LIPOGENESIS

作品数：69被引量：233H指数：8
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IRF8 aggravates nonalcoholic fatty liver disease via BMAL1/PPARγ axis
《Genes & Diseases》2025年第3期584-598,共15页Xinyue Li Hong Zhang Fan Yu Shuting Xie Tongyu Wang Rong Zhang Guangzhong Xu Liang Wang Yeping Huang Cheng Hu 
supported by grants from the National Science Foundation of China(No.81974118,82325010);The Shanghai Outstanding Academic Leaders(China)(No.20XD1433300);the Shuguang Project of China(21SG11);the Innovative Research Team of High-level Local Universities in Shanghai,China(No.SHSMU-ZDCX20212700);the Major Natural Science Project of the Scientific Research and Innovation Plan of Shanghai Municipal Commission of Education(China)(No.2023ZKZD17);the Shanghai Research Center for Endocrine and Metabolic Diseases(China)(No.2022ZZ01002);the Shanghai Sixth People’s Hospital Foundation(China)(No.ynqn202105).
Non-alcoholic fatty liver disease(NAFLD)is a hepatic metabolic syndrome arisingfrom lipid metabolic imbalance,with its prevalence increasing globally.In this study,weobserved a significant up-regulation of interferon ...
关键词：Brain and muscle ARNT-Like 1 Hepatic steatosis Interferon regulatory factor 8 LIPOGENESIS Non-alcoholic fatty liver disease Peroxisome proliferator-activated receptorγ Transcriptional regulation 
Reductive stressda common metabolic feature of obesity and cancer
《Acta Pharmaceutica Sinica B》2024年第12期5181-5185,共5页Man Luo Xiwen Ma Jianping Ye 
supported by a project(32271220)from the National Natural Science Foundation of China to Jianping Ye.
Reductive stress,characterized by rising level of NADH(nicotinamide adenine dinucleotide)for a status of NADH/NAD^(+)ratio elevation,has been reported in obesity and cancer.However,the mech-anism and significance of r...
关键词：Reductive stress NADH CANCER OBESITY GLUCONEOGENESIS LIPOGENESIS 
Phytic acid-based nanomedicine against mTOR represses lipogenesis and immune response for metabolic dysfunction-associated steatohepatitis therapy
《Life Metabolism》2024年第6期33-49,共17页Fenghua Xu Shoujie Zhao Yejing Zhu Jun Zhu Lingyang Kong Huichen Li Shouzheng Ma Bo Wang Yongquan Qu Zhimin Tian Junlong Zhao Lei Liu 
supported by the National Natural Science Foundation of China(82373409,82173143,and 82173082);the Top Young Talents Project of“Special Support Program for High Level Talents”in Shaanxi Province(TZ0422,2020−2025);the 2023 program for training talented pilots upon graduation(LHRCYB23009);support from the National Key Research and Development Program of China(2021YFB3500904);the Key Research and Development Program of Shaanxi(2024SF-YBXM-439);the support from the Fundamental Research Funds for the Central Universities(D5000210635 and D5000210829).
Metabolic dysfunction-associated steatohepatitis(MASH)is one of the most common chronic liver diseases and is mainly caused by metabolic disorders and systemic inflammatory responses.Recent studies have indicated that...
关键词：metabolism inhibiting ENDOGENOUS 
Discovery of Alkyl Conjugated Diene Diacids as Novel ACLY Inhibitors
《有机化学》2024年第11期3476-3489,共14页Tingting Cheng Gaolei Song Long Cheng Fan Wang Xinyu Sun Zhifu Xie Mei Zhang Yangming Zhang Jingya Li Fajun Nan 
国家自然科学基金(No.82170872);上海市科委生物医药科技支撑专项(No.20S11903400);上海市科委自然科学基金(No.21ZR1475300)资助项目。
Adenosine triphosphate(ATP)-citrate lyase(ACLY)converts cytosolic citrate from the tricarboxylic acid cycle(TCA cycle)into acetyl coenzyme A(acetyl-CoA),which is a building block for cholesterol and fatty acid synthes...
关键词：metabolic diseases ATP-citrate lyase(ACLY) LIPOGENESIS ACLY inhibitors dienyldicarboxylic acid 
A novel bellidifolin intervention mitigates nonalcoholic fatty liver disease-like changes induced by bisphenol F
《Journal of Biomedical Research》2024年第5期451-463,共13页Jing Xue Linwei Zhang Jingxian Tao Xuexue Xie Xi Wang Linlin Wu Shuhu Du Ninghua Tan Yang Jin Jianming Ju Junting Fan Jun Wang Fei Huan Rong Gao 
supported by the Natural Science Foundation of the Jiangsu Higher Education Institutions of China(Grant No.21KJA330002);Natural Science Foundation of Jiangsu Province(Grant No.BK20211252);Young and Middle-aged Academic Leaders of the"Blue Project"in Jiangsu Universities(2022-2);Jiangsu Health and Family Planning Commission Medical Research Program(Grant No.Z2018035);Project of Public Health Research Center of Jiangnan University(Grant No.JUPH201842);Natural Science Foundation of Nanjing University of Chinese Medicine(Grant No.XZR2020021).
As a potential endocrine-disrupting chemical,bisphenol F(BPF)may cause nonalcoholic fatty liver disease(NAFLD)-like changes,but the mechanisms under its pathogenesis as well as the intervention strategies remain uncle...
关键词：bisphenol F LIPOGENESIS non-alcoholic fatty liver disease bellidifolin 
Mechanism of Metabolic Dysfunction-associated Steatotic Liver Disease:Important role of lipid metabolism
《Journal of Clinical and Translational Hepatology》2024年第9期815-826,共12页Xiaoxi Feng Rutong Zhang Zhenye Yang Kaiguang Zhang Jun Xing 
supported by the Research Start-up Funding for the First Affiliated Hospital of USTC(RC2021012);the Fundamental Research Funds for Central Universities(WK9110000004).
Metabolic dysfunction-associated steatotic liver disease(MASLD),formerly known as non-alcoholic fatty liver disease,has a high global prevalence and can progress to metabolic dysfunction-associated steatohepatitis,cir...
关键词：MASLD Lipid metabolism Cholesterol metabolism LIPOGENESIS LIPOLYSIS lipid metabolism-targeted drugs Chinese proprietary medicine 
Suppressing Wnt signaling of the blood-tumor barrier to intensify drug delivery and inhibit lipogenesis of brain metastases被引量：1
《Acta Pharmaceutica Sinica B》2024年第6期2716-2731,共16页Yang Tong Pei An Puxian Tang Rui Mu Yuteng Zeng Hang Sun Mei Zhao Ziyan Lv Pan Wang Wanjun Han Chunshan Gui Xuechu Zhen Liang Han 
supported by the National Natural Science Foundation of China(32171381 and 81973254);the National Innovation of Science and Technology-2030(Program of Brain Science and Brain-Inspired Intelligence Technology)grant(2021ZD0204004,China);Jiangsu Key Laboratory of Neuropsychiatric Diseases Research Major Program(No.ZZ2101,China);the Priority Academic Program Development of the Jiangsu Higher Education Institutes(PAPD),Suzhou International Joint Laboratory for Diagnosis and Treatment of Brain Diseases,and the Suzhou Science and Technology Development Project(No.SJC2022021,China).
Lipogenesis is often highly upregulated in breast cancer brain metastases to adapt to intracranial low lipid microenvironments.Lipase inhibitors hold therapeutic potential but their intra-tumoral distribution is often...
关键词：LIPOGENESIS Brain metastases Blood-tumor barrier Wnt signaling Drug delivery Fatty acid synthase NANOPARTICLES Combination therapy 
Acetyl coenzyme A carboxylase modulates lipogenesis and sugar homeostasis in Blattella germanica被引量：1
《Insect Science》2024年第2期387-404,共18页Xiaojin Pei Tiantian Bai Yuan Luo Zhanfeng Zhang Sheng Li Yongliang Fan Tong-Xian Liu 
funded by the National Natural Science Foundation of China(32200384);the China Postdoctoral Science Foundation(2022M710053).
Lipid and sugar homeostasis is critical for insect development and survival.In this study,we characterized an acetyl coenzyme A carboxylase gene in Blattella germanica(BgACC)that is involved in both lipogenesis and su...
关键词：acetyl-CoA carboxylase German cockroach lipid biosynthesis sugar tolerance 
Role of Fibrinogen-like Protein 1 in Tumor Recurrence Following Hepatectomy
《Journal of Clinical and Translational Hepatology》2024年第4期406-415,共10页Zahra Shafieizadeh Zohreh Shafieizadeh Maryam Davoudi Reza Afrisham Xiaolei Miao 
supported by the Doctoral Research Fund of Hubei University of Science and Technology,with project number Q201810.
Partial hepatectomy is a first-line treatment for hepatocellular carcinoma.Within 2 weeks following partial hepatectomy,specific molecular pathways are activated to promote liver regeneration.Nevertheless,residual mic...
关键词：Fibrinogen-like protein 1 FGL1 Hepatocellular carcinoma Liver regeneration HEPATECTOMY LIPOGENESIS Recurrence 
Long noncoding RNA lnc_217 regulates hepatic lipid metabolism by modulating lipogenesis and fatty acid oxidation
《The Journal of Biomedical Research》2023年第6期448-459,共12页Xiaoqing Yuan Yawei Liu Xule Yang Yun Huang Xuan Shen Hui Liang Hongwen Zhou Qian Wang Xu Zhang John Zhong Li 
This work was supported by grants from the National Natural Science Foundation of China(Grant Nos.32130050,32201064,and 82170838);the Natural Science Research Project of Universities in Jiangsu Province(Grant No.21KJB180003).
Nonalcoholic fatty liver disease (NAFLD) is considered a major health epidemic with an estimated 32.4% worldwide prevalence. No drugs have yet been approved and therapeutic nodes remain a major unmet need. Long noncod...
关键词：NAFLD lncRNA de novo synthesis β-oxidation 
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