GLUCONEOGENESIS

作品数：53被引量：104H指数：6
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相关机构：华中科技大学浙江中医药大学更多>>
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Sea cucumber derived sulfated sterols alter glucose metabolism by promoting gluconeogenesis and reducing glycogenesis in healthy mice
《Food Science and Human Wellness》2025年第2期719-728,共10页Shanyun Yu Teng Wang Yingcai Zhao Xiaoyue Li Changhu Xue Yuming Wang Tiantian Zhang 
supported by National Natural Science Foundation of China(32072145)。
Sea cucumber derived sulfated sterols significantly ameliorated insulin resistance and decreased lipid accumulation compared to plant sterols.Interestingly,our recent study found that intervention with sea cucumber su...
关键词：Sea cucumber Sulfated sterols Cholesterol sulfate Blood glucose Metabolism 
Reductive stressda common metabolic feature of obesity and cancer
《Acta Pharmaceutica Sinica B》2024年第12期5181-5185,共5页Man Luo Xiwen Ma Jianping Ye 
supported by a project(32271220)from the National Natural Science Foundation of China to Jianping Ye.
Reductive stress,characterized by rising level of NADH(nicotinamide adenine dinucleotide)for a status of NADH/NAD^(+)ratio elevation,has been reported in obesity and cancer.However,the mech-anism and significance of r...
关键词：Reductive stress NADH CANCER OBESITY GLUCONEOGENESIS LIPOGENESIS 
PCK1 attenuates tumor stemness via activating the Hippo signaling pathway in hepatocellular carcinoma
《Genes & Diseases》2024年第4期340-352,共13页Rui Liu Yi Liu Wenlu Zhang Guiji Zhang Zhirong Zhang Luyi Huang Ni Tang Kai Wang 
supported by the National Natural Science Foundation of China(No.82073251,82303854);the Natural Science Foundation Project of Chongqing,China(No.cstc2019jcyj-msxmX0587,cstc2019jscx-dxwtBX0019);the Science and Technology Research Program of Chongqing Municipal Education Commission of China(No.HZ2021006,KJZDM202000401);the Future Medical Youth Innovation Team of Chongqing Medical University(No.W0036,W0101);the Natural Science Foundation of Sichuan Province(No.22NSFSC1284);the Kuanren Talents Program of the Second Affiliated Hospital of Chongqing Medical University.
Liver cancer stem cells were found to rely on glycolysis as the preferred metabolic program.Phosphoenolpyruvate carboxylase 1(PCK1),a gluconeogenic metabolic enzyme,is down-regulated in hepatocellular carcinoma and is...
关键词：Cancer stem cells CHEMORESISTANCE GLUCONEOGENESIS Hepatocellular carcinoma YAP 
Glycolysis and gluconeogenesis are involved of glucose metabolism adaptation during fasting and re-feeding in black carp(Mylopharyngodon piceus)
《Aquaculture and Fisheries》2024年第2期226-233,共8页Yafan Dai Yubang Shen Jiamin Guo Hao Yang Feng Chen Wei Zhang Wenhui Wu Xiaoyan Xu Jiale Li 
supported by China Agriculture Research System of MOF and MARA(CARS-45-03).
Both in nature and in aquaculture,fish may experience periods of food scarcity or hunger.The metabolic regulation of fish when nutritional state changes is a complex process that involves many factors.To study glucose...
关键词：Mylopharyngodon piceus FASTING Glucose metabolism GLYCOLYSIS GLUCONEOGENESIS 
LONP1 ameliorates liver injury and improves gluconeogenesis dysfunction in acute-on-chronic liver failure
《Chinese Medical Journal》2024年第2期190-199,共10页Muchen Wu Jing Wu Kai Liu Minjie Jiang Fang Xie Xuehong Yin Jushan Wu Qinghua Meng 
supported by grants from the Municipal Natural Science Foundation of Beijing,China(No.7192085);the National Natural Science Foundation of China(No.82170643)
Background:Acute-on-chronic liver failure(ACLF)is a severe liver disease with complex pathogenesis.Clinical hypoglycemia is common in patients with ACLF and often predicts a worse prognosis.Accumulating evidence sugge...
关键词：Acute-on-chronic liver failure Lon protease-1 Gluconeogenesis disturbance Mitochondrial dysfunction METABOLISM 
Propionate promotes gluconeogenesis by regulating mechanistic target of rapamycin(mTOR)pathway in calf hepatocytes被引量：1
《Animal Nutrition》2023年第4期88-98,共11页Guo Yan Wang Sen Lin Qin Yi Ning Zheng Hui Jun Geng Lei Chen Jun Hu Yao Lu Deng 
supported by the National Natural Science Foundation of China(grant numbers 32070782,32072761,32100578);the Guangdong Basic and Applied Basic Research Foundation(grant number 2021A1515220036).
Enhancing hepatic gluconeogenesis is one of the main modes of meeting the glucose requirement of dairy cows.This study attempted to determine whether the gluconeogenesis precursor propionate had an effect on the expre...
关键词：PROPIONATE GLUCONEOGENESIS Mechanistic target of rapamycin Palmitic acid 
Gut bacterium promotes host fitness in special ecological niche by affecting sugar metabolism in Drosophila suzukii被引量：1
《Insect Science》2023年第6期1713-1733,共21页Huan-Huan Gao Shan Zhao Rui-Juan Wang Dong-Yun Qin Peng Chen An-Sheng Zhang Qian-Ying Zhuang Yi-Fan Zhai Xian-Hong Zhou 
supported financially through grants from the National Natural Science Foundation of China(31801750,31972273);Science and Technology In-novation Project of Shandong Academy of Agricul-tural Sciences(CXG2023A24,CXG2023A47);National.Natural Science Foundation of Shandong province(ZR2021YQ21,ZR2021QC218).
As an important fruit pest of global significance,Drosophila suzukii occupies a special ecological niche,with the characteristics of high sugar and low protein contents.This niche differs from those occupied by other ...
关键词：carbohydrate metabolism Drosophila suzuki glycolysis/gluconeogenesis Klebsiella oxytoca symbiotic bacteria 
Enhanced glucose homeostasis via Clostridium symbiosummediated glucagon-like peptide 1 inhibition of hepatic gluconeogenesis in mid-intestinal bypass surgery
《World Journal of Gastroenterology》2023年第39期5471-5482,共12页Xin Luo Fang Tao Cai Tan Chi-Ying Xu Zhi-Hua Zheng Qiang Pang Xiang-An He Jia-Qing Cao Jin-Yuan Duan 
National Natural Science Foundation of China,No.82060161,81960154,and 81760156;Jiangxi Provincial Youth Science Foundation,No.2018ACB21040;Natural Science Foundation of Jiangxi Province,No.20212BAB206020;and Foundation of Health commission of Jiangxi Province,No.SKJP220225830.
BACKGROUND The small intestine is known to play a crucial role in the development and remission of diabetes mellitus(DM).However,the exact mechanism by which mid-small intestinal bypass improves glucose metabolism in ...
关键词：Gut micobiome Glucagon-like peptide-1 Glucose metablism Bile acid Bariatric surgery GLUCONEOGENESIS 
Hepatic retinaldehyde deficiency is involved in diabetes deterioration by enhancing PCK1-and G6PC-mediated gluconeogenesis被引量：2
《Acta Pharmaceutica Sinica B》2023年第9期3728-3743,共16页Hanyu Yang Mengxiang Su Ming Liu Yun Sheng Liang Zhu Lu Yang Ruijing Mu Jianjun Zou Xiaodong Liu Li Liu 
supported by the National Natural Science Foundation of China (Nos. 82173884, 82204511, and 82073922);the Jiangsu Funding Program for Excellent Postdoctoral Talent (No. 1412200067, China);the “Double First-Class” university project (No. CPU2022QZ21, China)。
Type 2 diabetes(T2D) is often accompanied with an induction of retinaldehyde dehydrogenase 1(RALDH1 or ALDH1A1) expression and a consequent decrease in hepatic retinaldehyde(Rald)levels. However, the role of hepatic R...
关键词：Type 2 diabetes RETINALDEHYDE Retinaldehyde dehydrogenase 1 GLUCONEOGENESIS Retinoid X receptor Oleic acid GLUCOSE-6-PHOSPHATASE Phosphoenolpyruvate carboxykinase 1 
Liver or kidney:Who has the oar in the gluconeogenesis boat and when?被引量：1
《World Journal of Diabetes》2023年第7期1049-1056,共8页Biswajit Sahoo Medha Srivastava Arpit Katiyar Carolyn Ecelbarger Swasti Tiwari 
Supported by the Indian Council of Medical Research grant to S.T,No.Coord/7(1)/CARE-KD/2018/NCD-II.
Gluconeogenesis is an endogenous process of glucose production from noncarbohydrate carbon substrates.Both the liver and kidneys express the key enzymes necessary for endogenous glucose production and its export into ...
关键词：Gluconeogenesis in the kidney and liver Diabetes Hormonal regulation Metabolic acidosis Insulin resistance Net glucose metabolism 
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