LIPOLYSIS

作品数：63被引量：211H指数：8
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相关作者：胡霞于游杨晓改刘竟成丁仁博更多>>
相关机构：北京大学浙江大学澳门大学南京医科大学第二附属医院更多>>
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Induction of Cyp2e1 contributes to asparaginase-induced hepatocyte sensitization to lipotoxicity
《Acta Pharmaceutica Sinica B》2025年第2期963-972,共10页Yin Zhu Yuyin Wang Keito Hoshitsuki Da Yang Lauren Kokai Xiaochao Ma Wen Xie Christian A.Fernandez 
supported by the University of Pittsburgh School of Pharmacy and NIH Grants R01CA216815 and R01DK140079(USA).
One of the leading therapies for acute lymphoblastic leukemia(ALL)is the chemotherapeutic agent PEGylated E.coli-derived-l-asparaginase(PEG-ASNase).Due to the high risk of dose-limiting liver injury,characterized by c...
关键词：Liver injury ASPARAGINASE LIPOLYSIS LIPOTOXICITY Oxidative stress ATGL CYP2E1 
Lacticaseibacillus paracasei K56 inhibits lipid accumulation in adipocytes by promoting lipolysis
《Food Science and Human Wellness》2024年第6期3511-3521,共11页Silu Wang Jinxing Li Wei-Hsien Liu Niya Li Huijing Liang Weilian Hung Qiuyue Jiang Ruyue Cheng Xi Shen Fang He 
supported by the Yili Industrial Group Co., Ltd., and National Natural Science Foundation of China (81973042).
Probiotics crosstalk immunity to improve host glycolipid metabolism,which is a new strategy for obesity.This study aimed to explore the functions of Lacticaseibacillus paracasei K56(K56),in regulating the lipid metabo...
关键词：OBESITY Lacticaseibacillus MACROPHAGE ADIPOCYTE LIPOLYSIS 
Lipolysis pathways modulate lipid mediator release and endocannabinoid system signaling in dairy cows'adipocytes
《Journal of Animal Science and Biotechnology》2024年第6期2366-2382,共17页Madison N.Myers Miguel Chirivi Jeff C.Gandy Joseph Tam Maya Zachut G.Andres Contreras 
funded by the Michigan Animal Agricultural Alliance competitive project#AA-23–0014;United States Department of Agriculture National Institute of Food and Agriculture(USDA)projects#2019–67015-29443 and#2021–67037-34657;the United States-Israel Binational Agricultural Research Development(BARD)Fund project#IS-5167–19;the Office for the Associate Dean of Research at Michigan State University;supported by USDA National Institute of Food and Agriculture’s Agriculture and Food Research Initiative Educational Workforce and Development Program award#2024-67011-42947。
Background As cows transition from pregnancy to lactation,free fatty acids(FFA)are mobilized from adipose tissues(AT)through lipolysis to counter energy deficits.In clinically healthy cows,lipolysis intensity is reduc...
关键词：Adipose tissue Dairy cows Endocannabinoid system ENDOCANNABINOIDS LIPOLYSIS 
Mechanism of Metabolic Dysfunction-associated Steatotic Liver Disease:Important role of lipid metabolism
《Journal of Clinical and Translational Hepatology》2024年第9期815-826,共12页Xiaoxi Feng Rutong Zhang Zhenye Yang Kaiguang Zhang Jun Xing 
supported by the Research Start-up Funding for the First Affiliated Hospital of USTC(RC2021012);the Fundamental Research Funds for Central Universities(WK9110000004).
Metabolic dysfunction-associated steatotic liver disease(MASLD),formerly known as non-alcoholic fatty liver disease,has a high global prevalence and can progress to metabolic dysfunction-associated steatohepatitis,cir...
关键词：MASLD Lipid metabolism Cholesterol metabolism LIPOGENESIS LIPOLYSIS lipid metabolism-targeted drugs Chinese proprietary medicine 
The flavonoid glycoside vaccarin inhibits adipogenesis and stimulates lipolysis via Hedgehog signaling in 3T3-L1 adipocytes
《Food and Health》2024年第2期4-13,共10页Cui-Cui Zeng Martin G.Banwell Ping Lan Wei-Min Chen Jing Chen 
This work was graciously supported by the Chinese National Natural Science Foundation(Grant 31901725 and 32201933);the Science and Technology Projects in Guangzhou(Grant 202201010170).
Vaccarin,a flavonoid glycoside isolated from Vaccaria segetalis,is non-toxic to 3T3-L1 cells up to concentrations of 200μM.Accordingly,we investigated the effects of this natural product on adipogenesis and lipolysis...
关键词：ADIPOGENESIS LIPOLYSIS Hedgehog signaling Vaccarin 3T3-L1 adipocytes 
β-Lactoglobulin stabilized lipid nanoparticles enhance oral absorption of insulin by slowing down lipolysis被引量：1
《Chinese Chemical Letters》2024年第4期287-291,共5页Lu Li Suticha Chunta Xianzi Zheng Haisheng He Wei Wu Yi Lu 
funded by the Science and Technology Committee of Shanghai Municipality (Nos.19430741400, 23S11901500,23ZR1413100, and 21430760800);the National Natural Science Foundation of China (Nos.81973247 and 82030107)。
Lipid-based nanocarriers have staged a remarkable comeback in the oral delivery of proteins and peptides, but delivery efficiency is compromised by lipolysis. β-Lactoglobulin(β-lg) stabilized lipid nanoparticles, in...
关键词：Β-LACTOGLOBULIN Lipid nanoparticles Oral absorption INSULIN LIPOLYSIS Aggregation-caused quenching 
The in vitro digestion fates of diacylglycerol under different intestinal conditions:a potential lipid source for lipid indigestion patients
《Food Science and Human Wellness》2024年第2期1079-1092,共14页Qingqing Xu Weifei Wang Dongxiao Sun-Waterhouse Qian Zou Menglei Yan Xuan Liu Dongming Lan Yonghua Wang 
National Key R&D Program of China(2022YFC2805100);National Science Fund for Key Program of National Natural Science Foundation of China(31930084);National Science Fund for Distinguished Young Scholars of China(31725022);China Agriculture Research System(CARS-18-ZJ0503);Guangdong Provincial Key R&D Programme(2022B0202010002);Science and Technology Innovation Project of Foshan City(FS0AAKJ919-4402-0013)。
The in vitro digestion models mimicking the gastrointestinal(GI)tract of general population and lipid indigestion patients(with lower levels of bile salts or pancreatic lipase)were selected to investigate whether diac...
关键词：DIACYLGLYCEROL In vitro digestion Lipolysis level Cholestatic Exocrine pancreatic insufficiency 
Lipolysis supports bone formation by providing osteoblasts with endogenous fatty acid substrates to maintain bioenergetic status被引量：1
《Bone Research》2023年第4期876-894,共19页Ananya Nandy Ron C.M.Helderman Santosh Thapa Shobana Jayapalan Alison Richards Nikita Narayani Michael P.Czech Clifford J.Rosen Elizabeth Rendina-Ruedy 
supported by National Institutes of Health(NIH),the National Institute of Arthritis and Musculoskeletal and Skin Diseases(NIAMS)Grant K01AR072123(ER-R);the American Society of Bone and Mineral Research(ASBMR)Rising Star award;provided by NIH-National Institute of Diabetes and Digestive and Kidney Disease(NIDDK)Grant DK116056(MPC)。
Bone formation is a highly energy-demanding process that can be impacted by metabolic disorders.Glucose has been considered the principal substrate for osteoblasts,although fatty acids are also important for osteoblas...
关键词：ENDOGENOUS MAINTAIN OSTEOBLAST 
Zinc alpha 2 glycoprotein(ZAG):A potential novel pharmacological target in diabetic retinopathy
《BIOCELL》2023年第7期1473-1482,共10页UMAPATHY PRAKASH SUBRAMANIAM RAJESH BHARATHIDEVI RAMYA RNADIG RAJIV R.AMAN GIRISH SHIV RAO MUNA BHENDE 
the Indian Council of Medical Research(ICMR—(5/4/6/1/OPH/2020-NCD-II)).
Zinc alpha 2 glycoprotein(ZAG)is a 41 KDa secretory soluble glycoprotein found in different body fluids like the serum,saliva,sweat,breast milk,and urine.It is also found in tissues like the testis,epididymis,kidney,s...
关键词：ZAG LIPOLYSIS INFLAMMATION Insulin resistance 
Flavor precursors and flavor compounds in Cheddar-flavored enzyme-modified cheese due to pre-enzymolysis combined with lactic acid bacteria fermentation被引量：2
《Food Bioscience》2023年第3期2107-2117,共11页Qin Xiang Yixun Xia Ling Chen Maoshen Chen Di Wang Fang Zhong 
supported by National Natural Science Foundation of China(32001628);Natural Science Foundation of Jiangsu Province(BK20200596,BK20210460);Research project of Zhejiang Lab(2020MC0AD01);supported by national first-class discipline program of Food Science and Technology(JUFSTR20180204);the program of“Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province”,China.
To improve insufficient taste and imbalanced aroma of enzyme-modified cheese(EMC),pre-enzymolysis fol-lowed by lactic acid bacteria(LAB)fermentation was employed in this study.The strategy generated taste compounds by...
关键词：Enzyme-modified cheese(EMC) Proteolysis and lipolysis Flavor precursor Orthogonal partial least squares-discriminant analysis(OPLS-DA) 
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