PRODRUG

作品数：211被引量：334H指数：7
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相关领域：医药卫生更多>>
相关作者：张礼和杨振军赵玉芬陈益崔永梅更多>>
相关机构：北京大学上海大学信息技术有限公司郑州大学更多>>
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相关基金：国家自然科学基金中国博士后科学基金国家重点基础研究发展计划湖北省自然科学基金更多>>
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Supramolecular prodrug vesicles for selective antimicrobial therapy employing a chemo-photodynamic strategy
《Chinese Chemical Letters》2025年第3期267-271,共5页Hao Sun Shengke Li Qian Liu Minzan Zuo Xueqi Tian Kaiya Wang Xiao-Yu Hu 
supported by the National Natural Science Foundation of China(No.22271154);Natural Science Foundation of Jiangsu Province(No.BK20211179);Innovation Support Program of Jiangsu Province(No.BZ2023055);Fundamental Research Funds for the Central Universities(No.NS2023033);China Postdoctoral Science Foundation(No.2023M731658);Achievement Transformation Project of Qinghai Province(No.2021-SF-145).
Supramolecular prodrug vesicles(H-4⊃B-2@MB)with selective antibacterial activity have been successfully constructed.Specifically,a natural antibiotic prodrug(B-2)with glutathione(GSH)-responsiveness was synthesized.Th...
关键词：Supramolecular prodrug Selective antibacterial activity Host-guest complex CAVITAND Combination therapy 
Sodium cholesterol sulfate mediated mitoxantrone prodrug electrostatic nanocomplexes:achieving the therapeutic efficacy and safety of mitoxantrone
《Science China Chemistry》2025年第3期1185-1198,共14页Erwei Zhao Lingxiao Li Jingyi Zhang Yaqiao Li Rong Chai Bowen Zhang Jialin Xing Minglong Huang Lurong Zhang Xiaohui Pu Zhonggui He Bingjun Sun 
financial support from National Natural Science Foundation of China (82272151,82173766,and 82204318);Liaoning Revitalization Talents Program (XLYC2203083);Shenyang Young and Middle-aged Science and Technology Innovation Talent Support Program (RC220389)。
Forming electrostatic nanocomplexes(ENCs)with counter-ions can improve the delivery efficiency of chemotherapy drugs.However,water-soluble chemotherapy drugs like mitoxantrone(MTO),have limited affinity for counter-io...
关键词：MITOXANTRONE PRODRUG sodium cholesterol sulfate electrostatic nanocomplexes disulfide bond 
An azo bond primary cleavage and C–C bond secondary cleavage-based polymeric β-lapachone prodrug for selective anti-cancer therapy
《Science China Materials》2025年第2期640-651,共12页Weidong Zhao Mengfei Zheng Hongyu Chu Jingxuan Zhang Kun Wang Chenguang Yang Na Shen Zhaohui Tang 
financially supported by the Ministry of Science and Technology of the People’s Republic of China (2022YFE0110200);the National Natural Science Foundation of China (52025035, 52273157, and 52073279);the Department of Science and Technology of Jilin Province (20240305041YY and 20230508102RC);the Youth Innovation Promotion Association of the Chinese Academy of Sciences (2022224)。
β-Lapachone (β-Lap) is a promising orthonaphthoquinone drug for cancer treatment and has been inclinical trials. Its application is constrained by the low aqueoussolubility, and severe side effects. Even prodrug des...
关键词：β-lapachone NQO1 C-C bond cleavage polymeric nanoprodrug azo linkage 
Shape effect of prodrug nanoassemblies on treatment efficacy of cancer therapy
《Nano Research》2025年第2期616-626,共11页Fengxiang Liu Rongzheng Liu Xiaoyuan Fan Xia Wang Kaiyuan Wang Hainan Zhao Hao Ye Shunzhe Zheng Xiao Kuang Yinxian Yang Haotian Zhang Qiming Kan Zhonggui He Jian Chen Jin Sun 
This research was supported by National Natural Science Foundation of China(Nos.82273874 and 82404561);Liaoning Revitalization Talents Program(No.XLYC22202019);the China National Postdoctoral Program for Innovative Talents(No.BX20240233);the Postdoctoral Fellowship Program(Grade B)of China Postdoctoral Science Foundation(No.GZB20240179);the China Postdoctoral Science Foundation(No.2023MD744230);Doctoral Scientific Research Launching Fund Project of Liaoning province(No.2024-BS-075);Prospective Basic research project of 2024 Scientific Research Project of Liaoning Department of Education(No.LJ212410163042).
The tumor microenvironment-sensitive prodrug-based nanoparticles(NPs)have emerged as a promising drug delivery system(DDS).The shape of these particles plays a crucial role in their in vivo behavior.However,non-spheri...
关键词：CAMPTOTHECIN SELF-ASSEMBLY prodrug-based nanoparticles nanorod cancer therapy 
Branched module-modified SN38 prodrug nanoassemblies for improved colorectal cancer therapy:Effectively balance efficacy and safety
《Nano Research》2025年第1期572-585,共14页Qing Wang Shiyi Zuo Shufang Zheng Cuiyun Liu Yaqiao Li Jiayu Guo Danping Wang Shuo Wang Wenjing Wang Bowen Zhang Minglong Huang Xianbao Shi Jin Sun Zhonggui He Bingjun Sun 
gotapproval from the Institutional Animal Ethical Care Committee(IAEC)of Shenyang Pharmaceutical University(ethical code:SYPU-IACUC-2022-0302-010).
The clinical utility of irinotecan is restricted by individual variability in carboxylesterase expression.Direct administration of its active metabolite,7-ethyl-10-hydroxycamptothecin(SN38),presents an appealing alter...
关键词：IRINOTECAN SN38 prodrug nanoassemblies disulfide bonds branched aliphatic chains 
Synergistic metabolic modulation of fibroblast-like synoviocytes via targeted dual prodrug nanoparticles to mitigate rheumatoid arthritis
《Acta Pharmaceutica Sinica B》2025年第1期542-556,共15页Shaobing Li Juntao Lin Chengxinqiao Wang Junhan Liu Yupeng Wang Yan Chen Dongfang Zhou 
supported by grants from the National Key Research and Development Program of China(2022YFC3601900/2022YFC3601902);the National Natural Science Foundation of China(22275081,82372117);the Guangdong Basic and Applied Basic Research Foundation(2024A1515011462,2022A1515011292 and 2024A1515010464);the China Postdoctoral Science Foundation(2022M711532 and 2022T150302).
Elevated glucose metabolism is a prominent characteristic of fibroblast-like synoviocytes(FLS)in rheumatoid arthritis(RA).However,the efficacy of inhibiting a single target of glucose metabolism in FLS using small mol...
关键词：Dual prodrug nanoparticles Metabolic modulation Fibroblast-like synoviocytes Rheumatoid arthritis Glucose transporter member 1 Glycolytic enzyme Lactic acid Synovial microenvironment 
A self-reinforced activatable photosensitizer prodrug enabling synergistic photodynamic and chemotherapy
《Smart Molecules》2024年第4期197-204,共8页Daipeng Huang Jikai Yin Yang Zou Haiqiao Huang Saran Long Wen Sun Jianjun Du Jiangli Fan Xiaojun Peng 
supported by National Natural Science Foundation of China(22090011);Liaoning Binhai Laboratory(LBLB-2023-03);Fundamental Research Funds for the Central Universities(DUT22LAB608).
As a novel drug development paradigm,selective activation of prodrugs provides the potential for precise tumor chemotherapy,thereby presenting an opportunity for advancing cancer treatment.The combination of photodyna...
关键词：cell apoptosis CHEMOTHERAPY GLUTATHIONE photodynamic therapy PRODRUG 
Cooperative bond scission by HRP/H_(2)O_(2)for targeted prodrug activation
《Chinese Chemical Letters》2024年第12期399-404,共6页Yunkang Tong Haiqiao Huang Haolan Li Mingle Li Wen Sun Jianjun Du Jiangli Fan Lei Wang Bin Liu Xiaoqiang Chen Xiaojun Peng 
the National Natural Science Foundation of China(No.22090011);the Fundamental Research Funds for China Central Universities(No.DUT22LAB608)for financial support。
The prodrug strategy provides an opportunity for improving the therapeutic index of drugs and avoid ing their side effects.The main challenge lies in the fast and effective release of the parent drugs at the desired s...
关键词：PRODRUG ENZYME Tumor microenvironment Hydrogen peroxide Photodynamic therapy Fluorescent probe 
Advancements and challenges in immunocytokines:A new arsenal against cancer
《Acta Pharmaceutica Sinica B》2024年第11期4649-4664,共16页Wenqiang Shi Nan Liu Huili Lu 
Natural Science Foundation of Chongqing(2022NSCQ-MSX2319 to Dr.Huili Lu,China);Science&Technology Commission of Shanghai Municipality(Nos.21S11906300 and 23ZR1431800 to Dr.Huili Lu,China).
Immunocytokines,employing targeted antibodies to concentrate cytokines at tumor sites,have shown potential advantages such as prolonged cytokine half-lives,mitigated adverse effects,and synergistic antitumor efficacy ...
关键词：Immunocytokines Bifunctional fusion proteins Combination therapy Cytokine engineering Tumor-conditional PRODRUG 
Binary prodrug nanoassemblies combining chemotherapy and ferroptosis activation for efficient triple-negative breast cancer therapy被引量：2
《Chinese Chemical Letters》2024年第10期348-352,共5页Lin Li Bingjun Sun jin Sun Lin Chen Zhonggui He 
supported by the National Nature Science Foundation of China(No.81803029);the Science and Technology Foundation of Yuzhong District,Chongqing(No.20210179);the Nature Science Foundation of Chongqing(No.cstc2021jcyjmsxmX1089)。
Chemotherapy has been recommended as the standard protocol for triple-negative breast cancer(TNBC)at the advanced stage.However,the current treatment is unsatisfactory due to inefficient drug accumulation and rapid ch...
关键词：Prodrug nanoassemblies PACLITAXEL Ferroptosis LAT1 Triple-negative breast cancer 
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