SECRETOME

作品数：86被引量：149H指数：7
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相关机构：东北农业大学复旦大学上海交通大学医学院附属瑞金医院清华大学更多>>
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Secretome of polarized macrophages:potential for targeting inflammatory dynamics in spinal cord injury
《Neural Regeneration Research》2025年第11期3231-3232,共2页Andreia Monteiro Susana Monteiro Nuno A.Silva 
funded by national funds,through the Foundation for Science and Technology(FCT)-project UIDB/50026/2020,UIDP/50026/2020(to NAS),EXPL/MEDPAT/0931/2021(to SM);Financial support was provided by Prémios Santa Casa Neurociências-Prize Melo e Castro for Spinal Cord Injury Research(MC-18-2021);Wings For Life Spinal Cord Research Foundation(WFL-PT-14/23);"la Caixa"Foundation(HR23-00484)(to NAS);the FCT for the Scientific Employment Stimulus to NAS and SM(CEECIND/04794/2017 and CEECIND/01902/2017)。
Spinal cord injury(SCI)involves an initial traumatic phase,followed by secondary events such as ischemia,increased blood-spinal cord barrier permeability,ionic disruption,glutamate excitotoxicity,and metabolic alterat...
关键词：alterations injury COMPANIES 
Does mesenchymal stem cell’s secretome affect spinal sensory circuits?Implication for pain therapies
《Neural Regeneration Research》2025年第1期181-183,共3页Francesco Ferrini Esri H.Juárez Adalberto Merighi 
supported by the National Centre for the Replacement Refinement & Reduction of Animals in Research Crack It solution “Neuroinflammation and nociception in a dish”(https://nc3rs.org.uk/crackit/news/new-solutionneuroinflammation-and-nociception-dish) fund(to AM)。
Mesenchymal stem cells(MSCs)are multipotent adult stem cells of mesodermal origin that can be isolated from various tissues,including bone marrow,tooth pulp,adipose tissue,and umbilical cord.MSCs have gained significa...
关键词：protective clinical COLLECTIVE 
Stem cell secretome restore the adipo-osteo differentiation imbalance in diabetic dental pulp-derived mesenchymal stem cells
《Chronic Diseases and Translational Medicine》2024年第4期340-349,共10页Avinash Sanap Kalpana Joshi Supriya Kheur Ramesh Bhonde 
Council of Scientific and Industrial Research(CSIR),Government of India。
Background:Mesenchymal stem cells(MSCs)from type 2 diabetes mellitus(T2DM)individuals exhibit increased adipogenesis and decreased osteogenesis.We investigated the potential of adipose tissue-derived MSCs(ADMSCs)secre...
关键词：DIFFERENTIATION mesenchymal stem cells MICROENVIRONMENT SECRETOME type 2 diabetes mellitus 
Augmenting osteoporotic bone regeneration through a hydrogel-based rejuvenating microenvironment
《Bioactive Materials》2024年第11期440-454,共15页Xiaoting Zhang Boguang Yang Lu Feng Xiayi Xu Chenmin Wang Yuk-wai Lee Ming Wang Xuan Lu Ling Qin Sien Lin Liming Bian Gang Li 
National Natural Science Foundation of China(82172430 and 82272505);University Grants Committee,Research Grants Council of the Hong Kong Special Administrative Region,China(14113723,14108720,14121721,14202920,N_CUHK472/22,C7030-18G,T13-402/17-N and AoE/M-402/20);Heath and Medical Research Fund(HMRF)Hong Kong(17180831,08190416 and 09203436);Hong Kong Innovation Technology Commission Funds(PRP/050/19FX),CUHK direct grant(2022.042).
Osteoporotic bone defects pose a significant challenge for bone regeneration as they exhibit impaired healing capacity and delayed healing period.To address this issue,this study introduces a hydrogel that creates a r...
关键词：Osteoporotic bone defects Bone regeneration Rejuvenating microenvironment SECRETOME Focal adhesion pathway 
Mesenchymal stem cell-derived extracellular vesicles in skin wound healing: the risk of senescent drift induction in secretome-based therapeutics
《Military Medical Research》2024年第5期792-793,共2页Anna Smirnova Elena Yatsenko Denis Baranovskii Ilya Klabukov 
Regulatory changes in senescent cells could potentially affect the composition of extracellular vehicles(EVs),specifically altering their size and cargo.As a result,the released senescent EVs contain an unpredictable ...
关键词：Cell therapy INFLAMMAGING SECRETOME SENESCENCE 
Emergence of the stromal vascular fraction and secretome in regenerative medicine
《World Journal of Stem Cells》2024年第10期896-899,共4页Ratan Kumar Choudhary Shanti Choudhary Abhishek Tripathi 
Supported by the Department of Biotechnology,Ministry of Science and Technology,Government of India,New Delhi,No.BT/PR42179/AAQ/1/814/2021;SERB-State University Research Excellence,No.SUR/2022/001952.
Recently,we read a mini-review published by Jeyaraman et al.The article explored the optimal methods for isolating mesenchymal stromal cells from adipose tissue-derived stromal vascular fraction(SVF).Key factors inclu...
关键词：Stromal vascular fraction Mesenchymal stem cells Veterinary regenerative medicine Isolation procedures Canine model SECRETOME 
Mesenchymal stem cell secretome: A promising therapeutic strategy for erectile dysfunction?
《Asian Journal of Urology》2024年第3期391-405,共15页Ria Margiana Younes Pilehvar Fatkhurrohmah LAmalia Silvia WLestari Supardi Supardi Reny I’tishom 
Objective:The secretome,comprising bioactive chemicals released by mesenchymal stem cells(MSCs),holds therapeutic promise in regenerative medicine.This review aimed to explore the therapeutic potential of the MSC secr...
关键词：Erectile dysfunction Mesenchymal stem cell Mesenchymal stem cell secretome Mesenchymal stem cell-derived exosome 
Mesenchymal stem cells’“garbage bags”at work:Treating radial nerve injury with mesenchymal stem cell-derived exosomes被引量：1
《World Journal of Stem Cells》2024年第5期467-478,共12页Mazhar Mushtaq Doaa Hussein Zineldeen Muhammad Abdul Mateen Khawaja Husnain Haider 
Unlike central nervous system injuries,peripheral nerve injuries(PNIs)are often characterized by more or less successful axonal regeneration.However,structural and functional recovery is a senile process involving mul...
关键词：EXOSOME Mesenchymal stem cells Nerve injury Stem cells SECRETOME Regeneration 
Mesenchymal Stem Cell-Derived Secretome-Based Therapy for Neurological Disorders: A Scoping Review
《Stem Cell Discovery》2024年第1期1-19,共19页Charbel Khalil Alain Chebly Frederic Harb Fabienne Abi Antoun Khalil Akouche Rita Khalil Albert Azar Maria Khalil Bahij Chaar Samar Abbas Colette Hanna Ahmad Ibrahim 
Stem cells are the foundation of cellular therapy. They are multipotent cells capable of self-renewing and differentiating into several cell lineages. They are being investigated and used for the treatment of a wide r...
关键词：Neurological Disorders Mesenchymal Stem Cells EXOSOMES Extracellular Vesicles Stem Cell Therapy 
Etanercept-synthesizing adipose-derived stem cell secretome:A promising therapeutic option for inflammatory bowel disease
《World Journal of Gastrointestinal Surgery》2024年第3期882-892,共11页Say-June Kim Ok-Hee Kim Ha-Eun Hong Ji Hyeon Ju Do Sang Lee 
Supported by the National Research Foundation of Korea(NRF)grant funded by the Korea government(MSIT),No.NRF-2021R1F1A1064566.
BACKGROUND Inflammatory bowel disease(IBD)is a chronic inflammatory condition of the gastrointestinal tract,with tumor necrosis factor(TNF)-αplaying a key role in its pathogenesis.Etanercept,a decoy receptor for TNF,...
关键词：Adipose-derived stem cells ETANERCEPT Inflammatory bowel disease SECRETOME Tumor necrosis factor-α 
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