TESTIS

作品数：406被引量：988H指数：14
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The circadian clock orchestrates spermatogonial differentiation and fertilization by regulating retinoic acid signaling in vertebrates
《National Science Review》2025年第3期134-152,共19页Taole Liu Wei He Zhaomin Zhong Chenchen Lu Lianxin Wu Ziming Wang William Kojo Smith Quan Shi Qiaoming Long Han Wang 
supported by the National Key R&D Program of China(2019YFA0802400 and 2018YFA0801000);the National Basic Research Program of China(2012CB947600);the National Natural Science Foundation of China(31961133026,31871187,31030062,81570171 and 81070455);the Priority Academic Program Development(PAPD)of Jiangsu Higher Education Institutions.
The circadian clock generates and maintains~24-hour oscillations in almost all organs.The testis,however,remains mysterious,without a clear understanding of its circadian functions.Our time-series transcriptome analys...
关键词：TESTIS circadian clock SPERMATOGENESIS FERTILIZATION retinoic acid ZEBRAFISH mice 
The SPARC-related modular calcium binding 1(Smoc1)regulated by androgen is required for mouse gubernaculum development and testicular descent
《Asian Journal of Andrology》2025年第1期44-51,共8页Zhi-Yi Zhao Yong Siow Ling-Yun Liu Xian Li Hong-Liang Wang Zhen-Min Lei 
supported in part by the Department of OB/GYN research funds(University of Louisville,Louisville,KY,USA);Jilin Province Health Technology Capability Enhancement funds(No.2022JC055).
Testicular descent occurs in two consecutive stages:the transabdominal stage and the inguinoscrotal stage.Androgens play a crucial role in the second stage by influencing the development of the gubernaculum,a structur...
关键词：ANDROGEN androgen receptor GUBERNACULUM Smoc1 testis descent 
How does Hedgehog signaling participate in the cross-interaction of hormones and testis development?
《BIOCELL》2025年第1期93-107,共15页JUN-JIE YU WAN-XI YANG 
supported in part by the National Natural Science Foundation of China(Nos.32270555 and 32072954).
Hedgehog(HH)signaling has been researched for decades and Hedgehog has 3 homologs:Sonic Hedgehog(Shh),Indian Hedgehog(Ihh),and Desert Hedgehog(Dhh).Dhh is the one involved in male gonad and germ cell development.The d...
关键词：Hedgehog signaling HORMONE TESTIS Leydig cell Gonadal dysgenesis 
Testis tissue cryopreservation may be considered in boys with cryptorchidism
《Asian Journal of Andrology》2024年第6期610-616,共7页Linn Salto Mamsen Simone Hildorf Elissavet Ntemou Danyang Wang Dina Cortes Jens Fedder Jørgen Thorup Claus Yding Andersen 
financially supported by the University Hospital of Copenhagen,Rigshospitalet,the Danish Child Cancer Foundation(2021-7395);Vissing Fonden(519140 AHO/PPT);the Research Fund between Rigshospitalet and Odense University Hospital(136-A5544).
This study assessed the feasibility of testis tissue cryopreservation (TTC) for fertility preservation in prepubescent boys with cryptorchidism. From January 2014 to December 2022, the University Hospital of Copenhage...
关键词：cryopreservation of testis tissue CRYPTORCHIDISM fertility preservation germ cells male infertility prepubescent spermatogonial stem cells TESTIS 
Central precocious puberty should be taken seriously in children with Leydig cell tumors of the testis after surgical treatment:a tertiary center experience
《Asian Journal of Andrology》2024年第6期617-621,共5页Pei Liu Zong-Han Li Hong-Cheng Song Chun-Xiu Gong Wei-Ping Zhang 
Central precocious puberty secondary to Leydig cell tumors is rare in children. We retrospectively analyzed the mid- to long-term follow-up data of patients with Leydig cell tumors. The clinical data of 12 consecutive...
关键词：follow-up studies Leydig cell tumor precocious puberty TESTIS 
Simvastatin enhanced growth and altered testis transcriptome profiles of male tilapias
《Aquaculture and Fisheries》2024年第6期893-899,共7页Zituo Yang Fei Sun Le Wang Gen Hua Yue 
supported by the internal fund of the Temasek Life Sciences Laboratory,Singapore.
Simvastatin(SIM),a commonly prescribed drug for lowering serum-lipid,has been detected in many aquatic environments.Exposure to high concentrations of SIM in rats and aquatic organisms resulted in toxicity to hepatocy...
关键词：Fish STATIN GROWTH Reproduction AQUACULTURE 
SUN5, a testis-specific nuclear membrane protein, participates in recruitment and export of nuclear mRNA in spermatogenesis
《Acta Biochimica et Biophysica Sinica》2024年第11期1673-1686,共14页Xiyi He Yunfei Zhang Zenghui Mao Gang Liu Lihua Huang Xiaowen Liu Yuyan Su Xiaowei Xing 
This work was supported by the grants from the open research fund of Hunan Provincial Key Laboratory of Regional Hereditary Birth Defects Prevention and Control(No.HPKL2023006);the Hunan Provincial Natural Science Foundation of China(No.2023JJ30854);the Natural Science Foundation of Changsha Municipal,Hunan Province,China(No.kq2208354);the Undergraduate and Graduate Student Independent Exploration Innovation Fund of Central South University(Nos.1053320214303 and 1053320215869).
SUN5,a testis-specific gene,is associated with acephalic spermatozoa syndrome(Ass).Here,we demonstrate that SUN5 is involved in mRNA export.In Sun5-knockout mice(Sun5^(-/-)),poly(A)+RNA accumulates in the nuclei of ge...
关键词：SUN5 hnRNPs Nup93 Nxf1 mRNAexport 
RpL38 modulates germ cell differentiation by controlling Bam expression in Drosophila testis
《Science China(Life Sciences)》2024年第11期2411-2425,共15页Yang Fang Fengchao Zhang Fangzhen Zhao Jiajia Wang Xinkai Cheng Fei Ye Jiayu He Long Zhao Ying Su 
supported by the Laoshan Laboratory(LSKJ202203204);the National Natural Science Foundation of China(32170832,32170541);the Fundamental Research Funds for Central Universities,China(202012004).
Switching from mitotic spermatogonia to meiotic spermatocytes is critical to producing haploid sperms during male germ cell differentiation.However,the underlying mechanisms of this switch remain largely unexplored.In...
关键词：Drosophila melanogaster SPERMATOGENESIS RpL38 SPERMATOGONIA BAM 
New genes driven by segmental duplications share a testis-specific expression pattern in the chromosome-level genome assembly of tree sparrow
《Integrative Zoology》2024年第5期1004-1008,共5页Shengnan WANG Yue SHEN Zhaocun LIN Yuquan MIAO Chengqi WANG Wenya ZHANG Yingmei ZHANG 
supported by the National Natural Science Foundation of China(No.31572216);the Foundation for Excellent Doctoral Student of Gansu Province(No.22JR5RA413).
The origination of new genes is a fundamental question in genome evolution,and gene duplication is one of the most important mechanisms for the formation of new genes(Ohno 1970;Long et al.2003;Kaessmann 2010;Ding et a...
关键词：al. SEGMENTAL pattern 
Comparative transcriptomic analysis of ovary and testis reveals sex-related genes in roughskin sculpin Trachidermus fasciatus
《Journal of Oceanology and Limnology》2024年第5期1673-1682,共10页Dongxiu XUE Sudong XIA Tengfei XING Yuqian GAO Jinxian LIU 
Supported by the National Natural Science Foundation of China(Nos.31972793,31502169);the Key Scientific Research Project in Universities and Colleges in Tianjin(No.2022ZD004)。
The mechanisms underlying sex determination and differentiation have long intrigued researchers in the fields of development and evolutionary biology.The roughskin sculpin(Trachidermus fasciatus Heckel),displaying sex...
关键词：Trachidermus fasciatus TRANSCRIPTOME OVARY TESTIS sex-related gene 
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