Raptin, a sleep-induced hypothalamic hormone, suppresses appetite and obesity  

作　　者：Ling-Qi Xie Biao Hu Ren-Bin Lu Ya-Lun Cheng Xin Chen Jie Wen Yao Xiao Yu-Ze An Ning Peng Yu Dai Genqing Xie Qi Guo Hui Peng Xiang-Hang Luo 

机构地区：[1]Department of Endocrinology,Endocrinology Research Center,Xiangya Hospital of Central South University,Changsha,Hunan,China [2]Department of Endocrinology,The First People’s Hospital of Xiangtan City,Xiangtan,Hunan,China [3]National Clinical Research Center for Geriatric Disorders,Xiangya Hospital,Changsha,Hunan,China [4]Key Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment,Ministry of Education,Xiangya Hospital,Central South University,Changsha,Hunan,China [5]FuRong Laboratory,Changsha,Hunan,China

出　　处：《Cell Research》2025年第3期165-185,共21页细胞研究(英文版)

基　　金：supported by the National Natural Science Foundation of China(92149306,82120108009,81930022,82270911,82201746,82430028);Projects of International Cooperation and Exchanges NSFC(82120108009);Major Project of Natural Science Foundation of Hunan Province(Open Competition)(2021JC0002);the Scientific Research Program of FuRong Laboratory(2024PT5104).

摘　　要：Sleep deficiency is associated with obesity,but the mechanisms underlying this connection remain unclear.Here,we identify a sleep-inducible hypothalamic protein hormone in humans and mice that suppresses obesity.This hormone is cleaved from reticulocalbin-2(RCN2),and we name it Raptin.Raptin release is timed by the circuit from vasopressin-expressing neurons in the suprachiasmatic nucleus to RCN2-positive neurons in the paraventricular nucleus.Raptin levels peak during sleep,which is blunted by sleep deficiency.Raptin binds to glutamate metabotropic receptor 3(GRM3)in neurons of the hypothalamus and stomach to inhibit appetite and gastric emptying,respectively.Raptin-GRM3 signaling mediates anorexigenic effects via PI3K-AKT signaling.Of note,we verify the connections between deficiencies in the sleeping state,impaired Raptin release,and obesity in patients with sleep deficiency.Moreover,humans carrying an RCN2 nonsense variant present with night eating syndrome and obesity.These data define a unique hormone that suppresses food intake and prevents obesity.

关 键 词：sleep induced hypothalamic hormone raptin OBESITY sleep deficiency RETICULOCALBIN sleep deficien suprachiasmatic nucleus vasopressin expressing neurons 

分 类 号：R338[医药卫生—人体生理学]