Tumor-responsive dynamic nanoassemblies for boosted photoimmunotherapy  

作　　者：Dao Shi Nan Wang Jie Zhang Xi Hu Qiyue Wang Ruixue Xiao Baoyue Ding Fangyuan Li Daishun Ling 

机构地区：[1]Frontiers Science Center for Transformative Molecules,School of Chemistry and Chemical Engineering,National Center for Translational Medicine,State Key Laboratory of Oncogenes and Related Genes,Shanghai Jiao Tong University,Shanghai 200240,China [2]Institute of Pharmaceutics,Hangzhou Institute of Innovative Medicine,College of Pharmaceutical Sciences,Zhejiang University,Hangzhou 310058,China [3]Department of Pharmaceutics,Jiaxing Key Laboratory for Photonanomedicine and Experimental Therapeutics,College of Medicine,Jiaxing University,Jiaxing 314001,China [4]World Laureates Association(WLA)Laboratories,Shanghai 201203,China [5]School of Pharmacy,Anhui University of Chinese Medicine,Hefei 230012,China [6]Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumor of Zhejiang Province,Hangzhou 310009,China

出　　处：《Nano Research》2023年第8期11125-11138,共14页纳米研究（英文版）

基　　金：This work was funded by the National Key Research and Development Program of China(Nos.2022YFB3203804,2022YFB3203801,and 2022YFB3203800);the Leading Talent of“Ten Thousand Plan”-National High-Level Talents Special Support Plan,National Natural Science Foundation of China(Nos.32071374 and 32000985);Program of Shanghai Academic Research Leader under the Science and Technology Innovation Action Plan(No.21XD1422100);Program of Shanghai Science and Technology Development(No.22TS1400700);Zhejiang Provincial Natural Science Foundation of China(Nos.LR22C100001 and LQ21H300003);Innovative Research Team of High-Level Local Universities in Shanghai(No.SHSMUZDCX20210900);CAS Interdisciplinary Innovation Team(No.JCTD-2020-08)。

摘　　要：Photoimmunotherapy(PIT)is an emerging therapeutic approach that integrates phototherapy and immunotherapy to eliminate primary tumors under an appropriate dosage of local light irradiation,while simultaneously preventing tumor metastasis and recurrence by activating the host antitumor immune response.Tumor-responsive dynamic nanoassemblies(TDNs)have evolved from being a mere curiosity to a promising platform for high-performance PIT.However,the dynamic nano-bio interaction between TDNs and tumor microenvironment remains poorly understood,which shall be critical for precise control of TDNs assembling/disassembling behavior and superior PIT efficacy.To deepen the understanding of the structure–function relationship of TDNs,this review introduces the rational design,nano-bio interactions,and controllable functionalities of cutting-edge TDNs for enhanced PIT.Moreover,the synergetic mechanism between TDNs-based PIT and immunomodulatory agents-mediated immunomodulation is particularly emphasized.Finally,the challenges and future perspectives in this emerging field are assessed.

关 键 词：photoimmunotherapy tumor-responsive dynamic nanoassemblies immunosuppressive tumor microenvironment 

分 类 号：R730.51[医药卫生—肿瘤]