Granulocyte colony-stimulating factor in neutropenia management after CAR-T cell therapy:A safety and efficacy evaluation in refractory/relapsed B-cell acute lymphoblastic leukemia  

作　　者：Xinping Cao Meng Zhang Ruiting Guo Xiaomei Zhang Rui Sun Xia Xiao Xue Bai Cuicui Lyu Yedi Pu Juanxia Meng Huan Zhang Haibo Zhu Pengjiang Liu Zhao Wang Yu Zhang Wenyi Lu Hairong Lyu Mingfeng Zhao 

机构地区：[1]First Center Clinic College of Tianjin Medical University,Tianjin 300070,China [2]School of Medicine,Nankai University,Tianjin 300071,China [3]Department of Hematology,Tianjin First Central Hospital,Tianjin 300392,China [4]Department of Hematology,Henan Provincial People’s Hospital,People’s Hospital of Zhengzhou University,Zhengzhou,Henan 450003,China

出　　处：《Chinese Medical Journal》2025年第1期111-113,共3页中华医学杂志(英文版)

基　　金：supported by grants from the General Project of the National Natural Science Foundation of China(No.81970180);the Science and Technology Project of Tianjin Municipal Health Committee(No.TJWJ2022QN030);the Key projects of Tianjin Applied Basic Research and Multi-Investment Fund(No.21JCZDJC01240);the Science and Technology Project of Tianjin Municipal Health Committee(No.TJWJ2022XK018);Tianjin Key Medical Discipline(Specialty)Construction Project(No.TJYXZDXK-056B);Tianjin Municipal Natural Science Foundation(No.22JCQNJC00820);Tianjin Health Research Project(No.TJWJ2023QN027);Tianjin Health Bureau Project(No.ZC20074);Tianjin Key Medical Discipline(Specialty)Construction Project(No.TJWJ2023XK010);Henan Provincial Youth and Middle-aged Health Science and Technology Talents Excellent Youth Program(No.20230273).

摘　　要：To the Editor:After chimeric antigen receptor T(CAR-T)cell therapy,over 90%of patients experience either mild or severe cytopenia,with the prevalence of Grades 3–4 neutropenia ranging from 53%to 94.3%.[1,2]Granulocyte colony-stimulating factor(G-CSF),known for its ability to enhance the proliferation and differentiation of neutrophils,has been extensively employed for the prevention and treatment of neutropenia in various contexts.However,its application in patients with refractory/relapsing B-cell acute lymphoblastic leukemia(R/R B-ALL)after CAR-T cell therapy remains a topic of debate.[3]Several studies have suggested that G-CSF may exert anti-inflammatory effects by modulating the release of inflammatory factors,such as interleukin-12(IL-12),TNF-α,and IFN-γ,or by influencing the differentiation of T-cell subsets.[4]However,other researchers have posited that G-CSF could exacerbate cytokine release syndrome(CRS)and immune effector cell-associated neurotoxicity syndrome(ICANS)through the augmentation of antigen-presenting cell function.

关 键 词：anti inflammatory effects efficacy cytokine release syndrome chimeric antigen receptor T cell therapy NEUTROPENIA granulocyte colony stimulating factor 

分 类 号：R733.71[医药卫生—肿瘤]