云南高校图书馆联盟文献共享服务平台- ASPARAGINASE

ASPARAGINASE: 作品数：12被引量：5H指数：2; 导出分析报告; 相关领域：医药卫生生物学更多>>; 相关作者：陈建华吴梧桐更多>>; 相关机构：中国药科大学更多>>; 相关期刊：《Chinese Medical Journal》《World Journal of Gastrointestinal Endoscopy》《Animal Nutrition》《World Journal of Emergency Medicine》更多>>; 相关基金：上海市自然科学基金更多>>

Induction of Cyp2e1 contributes to asparaginase-induced hepatocyte sensitization to lipotoxicity: 《Acta Pharmaceutica Sinica B》2025年第2期963-972,共10页Yin Zhu Yuyin Wang Keito Hoshitsuki Da Yang Lauren Kokai Xiaochao Ma Wen Xie Christian A.Fernandez; supported by the University of Pittsburgh School of Pharmacy and NIH Grants R01CA216815 and R01DK140079(USA).; One of the leading therapies for acute lymphoblastic leukemia(ALL)is the chemotherapeutic agent PEGylated E.coli-derived-l-asparaginase(PEG-ASNase).Due to the high risk of dose-limiting liver injury,characterized by c...; 关键词：Liver injury ASPARAGINASE LIPOLYSIS LIPOTOXICITY Oxidative stress ATGL CYP2E1

Resistance mechanisms and potential therapeutic strategies in relapsed or refractory natural killer/T cell lymphoma: 《Chinese Medical Journal》2024年第19期2308-2324,共17页Chengji Wang Liang Wang; funded by Beijing Physician Scientist Training Project(No.BJPSTP-2024-01)to Liang Wang.; Natural killer/T cell lymphoma(NKTCL)is a malignant tumor originating from NK or T cells,characterized by its highly aggressive and heterogeneous nature.NKTCL is predominantly associated with Epstein-Barr virus infect...; 关键词：Natural killer/T cell lymphoma Epstein-Barr virus Chemotherapy resistance ASPARAGINASE IMMUNOTHERAPY

Transient Diabetes Induced by L-Asparaginase: 《Open Journal of Pediatrics》2023年第6期862-865,共4页Mamadou Moustapha Diop M’mah Aminata Bangoura Aissata Barry Emmanuel Camara Kolié Ouo Ouo Pé Neabei Beimy Mohamed Lamine Diallo Kaba Bangoura Moustapha Kouyate Mohamed Lamine Kaba Aka Nbga; Background: Although hyperglycaemia is one of the known side effects of L-asparaginase, its contribution to the development of diabetic ketoacidosis (DKA) is less well known in the literature. Asparaginase is an essen...; 关键词：ASPARAGINASE DIABETES ALL Donka

Efficacy and safety of endoscopic retrograde cholangiopancreatography in recurrent pancreatitis of pediatric asparaginase-associated pancreatitis: 《World Journal of Gastrointestinal Endoscopy》2023年第10期614-622,共9页Kai-Hua Yang Jing-Qing Zeng Sheng Ding Tian-Ao Zhang Wen-Yu Wang Jia-Yu Zhang Lan Wang Jian Xiao Biao Gong Zhao-Hui Deng; the Science and Technology Commission of Shanghai Municipality of China,No.22Y11921800.; BACKGROUND Asparaginase(ASP)is an important drug in combined chemotherapy regimens for pediatric acute lymphoblastic leukemia(ALL);ASP-associated pancreatitis(AAP)is the main adverse reaction of ASP.Recurrent pancreat...; 关键词：Acute lymphoblastic leukemia ASPARAGINASE Endoscopic retrograde cholangiopancreatography Pancreatic pseudocyst Recurrent pancreatitis CHILDREN

Asparaginase-associated pancreatitis in chemotherapytreated pediatric patients:a five-year retrospective study: 《World Journal of Emergency Medicine》2022年第4期313-321,共9页Chen-xi Liu Yun-yu Zhang Qiu-shi Yang Shu-hong Shen Jing Chen Yan-jing Tang Chang-cheng Chen Zhuo Wang Bi-ru Li Juan Qian Ying Wang Wen-ting Hu Bo-tao Ning; Shanghai Natural Science Foundation(No.19ZR1432900)supported this study.; Asparaginase(Asp)represents a key agent in induction remission for acute lymphoblastic leukemia(ALL)and certain subtypes of non-Hodgkin lymphoma(NHL).By catalyzing the hydrolysis of extracellular asparagine,thus deple...; 关键词：REGIMEN ACUTE PANCREATITIS

Mechanistic studies of PEG-asparaginase-induced liver injury and hepatic steatosis in mice: 《Acta Pharmaceutica Sinica B》2021年第12期3779-3790,共12页Gundala Venkata Naveen Kumar Keito Hoshitsuki Sanjay Rathod Manda J.Ramsey Lauren Kokai Erin E.Kershaw Wen Xie Christian A.Fernandez; supported by the National Institutes of Health grants CA216815 and TL1TR001858(USA);the Pittsburgh Liver Research Center,Rho Chi Society;American Foundation for Pharmaceutical Education(USA);the University of Pittsburgh School of Pharmacy(USA)。; PEGylated-L-asparaginase(PEG-ASNase)is a chemotherapeutic agent used to treat pediatric acute lymphoblastic leukemia(ALL).Its use is avoided in adults due to its high risk of liver injury including hepatic steatosis,w...; 关键词：Liver injury LEUKEMIA ASPARAGINASE LIPOLYSIS Adverse drug reaction Adipose tissue Hepatic steatosis Amino acid response

Pharmacogenetics of asparaginase in acute lymphoblastic leukemia被引量：2: 《Cancer Drug Resistance》2019年第2期242-255,共14页Rachid Abaji Maja Krajinovic; The authors would like to thank the Charles Bruneau Foundation for the constant support;Krajinovic M currently holds grants from Cancer Research Society and the Network of Applied Medical Genetics(RMGA)。; Asparaginase is a key component in leukemias and lymphomas treatment protocols and is suggested as a treatment for other malignancies in which an amino acid depletion strategy is indicated.Asparaginase intolerance is ...; 关键词：ASPARAGINASE PHARMACOGENOMICS hypersensitivity reactions PANCREATITIS RELAPSE acute lymphoblastic leukemia adverse drug reactions

PEG-asparaginase in BFM-90 regimen improves outcomes in adults with newly diagnosed lymphoblastic lymphoma被引量：3: 《Chinese Journal of Cancer Research》2017年第1期66-74,共9页Wen Zheng Hanyun Ren Xiaoyan Ke Mei Xue Yongqing Zhang Yan Xie Ningjing Lin Meifeng Tu Weiping Liu Lingyan Ping Zhitao Ying Chen Zhang Lijuan Deng Xiaopei Wang Yuqin Song Jun Zhu; Objective： Although L-asparaginase（L-ASP） is a standard treatment for lymphoblastic lymphoma（LBL）,hypersensitivity reactions by some patients limit its application. Polyethylene glycol-conjugated asparaginase（PE...; 关键词：PEG-asparaginase lymphoblastic lymphoma treatment

Pegylated Asparaginase用于儿童急性淋巴细胞白血病有获益: 《中国执业药师》2016年第2期45-45,共1页; 《柳叶刀肿瘤学》杂志于2015年12月第16卷第16期发布了一项关于比较静脉注射用Pegylated Asparaginase（参考译名：聚乙二醇修饰门冬酰胺酶）和肌内注射用原始大肠埃希菌门冬酰胺酶（通用名：Asparaginase）用于新近诊断的儿童急性淋巴...; 关键词：门冬酰胺酶大肠埃希菌肌内注射聚乙二醇修饰柳叶刀 Ⅲ期临床试验肿瘤学卷第酶半衰期试验结果

Homeostatic responses to amino acid insufficiency: 《Animal Nutrition》2015年第3期135-137,共3页Tracy G.Anthony; funding by the National Institutes of Health grant HD070487;the New Jersey Agricultural Extension Station and USDA NIFA NC1184 in support of work described in this article; This article provides a brief overview describing how two key signaling pathways, namely the integrated stress response and the mammalian target of rapamycin complex 1, work together to facilitate cellular adaptation ...; 关键词：MTOR GCN2 Integrated stress response ASPARAGINASE Eukaryotic initiation factor 2 Activating transcription factor 4

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