National Natural Science Foundation of China(Grant Nos.32070838 and 82301874);Open Fund of State Key Laboratory of Reproductive Medicine,Nanjing Medical University(Grant No.SKLRM K202102)。
Meiotic resumption in mammalian oocytes involves nuclear and organelle structural changes,notably the chromatin configuration transition from a non-surrounding nucleolus(NSN)to surrounding nucleolus(SN)in germinal ves...
supported by the National Key Research and Development Program of China(2023YFD1300502);the Fundamental Research Funds for the Central Universities of China(KYT2024002,KJJQ2024003,and RENCAI2024011);the National Natural Science Foundation of China(32370908).
Mitochondrial Rho-GTPase 1(MIRO1)is an outer mitochondrial membrane protein which regulates mitochondrial transport and mitophagy in mitosis.In present study,we reported the crucial roles of MIRO1 in mammalian oocyte ...
The livestock sector is a vital component of India's agricultural economy,providing essential support to rural communities and ensuring food security.Efficient reproductive performance is critical to sustaining livest...
This study was financially supported by Universitas Hasanuddin through Penelitian Fundamental Kolaboratif(PFK)(letter of appointment number:00323/UN4.22/PT.0103/2023).
Objective:To evaluate the effect of glutathione(GSH)supplementation in maturation and adaptation media on oocyte development,embryo quality,and oocyte viability after vitrification.Methods:The GSH concentrations were ...
supported by National Natural Science Foundation of China(32570854);Science and Technology Program of Guangzhou,China(2023A03J0258);Guangdong Basic and Applied Basic Research Foundation,China(2023B1515120027)。
CtBP-interacting protein(CtIP)is known for its multifaceted roles in DNA repair and genomic stability,directing the homologous recombination-mediated DNA double-stranded break repair pathway via DNA end resection,an e...
supported by the National Key Research and Development Program of China (No.2021YFC3200803);the National Natural Science Foundation of China (No.21976138).
Quaternary ammonium compounds (QACs) become emerging pollutants and their toxicities earn increasing attention.So far,their reproductive toxicities were poorly investigated,and their effects over generations were even...
supported by the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement No 860960;by Bijzonder Onderzoeksfonds GOA(Geconcerteerde onderzoeksacties)2018000504(GOA030-18 BOF);supported by the Research Foundation Flanders(FWO)(grant numbers:1228821N and 12A2H24N)。
Background Within the follicular fluid,extracellular vesicles(EVs)guide oocyte growth through their cargo microRNAs(miRNAs).Here,we inv estigated the role of EVs and their cargo miRNAs by linking the miRNAs found in E...
supported by the National Key Research and Development Program of China(No.2021YFD1200403);the National Natural Science Foundation of China(No.32072735);Xigaze City regional Science and technology Collaborative innovation project-Genetic resources of rescue protection for Zhangmu goat(No.QYXTZX-RKZ2023-06)。
Background Previous studies have shown that the vitrification of metaphaseⅡ(MⅡ)oocytes significantly represses their developmental potential.Abnormally increased oxidative stress is the probable factor;however,the u...
Objective:To investigate the potential relationships among the ovarian response prediction index(ORPI),follicle-oocyte index(FOI),and clinical pregnancy rate(CPR)in women undergoing their first in vitro fertilization/...
supported by the National R&D program of China(2022YFC2703500);the Science and Technology Program of Guangzhou,China(202201020292 and 2023A03J0258);the Natural Science Foundation of Shandong Province(ZR2021ZD33);the Strategic Collaborative Research Program of the Ferring Institute of Reproductive Medicine,Ferring Pharmaceuticals and Chinese Academy of Sciences(FIRMC181101).
Environmental factors such as diet and lifestyle can influence the health of both mothers and offspring.However,its transgenerational transmission and underlying mechanisms remain largely unknown.Here,using a maternal...