Mechanism of Metabolic Dysfunction-associated Steatotic Liver Disease:Important role of lipid metabolism  

作　　者：Xiaoxi Feng Rutong Zhang Zhenye Yang Kaiguang Zhang Jun Xing 

机构地区：[1]Department of Digestive Disease,The First Affiliated Hospital of USTC,Division of Life Sciences and Medicine,University of Science and Technology of China,Hefei,Anhui,China

出　　处：《Journal of Clinical and Translational Hepatology》2024年第9期815-826,共12页临床与转化肝病杂志（英文版）

基　　金：supported by the Research Start-up Funding for the First Affiliated Hospital of USTC(RC2021012);the Fundamental Research Funds for Central Universities(WK9110000004).

摘　　要：Metabolic dysfunction-associated steatotic liver disease(MASLD),formerly known as non-alcoholic fatty liver disease,has a high global prevalence and can progress to metabolic dysfunction-associated steatohepatitis,cirrhosis,and hepatocellular carcinoma.The pathogenesis of MASLD is primarily driven by disturbances in hepatic lipid metabolism,involving six key processes:increased hepatic fatty acid uptake,enhanced fatty acid synthesis,reduced oxidative degradation of fatty acids,increased cholesterol uptake,elevated cholesterol synthesis,and increased bile acid synthesis.Consequently,maintaining hepatic lipid metabolic homeostasis is essential for effective MASLD management.Numerous novel molecules and Chinese proprietary medicines have demonstrated promising therapeutic potential in treating MASLD,primarily by inhibiting lipid synthesis and promoting lipid oxidation.In this review,we summarized recent research on MASLD,elucidated the molecular mechanisms by which lipid metabolism disorders contribute to MASLD pathogenesis,and discussed various lipid metabolism-targeted therapeutic approaches for MASLD.

关 键 词：MASLD Lipid metabolism Cholesterol metabolism LIPOGENESIS LIPOLYSIS lipid metabolism-targeted drugs Chinese proprietary medicine 

分 类 号：R575[医药卫生—消化系统]