Therapeutic potential of exercise-hormone irisin in Alzheimer's disease  

作　　者：Eunhee Kim Rudolph ETanzi Se Hoon Choi 

机构地区：[1]Genetics and Aging Research Unit,MassGeneral Institute for Neurodegenerative Disease,Department of Neurology,Massachusetts General Hospital,Harvard Medical School,Charlestown,MA,USA [2]McCance Center for Brain Health,Massachusetts General Hospital,Boston,MA,USA

出　　处：《Neural Regeneration Research》2025年第6期1555-1564,共10页中国神经再生研究（英文版）

基　　金：supported by Cure Alzheimer’s Fund (to RET and SHC);JPB Foundation (to RET),and R56AG072054 (to SHC)。

摘　　要：Irisin is a myokine that is generated by cleavage of the membrane protein fibronectin type Ⅲ domain-containing protein 5(FNDC5) in response to physical exercise. Studies reveal that irisin/FNDC5 has neuroprotective functions against Alzheimer's disease, the most common form of dementia in the elderly, by improving cognitive function and reducing amyloid-β and tau pathologies as well as neuroinflammation in cell culture or animal models of Alzheimer's disease. Although current and ongoing studies on irisin/FNDC5 show promising results, further mechanistic studies are required to clarify its potential as a meaningful therapeutic target for alleviating Alzheimer's disease. We recently found that irisin treatment reduces amyloid-β pathology by increasing the activity/levels of amyloid-β-degrading enzyme neprilysin secreted from astrocytes. Herein, we present an overview of irisin/FNDC5's protective roles and mechanisms against Alzheimer's disease.

关 键 词：Alzheimer's disease EXERCISE fibronectin typeⅢdomain-containing protein 5(FNDC5) irisin 

分 类 号：R749.16[医药卫生—神经病学与精神病学]