OSTEOBLAST

作品数：192被引量：900H指数：15
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相关领域：医药卫生更多>>
相关作者：刘永强王颖王丽娟王丽娟郭颖洁更多>>
相关机构：广西医科大学中山大学上海交通大学长春中医学院更多>>
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Naked cuticle homolog 2 controls the differentiation of osteoblasts and osteoclasts and ameliorates bone loss in ovariectomized mice
《Genes & Diseases》2025年第1期281-297,共17页Liying Shan Xiaoxia Liao Xiaoli Yang Endong Zhu Hairui Yuan Jie Zhou Xiaoxia Li Baoli Wang 
funded by the National Natural Science Foundation of China(No.82072389,82272444,81972033).
Naked cuticle homolog 2(NKD2)has been recognized as an antagonist of Wnt/β-catenin signaling and a tumor suppressor.The role of NKD2 in osteoblast and osteoclast differentiation and the mechanism are not fully unders...
关键词：Mechanistictargetof rapamycincomplex1 Naked cuticle homolog 2 OSTEOBLAST OSTEOCLAST Receptoractivatorof nuclearfactorkB ligand WNT/Β-CATENIN 
Protein nanoparticles as potent delivery vehicles for polycytosine RNA-binding protein one
《World Journal of Diabetes》2025年第1期222-225,共4页Zi-Yu Zhao Pei-Li Luo Xia Guo Zheng-Wei Huang 
Ma et al recently reported in the World Journal of Diabetes that ferroptosis occurs in osteoblasts under high glucose conditions,reflecting diabetes pathology.This condition could be protected by the upregulation of t...
关键词：Polycytosine RNA-binding protein 1 Protein nanoparticle OSTEOBLAST Ferroptosis DIABETES 
Low-molecular-weight estrogenic phytoprotein suppresses osteoporosis development through positive modulation of skeletal estrogen receptors
《Bioactive Materials》2024年第12期299-315,共17页John Akrofi Kubi Augustine Suurinobah Brah Kenneth Man Chee Cheung Andy Chun Hang Chen Yin Lau Lee Kai-Fai Lee Wei Qiao Yibin Feng Kelvin Wai Kwok Yeung 
supported by the Seed Fund for Translational and Applied Research from the University Research Committee(URC),The University of Hong Kong(HKU),Hong Kong China(Project Codes:201910160024 and 202010160009).
Age-related osteoporosis is a metabolic skeletal disorder caused by estrogen deficiency in postmenopausal women.Prolonged use of anti-osteoporotic drugs such as bisphosphonates and FDA-approved anti-resorptive selecti...
关键词：Ovariectomy(ovx) OSTEOPOROSIS Osteoblast functions Estrogen receptors(ERs) HKUOT-S2 protein 
Osteopetrosis-like disorders induced by osteoblast-specific retinoic acid signaling inhibition in mice
《Bone Research》2024年第4期832-845,共14页Siyuan Sun Yuanqi Liu Jiping Sun Bingxin Zan Yiwen Cui Anting Jin Hongyuan Xu Xiangru Huang Yanfei Zhu Yiling Yang Xin Gao Tingwei Lu Xinyu Wang Jingyi Liu Li Mei Lei Shen Qinggang Dai Lingyong Jiang 
supported in part by grants from the Hainan Provincial Natural Science Foundation of China (824MS152);the National Natural Science Foundation of China (81870740,82071083,82271006,82101048);the National Science Foundation of Shanghai (21ZR1436900,22ZR1436700);the Program of Shanghai Academic/Technology Research Leader (20XD1422300);the Cross-Disciplinary Research Fund of Shanghai Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine (JYJC202116,JYJC201902);the Project of Biobank of Shanghai Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine (YBKB201909,YBKB202216);the Original Exploration Project of Shanghai Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine (JYYC003);the Clinical Research Plan of SHDC (SHDC2020CR4084);the Biomaterials and Regenerative Medicine Institute Cooperative Research Project Shanghai Jiao Tong University School of Medicine (2022LHB02);Two-Hundred Talent Project of Shanghai Jiao Tong University School of Medicine (20221809);Shanghai Jiao Tong University’s“Jiaotong University Star”Program Medical and Industrial Cross Research Fund (YG2023ZD14);Shanghai Science and Technology Innovation Action Plan-International Science and Technology Cooperation Program (23410713600)。
Osteopetrosis is an inherited metabolic disease,characterized by increased bone density and narrow marrow cavity.Patients with severe osteopetrosis exhibit abnormal bone brittleness,anemia,and infection complications,...
关键词：IMPAIRED METABOLISM SPLEEN 
DNMT aberration-incurred GPX4 suppression prompts osteoblast ferroptosis and osteoporosis
《Bone Research》2024年第4期966-979,共14页Binjia Ruan Jian Dong Fanhao Wei Zhiqiang Huang Bin Yang Lijun Zhang Chuling Li Hui Dong Wangsen Cao Hongwei Wang Yongxiang Wang 
supported by the National Key Research and Development Program of China (2023YFB3810200,2023YFB3810204,2022YFF0710801);the National Natural Science Foundation of China (82470749,82370899,82272502,82072423)。
Osteoporosis(OP)is a common and fracture-prone skeletal disease characterized by deteriorated trabecular microstructure and pathologically involving various forms of regulated bone cell death.However,the exact role,ce...
关键词：reversed PRESERVING exact 
Induction of osteoblast apoptosis stimulates macrophage efferocytosis and paradoxical bone formation
《Bone Research》2024年第3期634-647,共14页Lena Batoon Amy Jean Koh Susan Marie Millard Jobanpreet Grewal Fang Ming Choo Rahasudha Kannan Aysia Kinnaird Megan Avey Tatyana Teslya Allison Robyn Pettit Laurie K.McCauley Hernan Roca 
supported in part by funding from the National Institutes of Health (DK053904,DE022327,AR077539,CA093900,CA046592 and P30 AR069620);National Health and Medical Research Council (APP1143802);Mater Foundation.
Apoptosis is crucial for tissue homeostasis and organ development.In bone,apoptosis is recognized to be a main fate of osteoblasts,yet the relevance of this process remains underexplored.Using our murine model with in...
关键词：development HOMEOSTASIS BONE 
Anti-osteoporosis properties of phosphorylated collagen peptidemagnesium chelates in osteoblast MC3T3-E1 cells and ovariectomized mice
《Chinese Medical Journal》2024年第14期1762-1764,共3页Chao Zhang Bowei Du Guiya Deng Shuai Zhang Tengfei Yu Yuepeng Guan Yaqin Huang 
supported by grants from the Fundamental Research Funds for the Central Universities(No.JD2231);the National Natural Science Foundation of China(No.82102038).
To the Editor:Postmenopausal osteoporosis is a typical bone metabolic disruption disease caused by estrogen deficiency,characterized by deteriorated bone structure,reduced bone mineral density(BMD),and thinned sclerot...
关键词：OSTEOPOROSIS INFLAMMATION MAGNESIUM 
Macrophage exosomes modified by miR-365-2-5p promoted osteoblast osteogenic differentiation by targeting OLFML1
《Regenerative Biomaterials》2024年第3期134-147,共14页Caiyao Hou Yujue Zhang Zhaoyong Lv Yurun Luan Jun Li Chunxiu Meng Kun Liu Xin Luo Liyu Chen Fengzhen Liu 
the Science Foundation of Shandong Province of China(Grant Nos ZR2021MH026,ZR2022MH075,ZR2020MH100);Shandong Province Medical and Health Science and Technology Development Plan(2018WS426);Liaocheng Key Research and Development Plan of Shandong Province of China(Grant Nos 2022YDSF16,2022YDSF21,2023YD28,2023YD34).
In the bone immune microenvironment,immune cells can regulate osteoblasts through a complex communication network.Macrophages play a central role in mediating immune osteogenesis,exosomes derived from them have osteog...
关键词：MACROPHAGE EXOSOMES OSTEOGENESIS OSTEOIMMUNOLOGY 
The roles of extracellular vesicles released by mechanically stimulated osteocytes in regulating osteoblast and osteoclast functions
《Mechanobiology in Medicine》2024年第2期71-78,共8页Yumei Chen Runze Zhao Li Yang X.Edward Guo 
Bone adapts to mechanical loading by changing its shape and mass.Osteocytes,as major mechanosensors,are critical for bone modeling/remodeling in response to mechanical stimuli.Intracellular calcium oscillation is one ...
关键词：OCY454 OSTEOCYTE MECHANOTRANSDUCTION Fluid flow Extracellular vesicles 
The water-soluble TF3 component from Eupolyphaga sinensis Walker promotes tibial fracture healing in rats by promoting osteoblast proliferation and angiogenesis
《Journal of Traditional Chinese Medical Sciences》2024年第2期245-254,共10页Binghao Shao Xing Chen Jin'ge Du Shuang Zou Zhaolong Chen Jing Wang Huaying Jiang Ruifang Lu Wenlan Wang Chunmei Wang 
supported by“the Fundamental Research Funds for the Central Universities”(2020-JYB-ZDGG-054);“Beijing university of Chinese medicine XINAO Award Fund”(2019);Beijing University of Chinese Medicine Scientific Research and Development Fund(2170072220002).
Objective:To determine the active components of Eupolyphaga sinensis Walker(Tu Bie Chong)and explore the mechanisms underlying its fracture-healing ability.Methods: A modified Einhorn method was used to develop a rat ...
关键词：Tu Bie Chong Water-solube component Fracture RATS OSTEOBLAST ANGIOGENESIS 
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