GLUTATHIONE

作品数：439被引量：1085H指数：15
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相关机构：中国科学院中国药科大学华中师范大学沈阳农业大学更多>>
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Ferrocene conjugated glutathione consumption for enhanced ferroptosis therapy and chemotherapy
《Nano Research》2025年第4期364-374,共11页Limei Zhang Huatai Zhu Yuting Ren Peng Ye Jiandu Lei 
supported by the Fundamental Research Funds for the Central Universities(No.PTYX202449).
As the backbone of tumor therapy,chemotherapy is prone to tumor resistance due to its apoptotic pathway.Ferroptosis,as an effective form of non-apoptotic cell death,can overcome chemotherapy apoptosis-induced resistan...
关键词：ferroptosis glutathione consumption ferrocene(Fc) honokiol(HNK) hydroxycamptothecin(HCPT) 
Effects of glutathione on oocyte and embryo development in in vitro fertilization
《Asian pacific Journal of Reproduction》2025年第1期38-46,共9页Herry Sonjaya Erni Damayanti Hikmayani Iskandar Sudirman Baco Hasbi Hasbi Andi Mujnisa Kusumandari Indah Prahesti Aulia Uswa Noor Khasanah Sri Firmiaty Asma’ul Fitriana Nurhidayah Ekayanti Mulyawati Kaiin Daud Samsudewa Rukman Pala Fitra Aji Pamungkas Herdis Herdis 
This study was financially supported by Universitas Hasanuddin through Penelitian Fundamental Kolaboratif(PFK)(letter of appointment number:00323/UN4.22/PT.0103/2023).
Objective:To evaluate the effect of glutathione(GSH)supplementation in maturation and adaptation media on oocyte development,embryo quality,and oocyte viability after vitrification.Methods:The GSH concentrations were ...
关键词：Bali cattle EMBRYO Gluthatione OOCYTE VITRIFICATION 
Sulfur metabolism under stress:Oxidized glutathione inhibits methionine biosynthesis by destabilizing the enzyme cystathionineγ-synthase
《Journal of Integrative Plant Biology》2025年第1期87-100,共14页Yael Hacham Alex Kaplan Elad Cohen Maayan Gal Rachel Amir 
supported by the Israel Science Foundation(ISF Grant no.1857/20);Binational Agricultural Research&Development(BARD Grant no.IS-4248-09 R)。
Cysteine is the precursor for the biosynthesis of glutathione,a key stress-protective metabolite,and methionine,which is imperative for cell growth and protein synthesis.The exact mechanism that governs the routing of...
关键词：cystathionineγ-synthase(CGS) CYSTEINE GLUTATHIONE metabolic competition METHIONINE oxidative stress sulfur metabolism TOBACCO 
Self-assembled co-delivery system of gold nanoparticles and paclitaxel based on in-situ dynamic covalent chemistry for synergistic chemo-photothermal therapy
《Rare Metals》2025年第1期417-429,共13页Xiao-Xia Wu Ding-Hu Zhang Yi-Nan Ding Fei Cao Yang Li Jun-Lie Yao Xin-Yu Miao Lu-Lu He Jun Luo Jian-Wei Li Jie Lin Ai-Guo Wu Jia-Ping Zheng 
supported by the National Natural Science Foundation of China(Nos.82202274,82072032,22161016,32025021,12374390,52002380 and 31971292),the National Science and Technology Major Project(No.2023ZD0500902);the Fellowship of China Postdoctoral Science Foundation(No.2023M743559);the Member of Youth Innovation Promotion Association Foundation of CAS,China(No.2023310);the Key Scientific and Technological Special Project of Ningbo City(No.2023Z209);the Natural Science Foundation of Zhejiang Province(No.LQ23H180003)。
Recently,stimuli-responsive nanocarriers capable of precision drug release have garnered significant attention in the field of drug delivery.Here,an in-situ dynamic covalent self-assembled(DCS)strategy was utilized to...
关键词：in-situ dynamic covalent self-assembly(DCS) Disulfide macrocycles Host-guest interaction Glutathione(GSH)stimuli-response Chemo-photothermal therapy 
Hollow MnO_(2)-based multifunctional nanoplatform for enhanced tumor chemodynamic therapy
《Science China Materials》2025年第1期292-302,共11页Dejie Ge Debao Ren Yamin Duan Xuan Luo Shuailin He Wenjun Qin Fei Wang Wen Yin Lixin Ma Yong Yang Cheng Zhang 
National Natural Science Foundation of China(32301105);Open Project Funding of the State Key Laboratory of Biocatalysis and Enzyme Engineering(SKLBEE20230020)。
The inherent tumor microenvironment(TME)of hypoxia and high glutathione(GSH)hinders the production of reactive oxygen species(ROS),yet which are crucial roles to make the oxygen-independent chemodynamic therapy(CDT)ou...
关键词：hollow manganese dioxide sulfate radical GLUTATHIONE chemodynamic therapy tumor therapy 
A self-reinforced activatable photosensitizer prodrug enabling synergistic photodynamic and chemotherapy
《Smart Molecules》2024年第4期197-204,共8页Daipeng Huang Jikai Yin Yang Zou Haiqiao Huang Saran Long Wen Sun Jianjun Du Jiangli Fan Xiaojun Peng 
supported by National Natural Science Foundation of China(22090011);Liaoning Binhai Laboratory(LBLB-2023-03);Fundamental Research Funds for the Central Universities(DUT22LAB608).
As a novel drug development paradigm,selective activation of prodrugs provides the potential for precise tumor chemotherapy,thereby presenting an opportunity for advancing cancer treatment.The combination of photodyna...
关键词：cell apoptosis CHEMOTHERAPY GLUTATHIONE photodynamic therapy PRODRUG 
AKR1C1 interacts with STAT3 to increase intracellular glutathione and confers resistance to oxaliplatin in colorectal cancer
《Acta Pharmaceutica Sinica B》2024年第12期5305-5320,共16页Zhiwen Fu Tingting Wu Chen Gao Lulu Wang Yu Zhang Chen Shi 
supported by the National Natural Science Foundation of China(Grant Nos.82204758 and 82073402).
Oxaliplatin(OXA),a platinum-based chemotherapeutic agent,remains a mainstay in first-line treatments for advanced colorectal cancer(CRC).However,the eventual development of OXA resis-tance represents a significant cli...
关键词：Oxaliplatin resistance AKR1C1 Colorectal cancer ALANTOLACTONE GLUTATHIONE Combination therapy Natural product CHEMORESISTANCE 
Thioredoxin pathway regulated live-cell synthesis of CdSe quantum dots in Saccharomyces cerevisiae
《Science China Chemistry》2024年第11期3851-3860,共10页Xu Li Cai-Qin Wu Jia-Wei Tu Juan Kong Ling-Ling Yang Zhi-Xiong Xie Dai-Wen Pang 
supported by the National Natural Science Foundation of China (22293030, 22293032);the National Key Research and Development Program of China (2019YFA0210100);the Fundamental Research Funds for the Central Universities of China (63211023)。
Currently, the application of synthetic biology to artificially manipulate and utilize organisms for the synthesis of desired products such as nanomaterials with excellent fluorescence properties is attracting conside...
关键词：THIOREDOXIN GLUTATHIONE quantum dot live-cell synthesis selenium metabolism Saccharomyces cerevisiae 
Dietary glycine supplementation enhances syntheses of creatine and glutathione by tissues of hybrid striped bass(Morone saxatilis ♀ × Morone chrysops ♂) fed soybean meal-based diets
《Journal of Animal Science and Biotechnology》2024年第5期1996-2011,共16页Wenliang He Xinyu Li Guoyao Wu 
supported by Agriculture and Food Research Initiative Competitive Grants(2022-67015-36200)from the USDA National Institute of Food and Agriculture。
Background We recently reported that supplementing glycine to soybean meal-based diets is necessary for the optimum growth of 5-to 40-g(Phase-I)and 110-to 240-g(Phase-II)hybrid striped bass(HSB),as well as their intes...
关键词：Amino acids CREATINE Fish GLUTATHIONE GLYCINE Nutrition 
Bmo-miR-3351 modulates glutathione content and inhibits BmNPV proliferation by targeting BmGSTe6 in Bombyx mori
《Insect Science》2024年第5期1378-1396,共19页Hui-Hua Cao Wei-Wei Kong Bing Ling Zhi-Yi Wang Ying Zhang Zhe-Xiao Guo Shi-Huo Liu Jia-Ping Xu 
This study was supported by the National Natural Science Foundation of China(Project No.31973002);the International Cooperation Project of Anhui Province(No.202104b11020002);the Foundation for Innovative Research Groups of Anhui Agricultural University(ANRC2019032).
MicroRNAs(miRNAs)are small non-coding RNAs that play pivotal roles in the host response to invading pathogens.Among these pathogens,Bombyx mori nu-cleopolyhedrovirus(BmNPV)is one of the main causes of substantial econ...
关键词：BMNPV Bombyx mori GLUTATHIONE glutathione S-transferase microRNA 
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