supported by Breakthrough Breast cancer(Grant number:CSFKong)through Holbeck Charitable Trust;Prof A Shaaban is supported by Birmingham CRUK Centre grant.
Although trastuzumab does not bind to human epidermal growth factor receptor 3(HER3),it dephosphorylates HER3 through a previously unknownmechanism.In addition,HER3 is reactivated during prolonged trastuzumab treatmen...