BACKGROUND Not all islet transplants desirably achieve insulin independence.This can be attributed to the microarchitecture and function of the islets influenced by their dimensions.Large islets enhance insulin secret...
funded by national funds;through the Foundation for Science and Technology (FCT)-project UIDB/50026/2020 and UIDP/50026/2020;by the National Ataxia Foundation (NAF)
Spinocerebellar ataxias are heritable neurodegenerative diseases caused by a cytosine-adenine-guanine expansion,which encodes a long glutamine tract(polyglutamine)in the respective wild-type protein causing misfolding...
Supported by CNPq,No.308901/2020,No.400856/2016-6;FAPESP,No.2019/21070-3,No.2017/17868-4,No.2016/21470-3;SisNANO 2.0/MCTIC,No.442539/2019-3;the National Institute of Science and Technology Complex Fluids(INCT-FCx);“Amigos da Oncologia e Hematologia Einstein”AMIGOH.
BACKGROUND Bone marrow transplantation(BMT)can be applied to both hematopoietic and nonhematopoietic diseases;nonetheless,it still comes with a number of challenges and limitations that contribute to treatment failure...
This work was supported by grants from the NSFC(81941008,81870091 and 81900174);the Chinese Ministry of Education(IRT_15R24);The Strategic Priority Research Program of the Chinese Academy of Sciences(XDA16030303);the Chinese MOST(2017YFA0104402).
Allogeneic hematopoietic cell transplantation(allo-HCT)is a promising therapeutic option for hematological malignancies,but relapse resulting predominantly from residual disease in the bone marrow(BM)remains the major...
Understanding the nature of cell surface markers on exfoliated colonic cells is a crucial step in establishing criteria for a normally functioning mucosa. We have found that colonic cells isolated from stool samples (...
Supported by a pilot grant from the Indiana University Center of Excellence in Molecular Hematology,NIDDK,No.P30DK090948(to Hege KM and Goebel WS);the NIH/NCI Cancer Center,No.P30CA082709 awarded to the Indiana University Simon Comprehensive Cancer Center(to Sinn A and Pollok KE)。
BACKGROUND Peripheral blood stem cells(PBSC)are commonly cryopreserved awaiting clinical use for hematopoietic stem cell transplant.Long term cryopreservation is commonly defined as five years or longer,and limited da...
Mesenchymal stem cells(MSCs)are promising candidates for bone regeneration therapies due to their plasticity and easiness of sourcing.MSC-based treatments are generally considered a safe procedure,however,the long-ter...
Primary immunodeficiency disorders (PIDs) result from inborn errors in immunity.Susceptibility to infections and oftentimes severe autoimmunity pose life-threatening risks to patients with these disorders.Hematopoieti...
AIM To investigate infused hematopoietic cell doses and their interaction with conditioning regimen intensity +/-total body irradiation(TBI) on outcomes after peripheral blood hematopoietic cell transplant(PBHCT).METH...
Supported by the National Natural Science Foundation of China(Nos.81471201 and 81171089)
Mesenchymal stromal/stem cells(MSCs) are multipotent cells under consideration as a potential new therapy for a variety of inflammatory diseases including certain neurological disorders. It is generally thought that t...