云南高校图书馆联盟文献共享服务平台- IRINOTECAN

IRINOTECAN: 作品数：99被引量：401H指数：10; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：谭华冯继峰孙晓非许立功管忠震更多>>; 相关机构：天津市滨江医院北京大学肿瘤医院哈尔滨医科大学江苏省肿瘤医院更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划广东省自然科学基金湖北省自然科学基金更多>>

Branched module-modified SN38 prodrug nanoassemblies for improved colorectal cancer therapy:Effectively balance efficacy and safety: 《Nano Research》2025年第1期572-585,共14页Qing Wang Shiyi Zuo Shufang Zheng Cuiyun Liu Yaqiao Li Jiayu Guo Danping Wang Shuo Wang Wenjing Wang Bowen Zhang Minglong Huang Xianbao Shi Jin Sun Zhonggui He Bingjun Sun; gotapproval from the Institutional Animal Ethical Care Committee(IAEC)of Shenyang Pharmaceutical University(ethical code:SYPU-IACUC-2022-0302-010).; The clinical utility of irinotecan is restricted by individual variability in carboxylesterase expression.Direct administration of its active metabolite,7-ethyl-10-hydroxycamptothecin(SN38),presents an appealing alter...; 关键词：IRINOTECAN SN38 prodrug nanoassemblies disulfide bonds branched aliphatic chains

Comparison of irinotecan/carboplatin versus etoposide/carboplatin for extended disease small cell lung cancer(ED-SCLC):A systematic review and meta-analysis of randomized controlled trials: 《Malignancy Spectrum》2024年第4期300-311,共12页Zeeshan Afzal Sara Hira Xia Song Na Wang; Background:Platinum-based chemotherapy in addition to the nonplatinum agent etoposide is the standard of care for extensive-stage small cell lung cancer(ES-SCLC).However,the front-line chemotherapy regimen is not know...; 关键词：CARBOPLATIN ED-SCLC ETOPOSIDE IRINOTECAN small cell lung cancer

Targeted inhibition of Gus-expressing Enterococcus faecalis to promote intestinal stem cell and epithelial renovation contributes to the relief of irinotecan chemotoxicity by dehydrodiisoeugenol: 《Acta Pharmaceutica Sinica B》2024年第12期5286-5304,共19页Ruiyang Gao Bei Yue Cheng Lv Xiaolong Geng Zhilun Yu Hao Wang Beibei Zhang Fangbin Ai Ziyi Wang Donghui Liu Zhengtao Wang Kaixian Chen Wei Dou; supported by the National Natural Science Foundation of China(No.82274329,82304991,82130115);the China Postdoctoral Science Foundation(No.2023M732336);the Shanghai Science and Technology Committee Sailing Program Foundation(No.23YF1442500,China).; Irinotecan(CPT11)chemotherapy-induced diarrhea affects a substantial cancer population due to b-glucuronidase(Gus)converting 10-O-glucuronyl-7-ethyl-10-hydroxycamptothecin(SN38G)to toxic 7-ethyl-10-hydroxycamptothecin...; 关键词：IRINOTECAN Intestinal mucositis b-Glucuronidase Enterococcus faecalis Intestinal stem cells Epithelial regeneration Gus bacteriaehost eirinotecan axis Dehydrodiisoeugenol

SALIRI-based(raltitrexed plus irinotecan)therapy as a second-line treatment for patients with metastatic colorectal cancer(SALLY):A prospective,multicenter,non-interventional,registry study: 《Cancer Communications》2024年第8期910-914,共5页Shuqui Qin Jin Li Aiping Zhou Yanqiao Zhang Xianglin Yuan Liangjun Zhu Baoli Qin Shan Zeng Lin Shen Ying Yuan Weibo Wang Jun Liang Xianwen Zhang Feng Ye Ping Chen HuaizhangWang Zhenyan Yu Lu Yue Yong Fang Jianping Xiong Jianwei Yang Yiye Wan Xianli Yin Wenling Wang Nong Xu XiaohongWang Zemin Xiao Huafang Su YingWang Kangsheng Gu Shuiping Tu Zishu Wang Bo Liu Xiaohua Hu Weixian Liu Xiaofeng Li; Primary chemotherapy options for colorectal cancer(CRC)involve four key drugs:fluorouracils(5-FU),oxaliplatin,irinotecan and raltitrexed.The first-line regimen consists of 5-FU and leucovorin combined with oxaliplatin...; 关键词：drugs chemotherapy FOLFIRI

Cisplatin increases carboxylesterases through increasing PXR mediated by the decrease of DEC1: 《The Journal of Biomedical Research》2023年第6期431-447,共17页Minqin Xu Lihua Zhang Lan Lin Zhiyi Qiang Wei Liu Jian Yang; The work was supported by the National Natural Science Foundation of China(Grant Nos.82073934 and 81872937)to J.Y.; cis-Diamminedichloroplatinum(CDDP)is widely used for the treatment of various solid cancers.Here we reported that CDDP increased the expression and enzymatic activities of carboxylesterase 1(CES1)and carboxylesterase ...; 关键词：cis-diamminedichloroplatinum pregnane X receptor differentiated embryonic chondrocyte-expressed gene 1 carboxylesterase 1 carboxylesterase 2 IRINOTECAN

伊立替康(Irinotecan)对SCA3细胞模型的影响: 《西安文理学院学报（自然科学版）》2023年第4期59-62,69,共5页王子见陈添钰张豆豆何树妮李繁尤欢欢; 陕西省大学生创新创业项目(S202111080043):“蒿甲醚通过激活p38信号通路调控ataxin-3核转运的分子机制研究”;陕西省大学生创新创业项目(S202111080031):“天麻素对SCA3细胞模型的影响”;陕西省大学生创新创业项目(6457):“蒿甲醚和天麻素联合用药对SCA3细胞模型的影响”;国家自然科学基金项目(82202067):“基于AKT/GSK3β信号通路探讨蒿甲醚调控ataxin-3入核在SCA3治疗中的作用机制”;西安市科技计划项目(2020KJWL04):“秦岭药用植物天麻的神经保护作用研究”;院长基金项目(YZJJ202104):“蒿甲醚通过HSP60信号通路调控ataxin-3聚集体发挥神经保护作用的机制研究”。; 伊立替康(Irinotecan,CPT-11)是一种治疗癌症的化疗药物,主要代谢产物为7-乙基-10羟基喜树碱(7-Ethyl-10-hydroxycamptothecin,SN38).课题组实验筛选结果表明伊立替康对ataxin-3核质转运有潜在影响.通过免疫荧光、微孔过滤分析以及Preto...; 关键词：伊立替康 SCA3 ATAXIN-3 细胞毒性

Full-profile pharmacokinetics, anticancer activity and toxicity of an extended release trivalent PEGylated irinotecan prodrug被引量：1: 《Acta Pharmaceutica Sinica B》2023年第8期3444-3453,共10页Shiwen Song Dong Sun Hong Wang Jinliang Wang Huijing Yan Xuan Zhao John Paul Fawcett Xin Xu Deqi Cai Jingkai Gu; supported by the National Natural Science Foundation of China(Grant Nos.82030107 and 81872831);the National Science and Technology Major Projects for significant new drugs creation of the 13th five-year plan(2017ZX09101001 and 2018ZX09721002007,China)。; Irinotecan is an anticancer topoisomerase I inhibitor that acts as a prodrug of the active metabolite,SN-38.Unfortunately,the limited utility of irinotecan is attributed to its pH-dependent stability,short half-life a...; 关键词：IRINOTECAN SN-38 Trivalent PEGylated irinotecan PRODRUG Full-profile pharmacokinetics

Research on Liposomal Irinotecan in Combination with 5-FU/LV for Metastatic Pancreatic Ductal Adenocarcinoma: 《Asian Journal of Social Pharmacy》2023年第2期128-136,共9页Wang Wenjun Wang Yaoling Huang Zhe; Objective To systematically review the published clinical and economic research on liposomal irinotecan in combination with 5-FU/LV for metastatic pancreatic ductal adenocarcinoma(mPDAC)at home and abroad.Methods PubM...; 关键词：liposomal irinotecan metastatic pancreatic ductal adenocarcinoma(mPDAC) CHEMOTHERAPY clinical research economic evaluation

Impact of prior chemotherapy with two different fluoropyrimidines on the efficacy of capecitabine plus irinotecan or FOLFIRI with or without bevacizumab in metastatic colorectal cancer:a post hoc analysis of the AXEPT study被引量：1: 《Cancer Communications》2023年第4期519-522,共4页Satoru Iwasa Zi-Xian Wang Kei Muro Satoshi Morita Young Suk Park Dongsheng Zhang Yasuhide Yamada Junichi Sakamoto TaeWon Kim; Dear Editor,Recently,the phase III Asian XELIRI(capecitabine plus irinotecan)ProjecT(AXEPT)study demonstrated the non-inferiority of modified capecitabine plus irinotecan(mXELIRI)±bevacizumab(Bev)to fluorouracil plus...; 关键词：FOLFIRI colorectal METASTATIC

Oxaliplatin plus irinotecan vs irinotecan as second-line treatment in pancreatic cancer patients:a randomized–controlled open-label Phase II study: 《Gastroenterology Report》2023年第1期224-229,共6页Hangyu Zhang Zhou Tong Lulu Liu Qihan Fu Xudong Zhu Xiaomeng Dai Xuanwen Bao Weijia Fang Yi Zheng Peng Zhao; supported by National Natural Science Foundation of China(NSFC)[82074208];National Natural Science Foundation of China(NSFC)[81472346];Natural Science Foundation of Zhejiang Province[LY20H160033];Clinical trial registration:ClinicalTrials.gov(NCT02558868).; Background:Limited second-line therapeutic options are available for metastasis pancreatic cancer(mPC).We aimed to explore the efficacy and safety of oxaliplatin plus irinotecan(IROX)in mPC patients.Methods:This is an...; 关键词：pancreatic cancer second-line chemotherapy randomized control trial IRINOTECAN IROX

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