DIFFERENTIATION

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Mesenchymal stem cell-derived small extracellular vesicles enhance the therapeutic effect of retinal progenitor cells in retinal degenerative disease rats
《Neural Regeneration Research》2026年第2期821-832,共12页Chunge Ren Min Chen Bangqi Ren Yuxiao Zeng Qiang Tan Qiyou Li Xue Zhang Yajie Fang Yixiao Zhou Weitao Zhang Fang Chen Baishijiao Bian Yong Liu 
supported by the National Natural Science Foundation of China,Nos.82271132(to YL),82101167(to BB);the Natural Science Foundation of Chongqing,Nos.CSTB2022NSCQ-MSX0020(to BB),cstc2019jcyj-msxmX0473(to FC).
Our previous study demonstrated that combined transplantation of bone marrow mesenchymal stem cells and retinal progenitor cells in rats has therapeutic effects on retinal degeneration that are superior to transplanta...
关键词：DIFFERENTIATION inflammation mesenchymal stem cells MICROGLIA migration rat retinal degeneration retinal progenitor cells small extracellular vesicles stem cell transplantation 
A systematic review of progenitor survival and maturation in Parkinsonian models
《Neural Regeneration Research》2025年第11期3172-3178,共7页Giulia Comini Eilís Dowd 
supported by research grants from the Michael J Fox Foundation for Parkinson’s Research(grant numbers:17244 and 023410);Science Foundation Ireland(Grant Numbers:19/FFP/6554)(to ED)。
Stem cell-based brain repair is a promising emergent therapy for Parkinson's disease based on years of foundational research using human fetal donors as a cell source.Unlike current therapeutic options for patients,th...
关键词：cell replacement therapy DIFFERENTIATION embryonic stem cells GRAFT induced pluripotent stem cells Parkinson's disease SURVIVAL TRANSPLANT 
Characterizing and Stage-Wise Differentiation of Coal Spontaneous Combustion in Deep Mines
《Energy Engineering》2025年第4期1561-1580,共20页Haitao Wang Pengxin Zhang Weihao Li Baogang Li Xianghui Xiong 
This paper is supported by“Unveiling the List and Leading the Way”Science and Technology Research Project from Heilongjiang Province(2021ZXJ02A03);Major Science and Technology Support Action Plan for the“Millions”Project in Heilongjiang Province(2020ZX04A01);the Natural Science Foundation of Heilongjiang Province(LH2024E112).
Deep mining,characterized by high stress,elevated geothermal gradients,and significant moisture content,significantly increases the risk of Coal Spontaneous Combustion(CSC),posing a major threat to mine safety.This st...
关键词：Deep mine coal spontaneous combustion gas change rate index threshold 
Inhibition of IGF-1Rαaffects the differentiation fate of rat optic cup-derived retinal stem cells to retinal ganglion cells in vitro
《International Journal of Ophthalmology(English edition)》2025年第4期582-589,共8页Qi-You Li Xiao-Ling Tan Hai-Wei Xu Yu-Xiao Zeng Xiao-Yong Huang 
AIM:To explore the impact of insulin-like growth factor-1 receptorα(IGF-1Rα)on the differentiation fate of optic-cupderived retinal stem cells(OC-RSCs)into retinal ganglion cells(RGCs)in vitro.METHODS:OC-RSCs were i...
关键词：insulin-like growth factor-1 receptorα retinal ganglion cell rat optic cup retinal stem cells differentiation fate 
A high-resolution 20K SNP array for comprehensive genotyping and genetic mapping in Nicotiana tabacum L.
《The Crop Journal》2025年第2期630-635,共6页Shizhou Yu Zhixiao Yang Jie Zhang Linggai Cao Jie Liu Peng Lu Jiemeng Tao Jufen Wan Qingdong Zeng Tenghang Xu Peijian Cao Jingjing Jin Xueliang Ren 
supported by the Guizhou Provincial Basic Research Program(Natural Science)[(2024)648];the Program of China National Tobacco Corporation(110202101032(JY-09),110202201003(JY-03));the Program of Guizhou Branch of China National Tobacco Corporation(2023XM02,2021XM05,2022XM05,2024XM01).
Nicotiana tabacum(2n=4x=48),an economically important non-food crop and a model plant for genetic studies,faces challenges in efficient genotyping of novel germplasm.To address this,we developed the Ta-LD-SC,a 20K SNP...
关键词：Cultivated tobacco SNP array Population structure Differentiation patterns Breeding and genetic improvement 
Prophylactic treatment of Lacticaseibacillus paracasei K56 ameliorates asthma by regulating short-chain fatty acid production and Treg differentiation
《Food Science and Human Wellness》2025年第2期581-593,共13页Jiaqi Cui Yanfei Hong Wei-Hsien Liu Wen Zhao Xinmei Nan Xuekai Shang Yalan Li Haotian Feng Qiuyue Jiang Wei-Lian Hung Guiying Peng 
supported by grants from the National Natural Science Foundation of China(82174113,81473656);National Center of Technology Innovation for Dairy(No.2023-JSGG-15)。
Many studies have shown that the development of allergic asthma is associated with intestinal microbiota dysbiosis.Based on the gut-lung axis theory,probiotic intervention may be a potential strategy for respiratory d...
关键词：Lacticaseibacillus paracasei K56 Allergic asthma Gut-lung axis helper T cells Short-chain fatty acids 
The circadian clock orchestrates spermatogonial differentiation and fertilization by regulating retinoic acid signaling in vertebrates
《National Science Review》2025年第3期134-152,共19页Taole Liu Wei He Zhaomin Zhong Chenchen Lu Lianxin Wu Ziming Wang William Kojo Smith Quan Shi Qiaoming Long Han Wang 
supported by the National Key R&D Program of China(2019YFA0802400 and 2018YFA0801000);the National Basic Research Program of China(2012CB947600);the National Natural Science Foundation of China(31961133026,31871187,31030062,81570171 and 81070455);the Priority Academic Program Development(PAPD)of Jiangsu Higher Education Institutions.
The circadian clock generates and maintains~24-hour oscillations in almost all organs.The testis,however,remains mysterious,without a clear understanding of its circadian functions.Our time-series transcriptome analys...
关键词：TESTIS circadian clock SPERMATOGENESIS FERTILIZATION retinoic acid ZEBRAFISH mice 
Morphometric Differentiation between Four Strains of Japanese Quail (Coturnix coturnix japonica) Reared in Southern Côte d’Ivoire
《Open Journal of Animal Sciences》2025年第1期77-88,共12页Brahima Soro Isidore Kouadio Kpandji Sylvain Zadi Bopo Stéphane Yves Aka André N’guessan Yao Didier Paulin Sokouri 
The Japanese quail (Coturnix japonica) is a disease-resistant, high-productivity bird. It has few breeding constraints. A phenotypic characterization study of the Japanese quail was carried out in southern Côte d’Ivo...
关键词：QUAIL Coturnix japonica Phenotypic Characterization Improving 
Focal cortical dysplasia type Ⅱ:review of neuropathological manifestations and pathogenetic mechanisms
《Acta Epileptologica》2025年第1期32-44,共13页Yubao Fang Yaqian Zhang Tiancai Huang Shengyu Yang Yinchao Li Liemin Zhou 
supported by the Shenzhen Municipal Science and Technology key projects of the Basic Research Program(file no.LMZ JCYJ20220818102007015);the National Natural Science Foundation of China(file no.LMZ 82071447,82371456).
Focal cortical dysplasia(FCD)is an important cause of intractable epilepsy,with FCD type Ⅱ(FCD Ⅱ)being the most common subtype.FCD Ⅱ is characterized by cortical dyslamination accompanied by dysmorphic neurons(DNs)...
关键词：Focal cortical dysplasia Abnormal differentiation Gene mutations Epigenetic alterations 
A deeper and hotter Martian core-mantle differentiation inferred from FeO partitioning
《Science Bulletin》2025年第3期429-436,共8页Yunguo Li Chunhui Li You Zhou Yun Liu Huaiwei Ni 
the Strategic Priority Research Program(B)of the Chinese Academy of Sciences(XDB41000000);the Program for Innovative Research Team of USTC(WK3410000019);support of the National Natural Science Foundation of China(42322201,42173040);the support from CAs Hundred Talents Program.You Zhou acknowledges the support of the National Natural Science Foundation of China(41973063,42241142);computing system in the Supercomputing Center of University of Science and Technology of China.
The core-mantle differentiation process plays a pivotal role in redistributing material on a massive scale,shaping the long-term evolution of rocky planets.Understanding this process is crucial for gaining insights in...
关键词：MARS Core-mantle differentiation VOLATILE Partitioning 
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