BACKGROUND Cytomegalovirus(CMV)prophylaxis with valganciclovir and ganciclovir is associated with elevated neutropenia and leukopenia risk in kidney transplant recipients,although the impact of these events on healthc...
supported by grants from the General Project of the National Natural Science Foundation of China(No.81970180);the Science and Technology Project of Tianjin Municipal Health Committee(No.TJWJ2022QN030);the Key projects of Tianjin Applied Basic Research and Multi-Investment Fund(No.21JCZDJC01240);the Science and Technology Project of Tianjin Municipal Health Committee(No.TJWJ2022XK018);Tianjin Key Medical Discipline(Specialty)Construction Project(No.TJYXZDXK-056B);Tianjin Municipal Natural Science Foundation(No.22JCQNJC00820);Tianjin Health Research Project(No.TJWJ2023QN027);Tianjin Health Bureau Project(No.ZC20074);Tianjin Key Medical Discipline(Specialty)Construction Project(No.TJWJ2023XK010);Henan Provincial Youth and Middle-aged Health Science and Technology Talents Excellent Youth Program(No.20230273).
To the Editor:After chimeric antigen receptor T(CAR-T)cell therapy,over 90%of patients experience either mild or severe cytopenia,with the prevalence of Grades 3–4 neutropenia ranging from 53%to 94.3%.[1,2]Granulocyt...
Kostmann syndrome, or severe congenital neutropenia, is a rare condition in children marked by a neutrophil count of less than 500/mm3. This congenital agranulocytosis, an autosomal recessive genetic disorder, is ofte...
supported by Guangdong Basic and Applied Basic Research Foundation(2024B1515040019);the National Natural Science Foundation of China(32161160326,32270875,and 32370874);the National Key R&D Program of China(2023YFA1800100);the Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme(2019).
Cancer is a major global health issue;in 2020,there were 19.29 million new cancer cases and 9.96 million cancer deaths worldwide(Siegel et al.,2023).Despite ongoing research,chemotherapy remains the primary treatment ...
supported by The Beijing Heathco Clinical Oncology Research Foundation(Y-SY201901-0198).
Objective The efficacy and safety of different doses of PEG recombinant human granulocyte colony-stimulating factor(PEG-rhG-CSF)in the prevention of leukopenia/neutropenia during concurrent chemoradiotherapy for cervi...
Neutropenia is definedas an absolute neutrophil count(ANC)of less than 1500/μL.According to the number of circulating neutrophils,neutropenia is divided into mild(1000/μL≤ANC<1500/μL),mode rate(500/μL≤ANC<1000/...
Objective:To compare the efficacy and safety of pegylated recombinant human granulocyte colony-stimulating factor(PEG-rhG-CSF)for preventive or delayed treatment in neutropenia,completion rate of concurrent chemoradio...
Background and Aims:Cirrhosis patients exhibit cyto-penia,and,at times refractory neutropenia to granulocyte colony-stimulating factor(G-CSF),which acts through the CSF3-receptor(CSF3R),and changes in CSF3R can affect...
BACKGROUND Percutaneous endoscopic gastrostomy with jejunal extension(PEG-J)is often used to treat patients with neurological impairment and difficulty in swallowing.However,these patients often develop copper deficie...
BACKGROUND Japanese encephalitis virus(JEV),a mosquito borne flavivirus,is the leading cause of viral encephalitis in Asia,in terms of frequency and severity.JEV infection is thought to confer lifelong immunity.With t...