克Cladribine片剂营销许可申请获欧洲药品管理局接纳审批
《临床合理用药杂志》2016年第20期26-26,共1页
默克科技公司宣布,欧洲药品管理局（EMA）已接纳审批其试验性药品Cladribine片剂的营销许可申请,将就该药物对于复发缓解型多发性硬化症的治疗作审批。
关键词：默克 CLADRIBINE 生物制药 多发性硬化症 破坏性疾病 资讯网 创先 耐用性 
Systemic mastocytosis: A rare cause of non-cirrhotic portal hypertension
《World Journal of Gastroenterology》2016年第28期6559-6564,共6页Cláudio Martins Cristina Teixeira Suzane Ribeiro Daniel Trabulo Cláudia Cardoso Joao Mangualde Ricardo Freire élia Gamito Ana Luísa Alves Isabelle Cremers Cecília Alves Anabela Neves Ana Paula Oliveira 
Mastocytosis is a clonal neoplastic disorder of the mast cells(MC) that can be limited to the skin(cutaneous mastocytosis) or involve one or more extracutaneous organs(systemic mastocytosis). The clinical manifestatio...
关键词：Systemic mastocytosis Mast cells Non-cirrhotic portal hypertension Upper gastrointestinal bleeding CLADRIBINE 
Developing an Efficient Technology for Key Intermediates Production Used in Enzymatic Synthesis of Cladribine and Nelarabine
《Journal of Chemistry and Chemical Engineering》2014年第9期865-869,共5页Shetnev Anton Andreevich Baykov Sergey Valentinovich Smirnov Alexey Vladimirovich Dorogov Mikhail Vladimirovich Novozhilov Yury Vladimirovich 
The pilot-scale process for preparing 2-amino-6-chloro-9-（2＇,3＇,5＇-tri-O-acetyl-Dq3-ribofuranosyl）-purine and 2-chloroadenosine has been developed with a total yield of the desired compounds 73% and 44.5%, respec...
关键词：NELARABINE CLADRIBINE pharmaceutical intermediate pilot-scale process. 
The intrinsic or the extrinsic pathways of apoptosis in the epidermis after cladribine application?
《Journal of Biomedical Science and Engineering》2013年第3期265-272,共8页Patrycja Chylinska-Wrzos Ewelina Wawryk-Gawda Marta Lis-Sochocka Marian Jedrych Miroslaw Lancut Kamila Bulak Joanna Leszcz-Stankiewicz Barbara Jodlowska-Jedrych 
Purpose: This study was aimed to assess the expression of caspase 8 and caspase 9 in the epidermis, during apoptosis after cladribine administration. Materials and Methods: The experiment was carried on 10 Wistar rats...
关键词：CLADRIBINE APOPTOSIS CASPASE 8 CASPASE 9 EPIDERMIS 
Evaluation of Cladribine treatment in refractory celiac disease type Ⅱ被引量：1
《World Journal of Gastroenterology》2011年第4期506-513,共8页Greetje J Tack Wieke HM Verbeek Abdul Al-Toma Dirk J Kuik Marco WJ Schreurs Otto Visser Chris JJ Mulder 
Supported by An Unrestricted Grant from Astra Zeneca
AIM: To evaluate cladribine [2-chlorodeoxyadenosine (2-CdA)] therapy in refractory celiac disease (RCD) Ⅱ. METHODS: An open-label cohort-study of RCD Ⅱ patients treated with 2-CdA was performed between 2000 and 2010...
关键词：CLADRIBINE Refractory celiac disease Clinical course Enteropathy associated T-cell lymphoma SURVIVAL 
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