How does Hedgehog signaling participate in the cross-interaction of hormones and testis development?  

作　　者：JUN-JIE YU WAN-XI YANG 

机构地区：[1]The Sperm Laboratory,College of Life Sciences,Zhejiang University,Hangzhou,310058,China

出　　处：《BIOCELL》2025年第1期93-107,共15页生物细胞(英文)

基　　金：supported in part by the National Natural Science Foundation of China(Nos.32270555 and 32072954).

摘　　要：Hedgehog(HH)signaling has been researched for decades and Hedgehog has 3 homologs:Sonic Hedgehog(Shh),Indian Hedgehog(Ihh),and Desert Hedgehog(Dhh).Dhh is the one involved in male gonad and germ cell development.The distribution of molecules in Hedgehog signaling in testis indicated that Hedgehog signaling executes important functions during testis development.The patients with Dhh signaling deficiency develop dysgenesis of gonads and hormone production which demands further exploration of gonad HH signaling.Some results proved the indispensable roles of HH signaling in gonad and germ cell development and the interaction with hormones.This review evaluates HH functions in the testis and how HH affects and is affected by hormones and provides novel insights about HH signaling to the readers.

关 键 词：Hedgehog signaling HORMONE TESTIS Leydig cell Gonadal dysgenesis 

分 类 号：R394[医药卫生—医学遗传学]