PHOSPHORYLATION

作品数：608被引量：2178H指数：20
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相关领域：医药卫生生物学更多>>
相关作者：王勇博程涵薛宇李丰朱戈更多>>
相关机构：华中科技大学中国科学技术大学中国医科大学中国科学院更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金广东省自然科学基金更多>>
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The CK1-Opaque2 module orchestrates endosperm filling and nutrient storage in maize seeds
《The Crop Journal》2025年第1期192-203,共12页Longyu Liao Yunqin Huang Shanshan Wang Haoyu Zhang Jingying Pan Zhenglan Long Yongcai Huang Xiaoling Li Di Chen Tao Yang 
supported by Biological Breeding-National Science and Technology Major Project(2023ZD04069);Young Scientist Project(2023YFD1200008);the National Natural Science Foundation of China(32472122);Sichuan Provincial General Project(24NSFSC1704);the Open Project Program and Biological Breeding Program of State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China(SKL-ZY202211).
Phosphorylation is one of the major posttranslational modifications to control plant growth and development.Opaque2(O2)represents a central hub for endosperm filling,which largely determines seed yield and nutrient st...
关键词：MAIZE ENDOSPERM PHOSPHORYLATION Opaque2 CK1 
Phosphorylation modification reverses the transcriptional inhibitory activity of CsMYB4a in tea plants(Camellia sinensis)
《Horticultural Plant Journal》2025年第1期406-416,共11页Guoliang Ma Yunyun Han Tongtong Li Tao Xia Liping Gao 
supported by the joint funds of National Natural Science Foundation of China(Grant Nos.U21A20232,32372756,32072621)。
The members of the fourth subgroup of R2R3-MYB(Sg4 members)are well-known inhibitors of phenylpropanoid and lignin synthesis pathways.The C2 domain is closely related to the transcriptional inhibitory activity of Sg4 ...
关键词：Camellia sinensis Cs MYB4a Phenylpropanoid pathway MAPK YABBY Leaf development 
CBL1/CIPK23 phosphorylates tonoplast sugar transporter TST2 to enhance sugar accumulation in sweet orange(Citrus sinensis)
《Journal of Integrative Plant Biology》2025年第2期327-344,共18页Mengdi Li Zuolin Mao Zeqi Zhao Siyang Gao Yanrou Luo Ziyan Liu Xiawei Sheng Xiawan Zhai Ji-Hong Liu Chunlong Li 
supported by National Key Research and Development Program of China(2023YFD2300603,2022YFF1003100);the National Natural Science Foundation of China(32322073);Foundation of Hubei Hongshan Laboratory(2021hszd016);Fundamental Research Funds for the Central Universities(2662023PY011);the Huazhong Agricultural University(start-up funding to C.L.)。
Fruit taste quality is greatly influenced by the content of soluble sugars,which are predominantly stored in the vacuolar lumen.However,the accumulation and regulation mechanisms of sugars in most fruits remain unclea...
关键词：CITRUS CsCBL1/CIPK23 PHOSPHORYLATION tonoplast sugar transporter VACUOLE 
Improving regulatory T cell-based therapy:insights into post-translational modification regulation
《Journal of Genetics and Genomics》2025年第2期145-156,共12页Aiting Wang Yanwen Wang Rui Liang Bin Li Fan Pan 
supported by grants from the National Key R&D Program of China(2022YFC2403000 and 2021YFC2400500);the National Natural Science Foundation of China(32200728 and 32170925);the Clinical Research Project of Shenzhen Medical Academy of Research and Translation(C2301008);Shenzhen Science and Technology Program(JCYJ20220531100406014,JCYJ2022081800807016,RCBS20221008093336088,KQTD20210811090115019);Guangdong Basic and Applied Basic Research Foundation(2021A1515110375);the Innovative Research Team of High-level Local Universities in Shanghai(SHSMU-ZDCX20210601).
Regulatory T(Treg)cells are pivotal for maintaining immune homeostasis and play essential roles in various diseases,such as autoimmune diseases,graft-versus-host disease(GVHD),tumors,and infectious diseases.Treg cells...
关键词：Treg cell FOXP3 UBIQUITINATION ACETYLATION PHOSPHORYLATION METHYLATION GLYCOSYLATION Post-translational modification 
Ex vivo STAT3 phosphorylation in circulating immune cells:a novel biomarker for early cancer diagnosis and response to anti-PD-1 therapy
《Cancer Communications》2025年第1期58-62,共5页Sung-Woo Lee Young Ju Kim Saei Jeong Kyung Na Rho Jeong Eun Noh Hee-Ok Kim Hyun-Ju Cho Yoo Duk Choi Deok Hwan Yang Eu Chang Hwang Woo Kyun Bae Sook Jung Yun Ju Sik Yun Cheol-Kyu Park In-Jae Oh Jae-Ho Cho 
funded by National Research Foundation of Korea(2020R1A5A2031185,2020M3A9G3080281,2022R1A2C2009385,2020M3A9G3080330,and 2022R1A6A3A01086438).
Basal signal transducer and activator of transcription 3(STAT3)activation is well-documented in the tumor microenvironment(TME)due to its association with cancer prognosis[1].However,its presence and clinical relevanc...
关键词：STAT3 VIVO DIAGNOSIS 
PTPN9 regulates HER3 phosphorylation during trastuzumab treatment and loss of PTPN9 is a potential biomarker for trastuzumab resistance in HER2 positive breast cancer
《Cancer Communications》2025年第1期68-73,共6页Abul Azad Maryam Arshad Daniele Generali Katharina Feldinger Merel Gijsen Carla Strina Mariarosa Cappelletti Daniele Andreis Russell Leek Syed Haider Pirkko-Liisa Kellokumpu-Lehtinen Ioannis Roxanis Adrian Llewellyn Harris Abeer Mahmoud Shaaban Heikki Joensuu Anthony Kong 
supported by Breakthrough Breast cancer(Grant number:CSFKong)through Holbeck Charitable Trust;Prof A Shaaban is supported by Birmingham CRUK Centre grant.
Although trastuzumab does not bind to human epidermal growth factor receptor 3(HER3),it dephosphorylates HER3 through a previously unknownmechanism.In addition,HER3 is reactivated during prolonged trastuzumab treatmen...
关键词：HER3 TRASTUZUMAB TREATMENT HER2 PTP 
Correlations of the expression of Cx43,SCF^(FBXW7),p-cyclin E1(Ser73),p-cyclin E1(Thr77)and p-cyclin E1(Thr395)in colon cancer tissues
《World Journal of Gastrointestinal Oncology》2025年第1期207-213,共7页Rong-Gang Luan Ming-Da Liu Zi-Feng Deng Cong-Lan Lu Mei-Ling Yu Ming-Yu Zhang Rong Liu Ran An You-Liang Yao Dong-Bei Guo Yong-Xing Zhang Lei Zhao 
Supported by Innovative Practice Platform for Undergraduate Students,School of Public Health Xiamen University,No.2021001.
BACKGROUND Previous cellular studies have demonstrated that elevated expression of Cx43 promotes the degradation of cyclin E1 and inhibits cell proliferation through ubiquitination.Conversely,reduced expression result...
关键词：Colon cancer CX43 SCF^(FBXW7) Phosphorylation of cyclin E1 Sites of cyclin E1 Correlation analysis 
Phosphorylation determines the glucose metabolism reprogramming and tumor-promoting activity of sine oculis homeobox 1
《Signal Transduction and Targeted Therapy》2025年第1期240-255,共16页Yanni Lin Ling Li Bin Yuan Fei Luo Xiujuan Zhang Yuanjun Yang Shaliu Luo Jing Lin Tianxing Ye Youzhi Zhang Shan Gao Qinong Ye 
supported by the National Natural Science Foundation of China(81930078 and 82330083 to Q.Y.and 81902838 to L.L.);the National Key Research and Development Program of China(2022YFA1104003 to Q.Y.);Natural Science Foundation of Beijing(7204284 to L.L.);Basic and Clinical Collaborative Research Enhanced Program of Anhui Medical University(2021xkjT025 to B.Y.);the Doctoral Start-up Foundation of Anhui Medical University(0110050201 to B.Y.).
Aerobic glycolysis is a hallmark of cancer and is regulated by growth factors,protein kinases and transcription factors.However,it remains poorly understood how these components interact to regulate aerobic glycolysis...
关键词：metabolism programming SINE 
Decoding post-translational modification for understanding stress tolerance in plant
《Crop Design》2024年第4期9-20,共12页Anuradha Pandey Dipak Gayen 
DG is gratefully acknowledging the SERB-DST grant(SRG/2020/001024),(CRG/2023/003167);Central University of Rajasthan research support;AP is gratefully acknowledging the Central University of Rajasthan for financial support。
Plants undergo deteriorating stress situations,which has an adverse effect on their overall growth,maturation,and development.To mitigate these situations plants undergo regulatory cellular mechanisms including epigen...
关键词：Post-translational modification PHOSPHORYLATION UBIQUITINATION SUMOYLATION GLYCOSYLATION Biotic Abiotic stress Dehydration stress Salt stress Cold stress 
Effects of simulated gas of thermobaric bomb charge explosion on Tau protein phosphorylation and cognitive function in rats
《China Medical Abstracts(Internal Medicine)》2024年第4期201-202,共2页LI Liang 
Objective To explore the effect of simulated gas of thermobaric bomb charge explosion on cognitive function and the related mechanism of damage.Methods In January 2022,thirty-two SPF rats were selected and randomly di...
关键词：RATS CHARGE function 
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