NANOASSEMBLIES

作品数：39被引量：79H指数：5
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Shape effect of prodrug nanoassemblies on treatment efficacy of cancer therapy
《Nano Research》2025年第2期616-626,共11页Fengxiang Liu Rongzheng Liu Xiaoyuan Fan Xia Wang Kaiyuan Wang Hainan Zhao Hao Ye Shunzhe Zheng Xiao Kuang Yinxian Yang Haotian Zhang Qiming Kan Zhonggui He Jian Chen Jin Sun 
This research was supported by National Natural Science Foundation of China(Nos.82273874 and 82404561);Liaoning Revitalization Talents Program(No.XLYC22202019);the China National Postdoctoral Program for Innovative Talents(No.BX20240233);the Postdoctoral Fellowship Program(Grade B)of China Postdoctoral Science Foundation(No.GZB20240179);the China Postdoctoral Science Foundation(No.2023MD744230);Doctoral Scientific Research Launching Fund Project of Liaoning province(No.2024-BS-075);Prospective Basic research project of 2024 Scientific Research Project of Liaoning Department of Education(No.LJ212410163042).
The tumor microenvironment-sensitive prodrug-based nanoparticles(NPs)have emerged as a promising drug delivery system(DDS).The shape of these particles plays a crucial role in their in vivo behavior.However,non-spheri...
关键词：CAMPTOTHECIN SELF-ASSEMBLY prodrug-based nanoparticles nanorod cancer therapy 
Branched module-modified SN38 prodrug nanoassemblies for improved colorectal cancer therapy:Effectively balance efficacy and safety
《Nano Research》2025年第1期572-585,共14页Qing Wang Shiyi Zuo Shufang Zheng Cuiyun Liu Yaqiao Li Jiayu Guo Danping Wang Shuo Wang Wenjing Wang Bowen Zhang Minglong Huang Xianbao Shi Jin Sun Zhonggui He Bingjun Sun 
gotapproval from the Institutional Animal Ethical Care Committee(IAEC)of Shenyang Pharmaceutical University(ethical code:SYPU-IACUC-2022-0302-010).
The clinical utility of irinotecan is restricted by individual variability in carboxylesterase expression.Direct administration of its active metabolite,7-ethyl-10-hydroxycamptothecin(SN38),presents an appealing alter...
关键词：IRINOTECAN SN38 prodrug nanoassemblies disulfide bonds branched aliphatic chains 
Binary prodrug nanoassemblies combining chemotherapy and ferroptosis activation for efficient triple-negative breast cancer therapy被引量：2
《Chinese Chemical Letters》2024年第10期348-352,共5页Lin Li Bingjun Sun jin Sun Lin Chen Zhonggui He 
supported by the National Nature Science Foundation of China(No.81803029);the Science and Technology Foundation of Yuzhong District,Chongqing(No.20210179);the Nature Science Foundation of Chongqing(No.cstc2021jcyjmsxmX1089)。
Chemotherapy has been recommended as the standard protocol for triple-negative breast cancer(TNBC)at the advanced stage.However,the current treatment is unsatisfactory due to inefficient drug accumulation and rapid ch...
关键词：Prodrug nanoassemblies PACLITAXEL Ferroptosis LAT1 Triple-negative breast cancer 
Engineering hyaluronic acid-based nanoassemblies for monoclonal antibody delivery-design,characterization,and biological insights
《Nano Research》2024年第10期9111-9125,共15页Ana M.López-Estévez Y.Zhang María Medel Iker Arriaga Lucía Sanjurjo Cristian Huck-Iriart Nicola G.A.Abrescia María J.Vicent Defang Ouyang Dolores Torres María José Alonso 
supported by the government of Xunta de Galicia(Competitive Reference Groups,Consellería de Educación e Ordenación Universitaria,Xunta de Galicia,No.ED431C 2021/17);by the ISCⅢ thorough AES 2020,Award No.AC20/00028 and within the framework of EuroNanoMed Ⅲ;part of the project Proof of Concept(No.PDC2021-120929-I00);financed by the Spanish Ministry of Science and Innovation-AEI/10.13039/501100011033;the European Union NextGenerationEU/PRTR;the Spanish Ministry of Science,Innovation and Universities(No.FPU18/00095).
The current spotlight of cancer therapeutics is shifting towards personalized medicine with the widespread use of monoclonal antibodies(mAbs).Despite their increasing potential,mAbs have an intrinsic limitation relate...
关键词：monoclonal antibody NANOPARTICLES hyaluronic acid CHARACTERIZATION particle size computational modeling 
Fine-tuning the structure-tolerance-antitumor efficacy axis of prodrug nanoassemblies via branched aliphatic functionalization被引量：1
《Nano Research》2024年第4期2908-2918,共11页Guanting Li Fengli Xia Hongying Xiao Shunzhe Zheng Shuwen Fu Han Qiao Qianhui Jin Xuanbo Zhang Dun Zhou Chutong Tian Jin Sun Zhonggui He Bingjun Sun 
supported by National Natural Science Foundation of China(Nos.82272151,82204318 and 82173766);Doctoral Scientific Research Staring Foundation of Liaoning Province(No.2021-BS-130);General Program of Department of Education of Liaoning Province(No.LJKZ0953);Shenyang Young and Middle-aged Science and Technology Innovation Talent Support Program(No.RC220389).
Small-molecule prodrug nanoassemblies have emerged as efficient antitumor drug delivery systems.However,in the case of camptothecins-based prodrug nanoassemblies,linear aliphatic side chain modification often results ...
关键词：prodrug nanoassembly self-assembly antitumor efficacy TOLERANCE 7-ethyl-10-hydroxycamptothecin(SN_(3)8) 
The effect of lengths of branched-chain fatty alcohols on the efficacy and safety of docetaxel-prodrug nanoassemblies
《Acta Pharmaceutica Sinica B》2024年第3期1400-1411,共12页Shuo Wang Tian Liu Yuetong Huang Chaoying Du Danping Wang Xiyan Wang Qingzhi Lv Zhonggui He Yinglei Zhai Bingjun Sun Jin Sun 
financially supported by National Key R&D Program of China(No.2022YFE0111600);National Natural Science Foundation of China(No.82272151 and 82204318);Doctoral Scientific Research Staring Foundation of Liaoning Province(No.2021-BS-130,China);General Program of Department of Education of Liaoning Province(No.LJKZ0953,China);Shenyang Young and Middle-aged Science and Technology Innovation Talents Support Program(RC220389,China)。
The self-assembly prodrugs are usually consisted of drug modules,activation modules,and assembly modules.Keeping the balance between efficacy and safety by selecting suitable modules remains a challenge for developing...
关键词：PRODRUGS NANOASSEMBLIES Self-assembly Branched-chain fatty alcohols Disulfide bond DOCETAXEL Efficacy Safety 
Ce6 nanoassemblies:Molecular mechanism and strategies for combinational anticancer therapy Special Collection:Aggregation-Induced Processes and Functions
《Aggregate》2024年第1期130-147,共18页Yuwei Liu Shuting Xu Qingyang Lyu Yi Huang Weiping Wang 
National Natural Science Foundation of China,Grant/Award Number:82222903;Li Ka Shing Faculty of Medicine(Start-up Fund)of The University of Hong Kong.
Nowadays,cancer has become the leading cause of death worldwide,driving the need for effective therapeutics to improve patient prognosis.Photodynamic therapy(PDT)has been widely applied as an antitumor modality,owing ...
关键词：cancer treatment carrier-free chlorin e6(Ce6) light NANOMEDICINE photodynamic therapy(PDT) SELFASSEMBLY 
Emerging advances in plasmonic nanoassemblies for biosensing and cell imaging
《Chinese Chemical Letters》2023年第9期15-24,共10页Jin Wang Chen Wang Jing-Juan Xu Xing-Hua Xia Hong-Yuan Chen 
supported by grants from the National Natural Science Foundation of China(Nos.22022412,22274076,21874155);the Primary Research&Development Plan of Jiangsu Province(No.BE2022793)。
Integrating discrete plasmonic nanoparticles into assemblies can induce plasmonic coupling that produces collective plasmonic properties,which are not available for single nanoparticles.Theoretical analysis revealed t...
关键词：Plasmonic nanoasssembly Dark-field imaging Plasmonic circular dichroism Surface-enhanced Raman scattering BIOSENSING Cell imaging 
Tumor-responsive dynamic nanoassemblies for boosted photoimmunotherapy被引量：1
《Nano Research》2023年第8期11125-11138,共14页Dao Shi Nan Wang Jie Zhang Xi Hu Qiyue Wang Ruixue Xiao Baoyue Ding Fangyuan Li Daishun Ling 
This work was funded by the National Key Research and Development Program of China(Nos.2022YFB3203804,2022YFB3203801,and 2022YFB3203800);the Leading Talent of“Ten Thousand Plan”-National High-Level Talents Special Support Plan,National Natural Science Foundation of China(Nos.32071374 and 32000985);Program of Shanghai Academic Research Leader under the Science and Technology Innovation Action Plan(No.21XD1422100);Program of Shanghai Science and Technology Development(No.22TS1400700);Zhejiang Provincial Natural Science Foundation of China(Nos.LR22C100001 and LQ21H300003);Innovative Research Team of High-Level Local Universities in Shanghai(No.SHSMUZDCX20210900);CAS Interdisciplinary Innovation Team(No.JCTD-2020-08)。
Photoimmunotherapy(PIT)is an emerging therapeutic approach that integrates phototherapy and immunotherapy to eliminate primary tumors under an appropriate dosage of local light irradiation,while simultaneously prevent...
关键词：photoimmunotherapy tumor-responsive dynamic nanoassemblies immunosuppressive tumor microenvironment 
Triboelectric nanogenerator based on electrodeposited Ag octahedral nano-assemblies
《Journal of Energy Chemistry》2023年第8期478-495,I0012,共19页M.Edith Navarro-Segura Margarita Sanchez-Dominguez Ana Arizmendi-Morquecho J.Alvarez-Quintana 
Consejo Nacional de Ciencia y Tecnología of México (CONACYT) for her Doctoral scholarship;postgraduate studies department at CIMAVMonterrey for fellowship support。
The tremendous potential of triboelectric generators-TENGs for converting mechanical energy into electrical energy places them as one of the most promising energy harvesting technologies. In this work, the fabrication...
关键词：Triboelectric generator Nanostructured electrodeposited electrodes Ag octahedral nanoassemblies Electrode surface structure 
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