DOCETAXEL

作品数：232被引量：513H指数：10
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相关机构：南京军区南京总医院北京大学南京大学医学院附属鼓楼医院南京大学更多>>
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Development and Validation of a UPLC Method for the Determination of Docetaxel and Its Related Substances in Pharmaceutical Dosage Forms, an Antineoplastic Agent
《American Journal of Analytical Chemistry》2024年第10期333-346,共14页Srinivasulu Kasa Sreenivas Pippalla Mopidevi Narasimha Naidu Dipak Goyal 
A novel, simple, and sensitive Ultra Performance Liquid Chromatography (UPLC) method was developed and validated for the quantification of process-related impurities and degradants, as well as the assay of Docetaxel. ...
关键词：UPLC Method Development VALIDATION DOCETAXEL IMPURITIES ICH 
Acute severe hypokalemia caused by treatment of tongue squamous cell carcinoma with docetaxel and cisplatin:A case report
《World Journal of Clinical Oncology》2024年第10期1309-1314,共6页Hong-Mei Jiang Rong Sun Bing-Jie Ning Xue-Qin Yang Xiao-Ju Zhu 
Supported by the Chongqing medical scientific research project(a joint project of the Chongqing Health Commission and Science and Technology),No.2020ZY023716.
BACKGROUND The tongue squamous cell carcinoma(TSCC)is an oral malignant tumor arising from the squamous epithelium of the tongue mucosa,characterized by a high malignant degree,invasive growth,early lymph node metasta...
关键词：Tongue squamous cell carcinoma DOCETAXEL HYPOKALEMIA HYPOMAGNESEMIA Case report 
Effect of PD-1/PD-L1 immune checkpoint inhibitor in squamous and nonsquamous non-small cell lung cancer:A systematic review and meta-analysis
《Malignancy Spectrum》2024年第3期197-204,共8页Zhenjie Dai Jing Chen Yong Wang 
supported by the Postdoctoral Foundation of West China Hospital, Sichuan University (2020HXBH102)
Background: The effects of programmed cell death protein 1/programmed cell death ligand 1(PD-1/PD-L1) immune checkpoint inhibitors(ICIs) in patients with squamous and nonsquamous non-small cell lung cancer(NSCLC) rema...
关键词：PD‐1/PD‐L1 immune checkpoint inhibitor DOCETAXEL nonsquamous and squamous NSCLC meta‐analysis 
AZGP1P2/UBA1/RBM15 Cascade Mediates the Fate Determinations of Prostate Cancer Stem Cells and Promotes Therapeutic Effect of Docetaxel in Castration-Resistant Prostate Cancer via TPM1 m6A Modification
《Research》2024年第3期151-167,共17页Hong Wang Jj Liu Xiaojun Zhu Bin Yang Zuping He Xudong Yao 
grants from the National Natural Science Foundation of China(81802554 and 32170862);the Experimental Animal Fund of Shanghai Science and Technology Commission(22140903800);a Project Funded by China Postdoctoral Science Foundation(2021M692432).
Prostate cancer(PCa)is a common malignant tumor with high morbidity and mortality worldwide.The prostate cancer stem cell(PCSC)model provides novel insights into the pathogenesis of PCa and its therapeutic response.Ho...
关键词：PROSTATE TPM1 m6A 
Network meta-analysis of combination strategies in metastatic hormone-sensitive prostate cancer被引量：1
《Asian Journal of Andrology》2024年第4期402-408,共7页Shan-Shan Wang Xiao-Jie Bian Jun-Long Wu Bei-He Wang Sheng Zhang Ding-Wei Ye 
the Clinical Research Plan of SHDC(No.SHDC2020CR2016B);the Scientific Innovation Project of Shanghai Education Committee(No.2021-01-07-00-07-E00080);the National Natural Science Foundation of China(No.81902568).
This study compared different doublet and triplet therapies for efficacy and safety in metastatic hormone-sensitive prostate cancer(mHSPC).PubMed,EMBASE,and the Cochrane Library were comprehensively searched for eligi...
关键词：androgen antagonist androgen receptor antagonist DOCETAXEL META-ANALYSIS prostatic neoplasm 
FOXP3 targets KIF5A to increase lactate production and promote docetaxel resistance in lung adenocarcinoma
《Acta Biochimica et Biophysica Sinica》2024年第7期1011-1021,共11页Liangliang Dong Chan Feng Wenwen Cheng Aihua Huang Kejing Ying 
supported by the grants from the Medical and Health Program of Zhejiang Province,China(No.2018251155);the National Science Foundation of Zhejiang Province(No.LTGY23H010006).
A prominent cause of cancer-related fatalities with a poor prognosis is lung adenocarcinoma(LUAD).KIF5A,a crucial member of the kinesin superfamily,is linked to drug resistance in malignancies.This work aims to invest...
关键词：KIF5A FOXP3 lung adenocarcinoma LACTATE DOCETAXEL 
CircTHSD4 promotes the malignancy and docetaxel (DTX) resistance in prostate cancer by regulating miR-203/HMGA2 axis被引量：1
《Oncology Research》2024年第3期529-544,共16页JIANYUN XIE LINIE LU JIALI ZHANG QIRUI LI WEIDONG CHEN 
Fujian Provincial Health and Middleaged and Young Backbone Talents Training Project“The role and Mechanism of C53 in mcRPC Treatment of Drug Resistance”(2019-ZQN-77).
Objective:Circular ribose nudeic acids(circRNAs)are implicated in tumor progression and drug resistance of prostate cancer(PCa).The current work explored the function of circ_0005203(aircTHSD4)in the malignancy and do...
关键词：circTHSD4 Docetaxel resistance Prostate cancer miR-203 HMGA2 
IMpower210:A phase Ⅲ study of second-line atezolizumab vs. docetaxel in East Asian patients with non-small cell lung cancer
《Chinese Journal of Cancer Research》2024年第2期103-113,共11页Yi-Long Wu Shun Lu Gongyan Chen Jianxing He Jifeng Feng Yiping Zhang Liyan Jiang Hongming Pan Jianhua Chang Jian Fang Amy Cai Lilian Bu Jane Shi Jinjing Xia 
funded by F. Hoffmann-La Roche Ltd. F. Hoffmann-La Roche Ltd sponsored the IMpower210 study。
Objective: IMpower210(NCT02813785) explored the efficacy and safety of single-agent atezolizumab vs.docetaxel as second-line treatment for advanced non-small cell lung cancer(NSCLC) in East Asian patients.Methods: Key...
关键词：Atezolizumab East Asia non-small cell lung cancer programmed death-ligand 1 inhibitors monoclonal antibody 
The effect of lengths of branched-chain fatty alcohols on the efficacy and safety of docetaxel-prodrug nanoassemblies
《Acta Pharmaceutica Sinica B》2024年第3期1400-1411,共12页Shuo Wang Tian Liu Yuetong Huang Chaoying Du Danping Wang Xiyan Wang Qingzhi Lv Zhonggui He Yinglei Zhai Bingjun Sun Jin Sun 
financially supported by National Key R&D Program of China(No.2022YFE0111600);National Natural Science Foundation of China(No.82272151 and 82204318);Doctoral Scientific Research Staring Foundation of Liaoning Province(No.2021-BS-130,China);General Program of Department of Education of Liaoning Province(No.LJKZ0953,China);Shenyang Young and Middle-aged Science and Technology Innovation Talents Support Program(RC220389,China)。
The self-assembly prodrugs are usually consisted of drug modules,activation modules,and assembly modules.Keeping the balance between efficacy and safety by selecting suitable modules remains a challenge for developing...
关键词：PRODRUGS NANOASSEMBLIES Self-assembly Branched-chain fatty alcohols Disulfide bond DOCETAXEL Efficacy Safety 
Ritonavir reverses resistance to docetaxel and cabazitaxel in prostate cancer cells with acquired resistance to docetaxel
《Cancer Drug Resistance》2024年第1期1029-1052,共24页Eric van der Putten Katja Wosikowski Jos H.Beijnen Gábor Imre Colin R.Freund 
supported by Modra Pharmaceuticals B.V..No other financial grants were provided.
Aim:Docetaxel is a microtubule-stabilizing drug used for the treatment of several cancers,including prostate cancer.Resistance to docetaxel can either occur through intrinsic resistance or develop under therapeutic pr...
关键词：Prostate cancer docetaxel resistance cabazitaxel resistance P-GP ritonavir 
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