supported by grants from the General Project of the National Natural Science Foundation of China(No.81970180);the Science and Technology Project of Tianjin Municipal Health Committee(No.TJWJ2022QN030);the Key projects of Tianjin Applied Basic Research and Multi-Investment Fund(No.21JCZDJC01240);the Science and Technology Project of Tianjin Municipal Health Committee(No.TJWJ2022XK018);Tianjin Key Medical Discipline(Specialty)Construction Project(No.TJYXZDXK-056B);Tianjin Municipal Natural Science Foundation(No.22JCQNJC00820);Tianjin Health Research Project(No.TJWJ2023QN027);Tianjin Health Bureau Project(No.ZC20074);Tianjin Key Medical Discipline(Specialty)Construction Project(No.TJWJ2023XK010);Henan Provincial Youth and Middle-aged Health Science and Technology Talents Excellent Youth Program(No.20230273).
To the Editor:After chimeric antigen receptor T(CAR-T)cell therapy,over 90%of patients experience either mild or severe cytopenia,with the prevalence of Grades 3–4 neutropenia ranging from 53%to 94.3%.[1,2]Granulocyt...
Introduction: Relapsed Congenital Talipes Equino Varus (CTEV) refers to clubfoot diagnosed after walking age. We refer to this entity as residual deformities of a previously treated clubfoot or a complete recurrence f...
Introduction There is currently no standard treatment for relapsed and arsenic trioxide(ATO)-resistant acute promyelocytic leukemia(APL).Here,we report a case series of realgar-indigo naturalis formula(RIF)for the suc...
funded by Beijing Physician Scientist Training Project(No.BJPSTP-2024-01)to Liang Wang.
Natural killer/T cell lymphoma(NKTCL)is a malignant tumor originating from NK or T cells,characterized by its highly aggressive and heterogeneous nature.NKTCL is predominantly associated with Epstein-Barr virus infect...
supported by the National Natural Science Foundation of China to H.Z.(Grant Nos.81770184,81970143,and 82270167)and L.Z.(Grant No.81800174);the Talent Young Program of Guangdong Province(2021B1515020017),and the Leading Talents Program from The First Affiliated Hospital of Jinan University to H.Z.
Acute myeloid leukemia(AML)is a common hematological malignancy with overall poor prognosis.Exploring novel targets is urgent and necessary to improve the clinical outcome of relapsed and refractory(RR)AML patients.Th...
National Natural Science Foundation of China,Grand/Award Numbers:81970583 and 82060138;the Natural Science Foundation of Jiangxi Province,Grand/Award Number:20202BABL206025;Kidney Disease Engineering Technology Research Centre Foundation of Jiangxi Province,Grand/Award Number:20164BCD40095.
Background:Minimal change disease(MCD)following coronavirus disease 2019(COVID-19)vaccination has been increasingly reported;however,the clinical characteristics and pathogenesis of patients with MCD have not been tho...
National Natural Science Foundation of China(Nos.81770166,81700193,82170186,and 81720108002);Jiangsu Province’s Medical Elite Programme(No.ZDRCA2016022);Project of the National Key Clinical Specialty,the Jiangsu Provincial Special Program of Medical Science(No.BE2017751);National Science and Technology Major Project(No.2018ZX09734007);China Postdoctoral Science Foundation(No.2021M691336);Jiangsu Postdoctoral Science Foundation(No.2021K083A)
Background:Although the treatment of peripheral T-cell lymphoma(PTCL)has undergone advancements during the past several years,the response rate and long-term effects with respect to patients with PTCL remain unsatisfa...
supported by the National Natural Science Foundation of China(grant numbers 82170188 and 81970176);Guangdong Basic and Applied Basic Research Foundation(grant number 2021A1515110012).
Anti-PD-1 antibodies are a favorable treatment for relapsed or refractory extranodal natural killer T cell lymphoma(RR-ENKTL),however,the complete response(CR)rate and the duration of response(DOR)need to be improved....
Objective To investigate the safety and efficacy of donor-derived CD19+or sequential CD19+CD22+chimeric antigen receptor T-cell(CAR-T)therapy in patients with B-cell acute lymphoblastic leukemia(BALL)afterallogeneic h...