PHOSPHORYLATION

作品数：616被引量：2190H指数：20
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相关领域：医药卫生生物学更多>>
相关作者：王勇博程涵薛宇李丰朱戈更多>>
相关机构：华中科技大学中国科学技术大学中国医科大学中国科学院更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金广东省自然科学基金更多>>
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Phosphorylation-related genes in lupus nephritis:Single-cell and machine learning insights
《Genes & Diseases》2025年第3期31-34,共4页Lisha Mou Zhihao Chen Xinran Tian Yupeng Lai Zuhui Pu Meiying Wang 
supported by the Science and Technology Program for Basic Research in Shenzhen,Guangdong,China(No.JCYJ20200109140412476,JCYJ20190809095811254,GCZX2015043017281705);the Clinical Research Project in Shenzhen,Guangdong,China(No.20213357002,20213357028);the Team-based Medical Science Research Program in Shenzhen,Guangdong,China(No.2024YZZ06);Shenzhen High-level Hospital Construction Fund in Shenzhen,Guangdong,China(No.2024).
This study investigates key genes contributing to lupus nephritis(LN).While extensive research has elucidated various aspects of LN pathogenesis,the specific involvement of phosphorylation-related genes(PRGs)in this c...
关键词：nonnegative matrix factorization nmf algorithmwe machine learning renal tissues lupus nephritis critical gene patterns single cell RNA sequencing lupus nephritis ln phosphorylation related genes 
Picropodophyllotoxin: A Natural Epimer Targeting STAT3 Phosphorylation and ROS-Mediated Apoptosis in Oral Squamous Cell Carcinoma Cells
《BIOCELL》2025年第4期647-663,共17页Jung-ⅡChae Ji-Hye Seo Goo Yoon Young-Joo Jeon Woo-Keun Kim 
supported by the Korea Institute of Toxicology(KIT)Research Program[No.2710008763(KK-2401-01)];the Korea Environmental Industry&Technology Institute(KEITI)through the Core Technology Development Project for Environmental Diseases Prevention and Management[No.2480000072(RS-2021-KE001705)]。
Background:Picropodophllotoxin(PPT),a principal component of Podophyllum hexandrum root,demonstrates various beneficial biological activities in multiple cancer types,including antitumor and antiproliferative properti...
关键词：Picropodophyllotoxin STAT3 ROS oral squamous cell carcinoma APOPTOSIS 
The OsSAPK10-OsPAL1 module contributes to rice blast resistance
《The Crop Journal》2025年第2期385-394,共10页Zhijuan Diao Houli Zhou Xun Wang Bangsheng Wang Ling Lu Na Xia Fanyu Kong Kexin Ji Sirui Xie Shengping Li Dingzhong Tang 
supported by National Key Research and Development Program of China(2023YFF1000500);the National Natural Science Foundation of China(32161133012).
The SnRK2 gene family plays important roles in ABA mediated abiotic stress responses.However,the roles and functional mechanism of the SnRK2 gene family in plant immunity are largely unknown.In this study,we report th...
关键词：OsSAPK10 OsPAL1 Rice blast resistance PHOSPHORYLATION SnRK2 
The role of SRPK1-mediated phosphorylation of SR proteins in the chromatin configuration transition of mouse germinal vesicle oocytes
《Journal of Biomedical Research》2025年第2期198-208,I0013-I0015,共14页Xia Wang Shuai Zhou Haojie Yin Jian Han Yue Hu Siqi Wang Congjing Wang Jie Huang Junqiang Zhang Xiufeng Ling Ran Huo 
National Natural Science Foundation of China(Grant Nos.32070838 and 82301874);Open Fund of State Key Laboratory of Reproductive Medicine,Nanjing Medical University(Grant No.SKLRM K202102)。
Meiotic resumption in mammalian oocytes involves nuclear and organelle structural changes,notably the chromatin configuration transition from a non-surrounding nucleolus(NSN)to surrounding nucleolus(SN)in germinal ves...
关键词：OOCYTE CHROMATIN nuclear speckle SR protein PHOSPHORYLATION SRPK1 
The CK1-Opaque2 module orchestrates endosperm filling and nutrient storage in maize seeds
《The Crop Journal》2025年第1期192-203,共12页Longyu Liao Yunqin Huang Shanshan Wang Haoyu Zhang Jingying Pan Zhenglan Long Yongcai Huang Xiaoling Li Di Chen Tao Yang 
supported by Biological Breeding-National Science and Technology Major Project(2023ZD04069);Young Scientist Project(2023YFD1200008);the National Natural Science Foundation of China(32472122);Sichuan Provincial General Project(24NSFSC1704);the Open Project Program and Biological Breeding Program of State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China(SKL-ZY202211).
Phosphorylation is one of the major posttranslational modifications to control plant growth and development.Opaque2(O2)represents a central hub for endosperm filling,which largely determines seed yield and nutrient st...
关键词：MAIZE ENDOSPERM PHOSPHORYLATION Opaque2 CK1 
Phosphorylation modification reverses the transcriptional inhibitory activity of CsMYB4a in tea plants(Camellia sinensis)
《Horticultural Plant Journal》2025年第1期406-416,共11页Guoliang Ma Yunyun Han Tongtong Li Tao Xia Liping Gao 
supported by the joint funds of National Natural Science Foundation of China(Grant Nos.U21A20232,32372756,32072621)。
The members of the fourth subgroup of R2R3-MYB(Sg4 members)are well-known inhibitors of phenylpropanoid and lignin synthesis pathways.The C2 domain is closely related to the transcriptional inhibitory activity of Sg4 ...
关键词：Camellia sinensis Cs MYB4a Phenylpropanoid pathway MAPK YABBY Leaf development 
CBL1/CIPK23 phosphorylates tonoplast sugar transporter TST2 to enhance sugar accumulation in sweet orange(Citrus sinensis)
《Journal of Integrative Plant Biology》2025年第2期327-344,共18页Mengdi Li Zuolin Mao Zeqi Zhao Siyang Gao Yanrou Luo Ziyan Liu Xiawei Sheng Xiawan Zhai Ji-Hong Liu Chunlong Li 
supported by National Key Research and Development Program of China(2023YFD2300603,2022YFF1003100);the National Natural Science Foundation of China(32322073);Foundation of Hubei Hongshan Laboratory(2021hszd016);Fundamental Research Funds for the Central Universities(2662023PY011);the Huazhong Agricultural University(start-up funding to C.L.)。
Fruit taste quality is greatly influenced by the content of soluble sugars,which are predominantly stored in the vacuolar lumen.However,the accumulation and regulation mechanisms of sugars in most fruits remain unclea...
关键词：CITRUS CsCBL1/CIPK23 PHOSPHORYLATION tonoplast sugar transporter VACUOLE 
Improving regulatory T cell-based therapy:insights into post-translational modification regulation
《Journal of Genetics and Genomics》2025年第2期145-156,共12页Aiting Wang Yanwen Wang Rui Liang Bin Li Fan Pan 
supported by grants from the National Key R&D Program of China(2022YFC2403000 and 2021YFC2400500);the National Natural Science Foundation of China(32200728 and 32170925);the Clinical Research Project of Shenzhen Medical Academy of Research and Translation(C2301008);Shenzhen Science and Technology Program(JCYJ20220531100406014,JCYJ2022081800807016,RCBS20221008093336088,KQTD20210811090115019);Guangdong Basic and Applied Basic Research Foundation(2021A1515110375);the Innovative Research Team of High-level Local Universities in Shanghai(SHSMU-ZDCX20210601).
Regulatory T(Treg)cells are pivotal for maintaining immune homeostasis and play essential roles in various diseases,such as autoimmune diseases,graft-versus-host disease(GVHD),tumors,and infectious diseases.Treg cells...
关键词：Treg cell FOXP3 UBIQUITINATION ACETYLATION PHOSPHORYLATION METHYLATION GLYCOSYLATION Post-translational modification 
Ex vivo STAT3 phosphorylation in circulating immune cells:a novel biomarker for early cancer diagnosis and response to anti-PD-1 therapy
《Cancer Communications》2025年第1期58-62,共5页Sung-Woo Lee Young Ju Kim Saei Jeong Kyung Na Rho Jeong Eun Noh Hee-Ok Kim Hyun-Ju Cho Yoo Duk Choi Deok Hwan Yang Eu Chang Hwang Woo Kyun Bae Sook Jung Yun Ju Sik Yun Cheol-Kyu Park In-Jae Oh Jae-Ho Cho 
funded by National Research Foundation of Korea(2020R1A5A2031185,2020M3A9G3080281,2022R1A2C2009385,2020M3A9G3080330,and 2022R1A6A3A01086438).
Basal signal transducer and activator of transcription 3(STAT3)activation is well-documented in the tumor microenvironment(TME)due to its association with cancer prognosis[1].However,its presence and clinical relevanc...
关键词：STAT3 VIVO DIAGNOSIS 
PTPN9 regulates HER3 phosphorylation during trastuzumab treatment and loss of PTPN9 is a potential biomarker for trastuzumab resistance in HER2 positive breast cancer
《Cancer Communications》2025年第1期68-73,共6页Abul Azad Maryam Arshad Daniele Generali Katharina Feldinger Merel Gijsen Carla Strina Mariarosa Cappelletti Daniele Andreis Russell Leek Syed Haider Pirkko-Liisa Kellokumpu-Lehtinen Ioannis Roxanis Adrian Llewellyn Harris Abeer Mahmoud Shaaban Heikki Joensuu Anthony Kong 
supported by Breakthrough Breast cancer(Grant number:CSFKong)through Holbeck Charitable Trust;Prof A Shaaban is supported by Birmingham CRUK Centre grant.
Although trastuzumab does not bind to human epidermal growth factor receptor 3(HER3),it dephosphorylates HER3 through a previously unknownmechanism.In addition,HER3 is reactivated during prolonged trastuzumab treatmen...
关键词：HER3 TRASTUZUMAB TREATMENT HER2 PTP 
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