OSTEOGENESIS

作品数：365被引量：1206H指数：15
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相关机构：上海交通大学附属第六人民医院浙江大学医学院附属第一医院武汉大学上海交通大学更多>>
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Actin polymerization regulates the osteogenesis of hAsCs by influencingα-tubulin expression and Eg5 activity
《Genes & Diseases》2025年第2期29-32,共4页Tingyu Fan Wenqing Liu Rongmei Qu Jinhui Zhu Yulian Shi Jiaxuan Liu Xiangtian Li Zhitao Zhou Yunbing Chang Jun Ouyang Jingxing Daia 
supported by the National Key R&D Program of China (No.2022YFF1202603);the President's Foundation of TCM-Integrated Hospital of Southern Medical University (No.1202103001).
Seed cells,scaffold materials,and growth factors constitute the three fundamental components of bone tissue engineering.In recent years,human adipose-derived stem cells(hASCs)have emerged as promising candidate cells ...
关键词：Eg5 engineering. CONSTITUTE 
Oxidative stress-induced circSOD2 inhibits osteogenesis through sponging miR-29b in metabolic-associated fatty liver disease
《World Journal of Gastroenterology》2025年第9期68-82,共15页Liang-Ping Li Xiao-Ying Chen Hong-Bo Liu Yi Zhu Min-Jie Xie Yong-Jian Li Meng Luo Mugahed Albahde Hong-Yu Zhang Jian-Ying Lou 
Supported by the National and Zhejiang Provincial Administration of Traditional Chinese Medicine Co-construction Project,No.GZYZJ-KJ-24080;the Medical Science and Technology Project of Zhejiang Province,No.2024XY228.
BACKGROUND Metabolic-associated fatty liver disease(MAFLD)is characterized by lipid accumulation in hepatocytes and is closely associated with oxidative stress.Increasing clinical evidence indicates that MAFLD is link...
关键词：Circular RNAs MICRORNAS Oxidative stress OSTEOGENESIS Non-alcoholic fatty liver disease OSTEOPOROSIS 
Roles of lncRNA in the crosstalk between osteogenesis and angiogenesis in the bone microenvironment
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2025年第2期107-123,共17页Shihua ZHANG Jianmin GUO Yuting HE Zhi’ang SU Yao FENG Lan ZHANG Jun ZOU Xiquan WENG Yu YUAN 
supported by the National Natural Science Foundation of China(No.81901430);the Guangdong Basic and Applied Basic Research Foundation(No.2022A1515010379);the Science and Technology Projects in Guangzhou(No.2023A04J0555);the Guangdong Provincial Key Laboratory of Physical Activity and Health Promotion(No.2021B1212040014),China.
Bone is a highly calcified and vascularized tissue.The vascular system plays a vital role in supporting bone growth and repair,such as the provision of nutrients,growth factors,and metabolic waste transfer.Moreover,th...
关键词：Long noncoding RNA(lncRNA) OSTEOGENESIS Bone angiogenesis OSTEOPOROSIS Bone microenvironment 
A facile nanopattern modification of silk fibroin electrospun scaffold and the corresponding impact on cell proliferation and osteogenesis
《Regenerative Biomaterials》2025年第1期142-155,共14页Xiaojiao Liu Qinjun Ouyang Xiang Yao Yaopeng Zhang 
supported by the International Cooperation Fund of the Science and Technology Commission of Shanghai Municipality(22520711900);National Natural Science Foundation of China(52273125,52173031);the Fundamental Research Funds for the Central Universities(2232024D-01);the Basic Research Project of the Science and Technology Commission of Shanghai Municipality(21JC1400100);the Oriental Talent Plan(Leading Talent Program,no.152).
As a well-known natural protein biomaterial,silk fibroin(SF)has shown broad application prospects in typical biomedical fields.However,the mostly used SF from Bombyx mori silkworm lacks specific cell adhesion sites an...
关键词：silk fibroin nanopattern modification electrospinning cell-material interaction plasma etching 
Magnesium and gallium-coloaded microspheres accelerate bone repair via osteogenesis and antibiosis
《Bio-Design and Manufacturing》2025年第1期150-165,I0056-I0059,共20页Jin Bai Si Shen Yan Liu Shendan Xu Tianqi Li Zirou Wang Weili Liu Lingling Pu Gang Chen Xinxing Wang 
supported by grants from the National Natural Science Foundation of China(Nos.31971106,BWS21L013,and 21WS09002).
Bone defects have serious economic and clinical impacts;however,despite improvements in bone defect management,the range of clinical outcomes remains limited.A variety of biomaterials have been used to treat complex b...
关键词：MICROSPHERE OSTEOGENESIS ANTIBACTERIA MAGNESIUM GALLIUM 
Biodegradable Mg-Ca/Mg-Cu bilayer membranes with enhanced mechanical,osteogenesis and antibacterial performances for GBR applications
《Journal of Magnesium and Alloys》2025年第2期792-809,共18页Yanbo Shan Bo Qiao Sihui Ouyang Chengao Du Lisheng Zhao Gang Wang Jianting Ye Yingjie Xiong Yu Wei Jiangfeng Song Jia She Jiang Peng Xianhua Chen Fusheng Pan Ning Wen 
supported by the National Natural Science Foundation of China(51972339,52072023,and 51802350);the National Natural Science Found for Distinguished Young Scholars(52225101);the China Postdoctoral Science Foundation(2022M720551);the Natural Science Foundation of Chongqing(CSTB2023NSCQ-MSX0527,cstc2021jcyj-msxmX0993);the Chongqing Academician Special Fund(2022YSZX-JCX0014CSTB);the Chongqing Science and Technology Commission(CSTB2022NSCQ-MSX0416).
Magnesium(Mg)alloys with biodegradability and excellent mechanical properties are in high demand for applications in guided bone regeneration(GBR).However,the clinical application of Mg alloys is hindered by infection...
关键词：BIODEGRADABILITY Magnesium alloy Guided bone regeneration membrane OSTEOGENESIS ANTIBACTERIAL 
Self-assembled biodegradable herbal-based nanoflower decorative magnesium implants combine therapy with bone regeneration
《Journal of Magnesium and Alloys》2025年第1期130-147,共18页Huihui Du Dongdong Zhang Kui Xue Limin Ma Ru Xu Ji Tan Feng Peng Xuanyong Liu 
supported by the National Key R&D Program of China(2021YFC2400500);Shanghai Committee of Science and Technology,China(20S31901200);the Fundamental Research Funds for the Central Universities(2022ZYGXZR042);Postdoctoral Science Foundation of China(2022M723288);GDPH Supporting Fund for Talent Program(KY0120220137).
The rapid corrosion rate and limited biological functionality still pose challenges for magnesium(Mg)-based implants in the treatment of complicated bone-related diseases in clinic.Herein,a multifunctional biodegradab...
关键词：Magnesium-based implants Herbal medicine Curcumin-ferrum nanoflower Anti-bacterial/tumor OSTEOGENESIS 
Novel injectable composite incorporating denosumab promotes bone regeneration via bone homeostasis regulation
《Engineered Regeneration》2024年第4期482-494,共13页Guang Yang Zili Guo Xiangfeng Zhang Jiayu Chen Jie Weng Jiapeng Bao Xiaohua Yu 
supported by the National Natural Science Foundation of China(Grant No.82372381,52071277);the National Natural Science Foundation of Zhejiang Province(Grant No.LY23H060013).
Repair of large bone defects remains to be clinically challenging,yet current bone repair strategies focus on optimizing the osteogenic capacity of bone grafts,while the role of osteoclasts in bone regeneration has be...
关键词：Bone regeneration DENOSUMAB OSTEOCLASTOGENESIS OSTEOGENESIS 
ECM-mimicking composite hydrogel for accelerated vascularized bone regeneration
《Bioactive Materials》2024年第12期241-256,共16页Guanglong Li Fei Gao Donglei Yang Lu Lin Weijun Yu Jiaqi Tang Ruhan Yang Min Jin Yuting Gu Pengfei Wang Eryi Lu 
supported by National Natural Science Foundation of China(Grant Nos.52171075,52103172,82271589);Science and Technology Commission of Shanghai Municipality(Grant Nos.21DZ2294700,21ZR1439400);Opening Project of Shanghai Key Laboratory of Orthopaedic Implant(Grant No.KFKT2021001);the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences(Grant No.2023-JKCS-14);Incubating Program for National Program of Renji Hospital,Shanghai Jiao Tong University School of Medicine(Grant No.RJTJ23-PY-053);“Clinic Plus”Outstanding Project of Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine(Grant No.2021ZYA009).
Bioactive hydrogel materials have great potential for applications in bone tissue engineering.However,fabrication of functional hydrogels that mimic the natural bone extracellular matrix(ECM)remains a challenge,becaus...
关键词：Composite hydrogel DNA hydrogel Stress relaxation OSTEOGENESIS VASCULARIZATION 
Remodeling Electrophysiological Microenvironment for Promoting Bone Defect Repair via Electret Hybrid Electrospun Fibrous Mat
《Advanced Fiber Materials》2024年第6期1855-1873,共19页Jinjie Cui Bin Yu Dejian Li Zeyu Fu Xiuyi Yang Lingyong Jiang Xudong Wang Kaili Lin 
supported by the National Natural Science Foundation of China(32271379,82072396,52203309);Science and Technology Commission of Shanghai Municipality(23YF1421500,22YF1400400,21490711700);Cross Disciplinary Research Fund of Shanghai Ninth People's Hospital,Shanghai Jiao Tong University School of Medicine(JYJC202219);Shanghai's Top Priority Research Center(2022ZZ01017);CAMS Innovation Fund for Medical Sciences(CIFMS,2019-I2M-5-037);Fund of Department of Oral and Maxillofacial Surgery(Department 2022-04);the Fundamental Research Funds for the Central Universities(2232022D-09).
Improving the osteogenic properties of bone grafts plays a critical role in the repair and functional restoration of critical-sized bone defects.The endogenous electric field,one of the most crucial physiological sign...
关键词：ELECTRET Electrophysiological microenvironment OSTEOGENESIS Electrospun fibrous mat 
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