Magnesium and gallium-coloaded microspheres accelerate bone repair via osteogenesis and antibiosis  

镁和镓共载微球通过成骨和抗菌加速骨修复

作　　者：Jin Bai Si Shen Yan Liu Shendan Xu Tianqi Li Zirou Wang Weili Liu Lingling Pu Gang Chen Xinxing Wang 白瑾;沈思;刘颜;徐沈丹;李天琪;王紫糅;刘伟丽;蒲玲玲;陈刚;王新兴(天津环境医学与作业医学研究所(军事科学院军事医学研究院),天津市300050;天津医科大学口腔医学院,天津市300070)

机构地区：[1]Tianjin Institute of Environmental and Operational Medicine,Tianjin 300050,China [2]School and Hospital of Stomatology,Tianjin Medical University,Tianjin 300070,China

出　　处：《Bio-Design and Manufacturing》2025年第1期150-165,I0056-I0059,共20页生物设计与制造(英文)

基　　金：supported by grants from the National Natural Science Foundation of China(Nos.31971106,BWS21L013,and 21WS09002).

摘　　要：Bone defects have serious economic and clinical impacts;however,despite improvements in bone defect management,the range of clinical outcomes remains limited.A variety of biomaterials have been used to treat complex bone defects.However,final bone repair outcomes may be adversely affected by poor osteogenic capacity and risk of infection.Consequently,therapeutic methods are required that reduce bacterial contamination and increase the use of osteogenic biomaterials.Herein,we report the preparation of poly(lactic acid-coglycolic acid)(PLGA)microspheres coloaded with magnesium(Mg^(2+))and gallium(Ga^(3+))ions(Mg-Ga@PLGA),which can fill irregular bone defects and show good biosafety.During in vitro testing,Mg-Ga@PLGA not only showed a synergistic effect on promoting osteogenic differentiation but also inhibited osteoclastic differentiation.Moreover,we found that Mg-Ga@PLGA demonstrated an antibacterial effect.During in vivo testing,Mg Ga@PLGA exhibited strong in situ osteogenic ability.In conclusion,Mg-Ga@PLGA has good potential for treating bone defects at risk of infection.骨缺损对经济和临床都有严重影响;尽管骨缺损治疗方法有所改善,但临床所实现的效果仍然有限。各种生物材料已被用于治疗复杂的骨缺损。然而,最终的骨修复效果可能会受到成骨能力和感染风险的不利影响。因此,我们需要能减少细菌污染并提高成骨生物材料使用率的治疗方法。在此,我们提出聚乳酸-乙二酸(PLGA)微球与镁(Mg^(2+))和镓(Ga^(3+))离子(Mg-Ga@PLGA)共载的制备方法,它可以填充不规则的骨缺损,并具有良好的生物安全性。在体外测试中,Mg-Ga@PLGA在促进成骨分化和抑制破骨分化方面表现出协同作用。此外,我们还发现Mg-Ga@PLGA具有抗菌作用。在体内,Mg-Ga@PLGA表现出很强的原位成骨能力。总之,Mg-Ga@PLGA在治疗有感染风险的骨缺损方面具有良好的潜力。

关 键 词：MICROSPHERE OSTEOGENESIS ANTIBACTERIA MAGNESIUM GALLIUM 

分 类 号：R32[医药卫生—人体解剖和组织胚胎学]