Agranulocytosis following injection of inactivated Japanese encephalitis vaccine(Vero cell):A case report  

作　　者：Li Wang Xu Zhang Yan-Tao Liu 

机构地区：[1]Department of Pharmacy,West China Second University Hospital,Sichuan University/Evidence-Based Pharmacy Center,West China Second University Hospital,Sichuan University/Key Laboratory of Birth Defects and Related Diseases of Women and Children,Sichuan University,Ministry of Education,Chengdu 610041,Sichuan Province,China [2]Department of Pharmacy,West China Second University Hospital,Sichuan University/Evidence-Based Pharmacy Center,West China Second University Hospital,Sichuan University/Key Laboratory of Birth Defects and Related Diseases of Women and Children,Sichuan University,Ministry of Education,Chengdu 610041,Sichuan Province,China/Department of Pharmacy,Dechang People's Hospital,Liangshan 615500,Sichuan Province,China

出　　处：《World Journal of Clinical Cases》2021年第25期7468-7471,共4页世界临床病例杂志

摘　　要：BACKGROUND Japanese encephalitis virus(JEV),a mosquito borne flavivirus,is the leading cause of viral encephalitis in Asia,in terms of frequency and severity.JEV infection is thought to confer lifelong immunity.With the near eradication of poliomyelitis,JEV is now the continent’s leading cause of childhood viral neurologic infection and disability.The most common clinical manifestation of JEV infection is acute encephalitis,and currently there is no specific antiviral therapy.Japanese Encephalitis Vaccine(JE-VC)is an effective prevention measure,including JE-VC,Live(JE-MB),and Inactivated JE-VC.CASE SUMMARY A 9-mo-old girl received injection of Inactivated JE-VC(Vero cell)(Liaoning Chengda,batch number 201611B17)on August 31,2017.On that night,she developed a fever with the body temperature up to 38.5°C,for which Ibuprofen Suspension Drops 1.25 mL was given as antipyretic treatment.On September 1,the patient developed apocleisis,and her parents noticed herpes in her oral cavity.The patient was sent to our hospital on September 3.Physical examination led to a diagnosis of herpetic stomatitis,for which Stomatitis Spray 1 puff,tid,Kangfuxin Liquid 2 mL,tid,and vitamin B20.5 tablet,tid,were prescribed.Routine blood tests for low fever on September 6,2017 revealed an absolute neutrophil count(ANC)of 0.62×109/L,hemoglobin(Hb)of 109 g/L,and platelet count(PLT)of 308×10^(12)/L,and the tests were monitored regularly thereafter.The patient was followed until July 26,2020,when routine blood tests revealed ANC 1.72×109/L,Hb 138 g/L,and PLT 309×1012/L,indicating that the neutropenia count had normalized.CONCLUSION This report attempts to bring to clinical attention that Inactivated JE-VC(Vero cell)might cause prolonged granulocytopenia or even agranulocytosis.

关 键 词：Inactivated Japanese Encephalitis Vaccine(Vero cell) NEUTROPENIA AGRANULOCYTOSIS Japanese Encephalitis virus Case report 

分 类 号：R186[医药卫生—流行病学] R557.3[医药卫生—公共卫生与预防医学]