Resistance mechanisms and potential therapeutic strategies in relapsed or refractory natural killer/T cell lymphoma  

作　　者：Chengji Wang Liang Wang 

机构地区：[1]Department of Hematology,Beijing Tongren Hospital,Capital Medical University,Beijing 100730,China

出　　处：《Chinese Medical Journal》2024年第19期2308-2324,共17页中华医学杂志(英文版)

基　　金：funded by Beijing Physician Scientist Training Project(No.BJPSTP-2024-01)to Liang Wang.

摘　　要：Natural killer/T cell lymphoma(NKTCL)is a malignant tumor originating from NK or T cells,characterized by its highly aggressive and heterogeneous nature.NKTCL is predominantly associated with Epstein-Barr virus infection,disproportionately affecting Asian and Latin American populations.Owing to the application of asparaginase and immunotherapy,clinical outcomes have improved significantly.However,for patients in whom first-line treatment fails,the prognosis is exceedingly poor.Overexpression of multidrug resistance genes,abnormal signaling pathways,epigenetic modifications and active Epstein-Barr virus infection may be responsible for resistance.This review summarized the mechanisms of resistance for NKTCL and proposed potential therapeutic approaches.

关 键 词：Natural killer/T cell lymphoma Epstein-Barr virus Chemotherapy resistance ASPARAGINASE IMMUNOTHERAPY 

分 类 号：R73[医药卫生—肿瘤]