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Therapeutic potential of exercise-hormone irisin in Alzheimer's disease: 《Neural Regeneration Research》2025年第6期1555-1564,共10页Eunhee Kim Rudolph ETanzi Se Hoon Choi; supported by Cure Alzheimer’s Fund (to RET and SHC);JPB Foundation (to RET),and R56AG072054 (to SHC)。; Irisin is a myokine that is generated by cleavage of the membrane protein fibronectin type Ⅲ domain-containing protein 5(FNDC5) in response to physical exercise. Studies reveal that irisin/FNDC5 has neuroprotective f...; 关键词：Alzheimer's disease EXERCISE fibronectin typeⅢdomain-containing protein 5(FNDC5) irisin

Increased hormone activity promotes silk development and heat tolerance during the floret differentiation stage in maize: 《The Crop Journal》2025年第2期545-555,共11页Huiqin Wang Jing Sun Hao Ren Bin Zhao Yuting Li Zishan Zhang Baizhao Ren Aziz Khan Jiwang Zhang Yinglong Chen Peng Liu; supported by the National Natural Science Foundation of China(32071959);the National Key Research and Development Program of China(2023YFD2303304);the Key Research and Development Program of Shandong Province(LJNY202103);the Shandong Province Key Agricultural Project for Application Technology Innovation(SDAIT02-08)to Peng Liu.; Heat stress,a major challenge in modern agriculture due to global warming,significantly reduces crop productivity.To mitigate its adverse effects on maize yield,it is crucial to understand the mechanisms by which heat...; 关键词：Zea mays L Heat stress TRANSCRIPTOMICS HORMONES SILK

A novel model of central precocious puberty disease:Paternal MKRN3 gene-modified rabbit: 《Animal Models and Experimental Medicine》2025年第3期511-522,共12页Bangzhu Chen Xing Ye Lihao Chen Tianping Liu Guiling Li Chula Sa Juan Li Ke Liu Weiwang Gu Gang Wang; National Natural Science Foundation of China,Grant/Award Number:82101937;Guangdong Medical Science and Technology Research Fund Project,China,Grant/Award Number:B2024069;Guangzhou Science and Technology Plan Project,China,Grant/Award Number:2024A04J4923 and SL2023A04J02229。; Background:Makorin ring finger protein 3 gene(MKRN3)gene mutation is the most common genetic cause of central precocious puberty(CPP)in children.Due to the lack of ideal MKRN3-modified animal model(MKRN3-modified mice...; 关键词：central precocious puberty gonadotropin inhibiting hormone(GnIH) gonadotropin releasing hormone(GnRH) MKRN3 RABBIT

Raptin, a sleep-induced hypothalamic hormone, suppresses appetite and obesity: 《Cell Research》2025年第3期165-185,共21页Ling-Qi Xie Biao Hu Ren-Bin Lu Ya-Lun Cheng Xin Chen Jie Wen Yao Xiao Yu-Ze An Ning Peng Yu Dai Genqing Xie Qi Guo Hui Peng Xiang-Hang Luo; supported by the National Natural Science Foundation of China(92149306,82120108009,81930022,82270911,82201746,82430028);Projects of International Cooperation and Exchanges NSFC(82120108009);Major Project of Natural Science Foundation of Hunan Province(Open Competition)(2021JC0002);the Scientific Research Program of FuRong Laboratory(2024PT5104).; Sleep deficiency is associated with obesity,but the mechanisms underlying this connection remain unclear.Here,we identify a sleep-inducible hypothalamic protein hormone in humans and mice that suppresses obesity.This ...; 关键词：sleep induced hypothalamic hormone raptin OBESITY sleep deficiency RETICULOCALBIN sleep deficien suprachiasmatic nucleus vasopressin expressing neurons

Metabolic dysfunction-associated steatotic liver disease and type 2 diabetes:A dual threat to cardiac dysfunction progression: 《World Journal of Cardiology》2025年第1期118-120,共3页Wei Wang Charlie Cooper; Metabolic dysfunction-associated steatotic liver disease(MASLD),particularly in patients with type 2 diabetes mellitus(T2DM),is increasingly recognized as a multi-system disease that affects both hepatic and cardiovas...; 关键词：Metabolic dysfunction-associated steatotic liver disease Type 2 diabetes Cardiac dysfunction Left ventricular mass Sex-hormone binding protein Fibrosis-4 index scores

How does Hedgehog signaling participate in the cross-interaction of hormones and testis development?: 《BIOCELL》2025年第1期93-107,共15页JUN-JIE YU WAN-XI YANG; supported in part by the National Natural Science Foundation of China(Nos.32270555 and 32072954).; Hedgehog(HH)signaling has been researched for decades and Hedgehog has 3 homologs:Sonic Hedgehog(Shh),Indian Hedgehog(Ihh),and Desert Hedgehog(Dhh).Dhh is the one involved in male gonad and germ cell development.The d...; 关键词：Hedgehog signaling HORMONE TESTIS Leydig cell Gonadal dysgenesis

De novo patients with high-volume metastatic hormone-sensitive prostate cancer can benefit from the addition of docetaxel to triplet therapy:Network-analysis and systematic review: 《Chinese Medical Journal》2025年第2期231-233,共3页Hanxu Guo Chengqi Jin Li Ding Jun Xie Jing Xu Ruiliang Wang Hong Wang Changcheng Guo Jiansheng Zhang Bo Peng Xudong Yao Jing Yuan Bin Yang; funded by grants from the Shanghai Science Committee Foundation(No.19411967700);the National Natural Science Foundation of China(No.31570993);the Wu Jieping Medical Foundation(No.320.6750.2020-14-7).; To the Editor:In recent years,the treatment for metastatic hormone-sensitive prostate cancer(mHSPC)has undergone rapid developments.Docetaxel(DOC)or androgen receptor-targeted agent(ARTA)and androgen deprivation thera...; 关键词：triplet therapy network meta analysis DOCETAXEL androgen deprivation therapy adt systemic therapiesmultiple overall survival progression free survival

Correlation between Anti Mullerian Hormone (Amh), Antral Follicule Count and the Response to Ovarian Stimulation in Infertile Women in Douala: 《Open Journal of Obstetrics and Gynecology》2025年第1期147-166,共20页Bilkissou Moustapha Tatah Humphry Neng Nancy Elage Munge Yannick R. Onana Yaneu Junie Ngaha Diane Kamdem Jean Marie Alima Alphonse Ngalame Georges Mangala Astrid Ndolo Gervais Mounchikpou Michelle Mendoua Aimée Timnou Djokam Tchounzou Robert Michel Roger Ekono Henri Essome Charlotte Nguefack Tchente; Background: The use of assisted reproductive technique (ART) is becoming more common in infertility. During ART most patients undergo ovarian stimulation. In this study we study the correlation between ovarian reserve...; 关键词：Ovarian Stimulation AMH AFC Ovarian Reserve Correlation and Prediction Value

Patient-reported outcomes of rezvilutamide versus bicalutamide in combination with androgen deprivation therapy in high-volume metastatic hormone-sensitive prostate cancer patients (CHART): a randomized, phase 3 study: 《Signal Transduction and Targeted Therapy》2025年第1期360-368,共9页Hongkai Wang Shusuan Jiang Hong Luo Fangjian Zhou Dalin He Lulin Ma Hongqian Guo Chaozhao Liang Tie Chong Jun Jiang Zhiwen Chen Yong Wang Qing Zou Ye Tian Jun Xiao Jian Huang Jinchao Chen Qiang Dong Xiaoping Zhang Hanzhong Li Xinfeng Yang Jianpo Lian Wenliang Wang Dingwei Ye; The randomized phase 3 CHART trial(NCT03520478)revealed that rezvilutamide(REZ)plus androgen deprivation therapy(ADT)in high-volume,metastatic,hormone-sensitive prostate cancer(mHSPC)significantly enhanced radiographi...; 关键词：patients cancer RANDOMIZED

Binding interaction of typical emerging contaminants on Gobiocypris rarus transthyretin:an in vitro and in silico study: 《Frontiers of Environmental Science & Engineering》2024年第11期53-64,共12页Xiangqiao Li Huihui Liu Songshan Zhao Peter Watson Xianhai Yang; supported by the National Natural Science Foundation of China(No.22176097);the Fundamental Research Funds for the Central Universities(China)(No.30923011032).; Emerging contaminants(ECs)have drawn global concern,and the endocrine disrupting chemicals is one of the highly interested ECs categories.However,numerous ECs lacks the basic information about whether they can disturb...; 关键词：Endocrine disrupting effects Hormone transporter Endocrine disrupting chemicals Disinfection byproducts Classification model

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