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Assessment of the transcriptomic consequences and MAU2 protein levels in edited induced pluripotent stem cells with NIPBL pathogenic variants: 《Genes & Diseases》2025年第3期68-71,共4页Kévin Cassinari Anne Rovelet-Lecrux Céline Derambure Myriam Vezain Sophie Coutant Anne-Claire Richard Nathalie Drouot Juliette Coursimault Gabriella Vera Alice Goldenberg Pascale Saugier-Veber Camille Charbonnier Gaël Nicolas; the Institutional Review Board of the Rouen University Hospital(CERDE notification E2023-65).; Cornelia de Lange Syndrome(CdLS)is an intellectual disability syndrome characterized by distinctive clinical features including growth retardation,limb malformation,and a characteristic facial dysmorphism.1 Six genes,...; 关键词：gene expression regulation growth retardationlimb mau protein levels nipbl pathogenic variants facial dysmorphism transcriptomic consequences organizing chromatin intellectual disability syndrome

Meet the Expert: 《Asian Journal of Andrology》2025年第2期F0002-F0002,共1页; Kamil Gill,PhD,Kamil Gill is a biologist who graduated from the University of Szczecin(Poland)with a Master degree.Dr.Gill earned his scientific degree from the Pomeranian Medical University in Szczecin(PUM).His docto...; 关键词：human sperm chromatin assisted reproduction conditions embryo development ZYGOTE male infertility assisted reproduction human sperm chromatin parameters molecular markers

The role of SRPK1-mediated phosphorylation of SR proteins in the chromatin configuration transition of mouse germinal vesicle oocytes: 《Journal of Biomedical Research》2025年第2期198-208,I0013-I0015,共14页Xia Wang Shuai Zhou Haojie Yin Jian Han Yue Hu Siqi Wang Congjing Wang Jie Huang Junqiang Zhang Xiufeng Ling Ran Huo; National Natural Science Foundation of China(Grant Nos.32070838 and 82301874);Open Fund of State Key Laboratory of Reproductive Medicine,Nanjing Medical University(Grant No.SKLRM K202102)。; Meiotic resumption in mammalian oocytes involves nuclear and organelle structural changes,notably the chromatin configuration transition from a non-surrounding nucleolus(NSN)to surrounding nucleolus(SN)in germinal ves...; 关键词：OOCYTE CHROMATIN nuclear speckle SR protein PHOSPHORYLATION SRPK1

SETD3-mediated histidine methylation of MCM7 regulates DNA replication by facilitating chromatin loading of MCM: 《Science China(Life Sciences)》2025年第3期793-808,共16页Hongguo Duan Shuang Wang Wen-Jie Shu Yongjia Tong Hai-Zhen Long Guohong Li Hai-Ning Du Meng-Jie Zhao; supported by the National Key Research and Development program of China(2023YF0913403);the National Natural Science Foundation of China(32200584,31971231);the Fundamental Research Funds for the Central Universities(2042022dx0003,2042022kf1048);the China Postdoctoral Science Foundation(2021M702526).; The minichromosome maintenance complex(MCM)DNA helicase is an important replicative factor during DNA replication.The proper chromatin loading of MCM is a key step to ensure replication initiation during S phase.Becau...; 关键词：histidine methylation SETD3 DNA replication MCM replication origin firing

TRIM66-HP1γremodels the chromatin through phase separation: 《Biophysics Reports》2025年第1期18-33,共16页Siyuan Shen Feng Chen Yifan Zhang Fudong Li Xuebiao Yao Dan Liu Yunyu Shi Liang Zhang; supported by the National Natural Science Foundation of China(32090040,32293213,92149302 and 32470817);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB37010105 and XDB39010300);the Fundamental Research Funds for the Central Universities(WK9100000067)。; Chromatin contains not only heterochromatin(HC)and euchromatins(EC)but also facultative heterochromatin(f HC),which experience the dynamic remodeling between HCs and ECs by different regulators.The regulation of f HCs...; 关键词：CHROMATIN TRIM66-HP1γ Facultative heterochromatin Phase separation

Cryopreservation of bovine sperm causes single‑strand DNA breaks that are localized in the toroidal regions of chromatin: 《Journal of Animal Science and Biotechnology》2025年第1期92-106,共15页Jordi Ribas‑Maynou Rodrigo Muiño Carolina Tamargo Marc Yeste; Ministry of Science,Innovation and Universities,Spain(NextGeneration EU funds;María Zambrano Program 124/MTAI/22;and PID2020-113320RB-I00);Agency for Management of University and Research Grants,Regional Government of Catalonia,Spain(2021-SGR-00900);Catalan Institution for Research and Advanced Studies(ICREA).; Background Sperm cryopreservation is widely used in the cattle industry,as it allows for disassociating the localiza-tion of sires and the collection of semen from the timing of artificial insemination.While freeze-th...; 关键词：Cattle DNA damage Fertility Sperm Toroid linker regions

Chromatin accessibility: biological functions, molecular mechanisms and therapeutic application: 《Signal Transduction and Targeted Therapy》2025年第1期60-98,共39页Yang Chen Rui Liang Yong Li Lingli Jiang Di Ma Qing Luo Guanbin Song; supported by the National Natural Science Foundation of China(No.82203598);Natural Science Foundation of Chongqing(No.cstc2021jcyj-msxmX0536).; The dynamic regulation of chromatin accessibility is one of the prominent characteristics of eukaryotic genome. The inaccessible regions are mainly located in heterochromatin, which is multilevel compressed and access...; 关键词：MECHANISMS FUNCTIONS LANDSCAPE

PDLIM1 sustains DNA damage response by promoting chromatin relaxation and activating DNA-PK complex: 《Genes & Diseases》2024年第6期24-27,共4页Yue Lang Dexuan Gao Lan Yu Xiang-Xiang Zhang Debabrata Saha Benjamin P.C.Chen Meng-Meng Gu Zeng-Fu Shang; funded by grants from the National Natural Science Foundation of China (No.82003226 and 81972964);the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD);the Natural Science Foundation of Shandong Province (ZR2021MH085).; PDZ and LIM domain protein 1(PDLIM1)is a cytoplasmic LIM protein that regulates cytoskeleton organization and functions as a platform to coordinate various cellular processes.1 Accumulated evidence suggests that PDLIM...; 关键词：INVASION inhibited DAMAGE

Unveiling structural and dynamical features of chromatin using NMR spectroscopy This article is part of the virtual special issue“Solid-state NMR studies on polymers and biological solids”: 《Magnetic Resonance Letters》2024年第4期62-70,共9页Xiangyan Shi; supported by funds from the National Natural Science Foundation of China(grant number:32201006);Guangdong Province(grant number:2021QN02Y103,2022ZDZX2061,2022KCXTD034);2023 Stable Support Plan Program of Shenzhen Colleges and Universities Fund.; Eukaryotic deoxyribonucleic acid(DNA)is wrapped around histone octamers(HOs)to form nucleosome core particles(NCPs),which in turn interact with linker DNA and linker histones to assemble chromatin fibers with more com...; 关键词：CHROMATIN Structure Dynamics Phase separation Solution-state NMR Solid-state NMR

Integrative analysis of transcriptome,DNA methylome,and chromatin accessibility reveals candidate therapeutic targets in hypertrophic cardiomyopathy: 《Protein & Cell》2024年第11期796-817,共22页Junpeng Gao Mengya Liu Minjie Lu Yuxuan Zheng Yan Wang Jingwei Yang Xiaohui Xue Yun Liu Fuchou Tang Shuiyun Wang Lei Song Lu Wen Jizheng Wang; supported by the National Natural Science Foundation of China(Grant No.82170290);the CAMS Innovation Fund for Medical Sciences(Grant No.2023-I2M-1-001);Project funded by China Postdoctoral Science Foundation(Grant No.2023M732704);the Open Research Fund of the National Center for Protein Sciences at Peking University in Beijing.; Hypertrophic cardiomyopathy(HCM)is the most common inherited heart disease and is characterized by primary left ventricular hypertrophy usually caused by mutations in sarcomere genes.The mechanism underlying cardiac r...; 关键词：hypertrophic cardiomyopathy multi-omics chromatin accessibility DNA methylation fetal gene reprogramming therapy

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