supported by a grant from the French Society of Sleep Research and Medicine(to LS);The China Scholarship Council(to HL);The CNRS,INSERM,Claude Bernard University Lyon1(to LS)。
The sleep-wake cycle stands as an integrative process essential for sustaining optimal brain function and,either directly or indirectly,overall body health,encompassing metabolic and cardiovascular well-being.Given th...
supported by the National Key R&D Program of China(2022YFD1700200);the Natural Science Foundation of Shanxi Province,China(20210302123440);the Fund for Shanxi“1331 Project”and the Graduate Education Innovation Project of Shanxi Province,China(2023SJ033).
Syntaxin 1A(Syx1A)has diverse and indispensable functions in animals.Pre-vious studies have mainly focused on the roles of Syx1A in Drosophila,and so how Syx1A operates during the development of other insects remains ...
Diabetes mellitus and hypertension are two of the most prevalent diseases affecting individuals across all age groups. Both conditions are linked to an increased risk of heart disease, peripheral vascular disease, str...
BACKGROUND Not all islet transplants desirably achieve insulin independence.This can be attributed to the microarchitecture and function of the islets influenced by their dimensions.Large islets enhance insulin secret...
BACKGROUND Thyrotoxic periodic paralysis(TPP)is an endocrine emergency caused by thyrotoxicosis,manifesting mainly as periodic myasthenia and hypokalemia,and posing a serious threat to the patient's health.Fatigue,str...
BACKGROUND Acute hyperglycemia due to insulin resistance is common in critically ill patients,typically managed with insulin infusion.However,the occurrence of transient extreme insulin resistance(EIR)requiring except...
financially supported by the National Natural Science Foundation of China(Nos.52273009 and 21674037).
Insulin is an essential and versatile protein taking part in the control of blood glucose levels and protein anabolism.However,under prolonged storage or high temperature stress,insulin tends to unfold and aggregate i...
Supported by CAMS Innovation Fund for Medical Sciences,No.2023-I2M-C&T-B-043;National High Level Hospital Clinical Research Funding,No.2022-PUMCH-B-015;CAMS Innovation Fund for Medical Sciences,No.2021-1-12M-002;Beijing Municipal Natural Science Foundation,No.M22014.
BACKGROUND There is a lack of clinical evidence on the efficacy and safety of transitioning from a thrice-daily pre-mixed insulin or basal-prandial regimen to insulin degludec/aspart(IDegAsp)therapy,with insufficient ...
The recent study exploring the bidirectional associations between gallstone disease,non-alcoholic fatty liver disease,and kidney stone disease highlights a critical concern in chronic disease management.Given the risi...
Athletes often use branched-chain amino acid (BCAAs) supplements with a ratio of 2:1:1 (leucine:isoleucine:valine) for their impact on muscle building. Research suggests that by altering the ratio, an improvement in g...