GLYCOSYLATION

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Improving regulatory T cell-based therapy:insights into post-translational modification regulation
《Journal of Genetics and Genomics》2025年第2期145-156,共12页Aiting Wang Yanwen Wang Rui Liang Bin Li Fan Pan 
supported by grants from the National Key R&D Program of China(2022YFC2403000 and 2021YFC2400500);the National Natural Science Foundation of China(32200728 and 32170925);the Clinical Research Project of Shenzhen Medical Academy of Research and Translation(C2301008);Shenzhen Science and Technology Program(JCYJ20220531100406014,JCYJ2022081800807016,RCBS20221008093336088,KQTD20210811090115019);Guangdong Basic and Applied Basic Research Foundation(2021A1515110375);the Innovative Research Team of High-level Local Universities in Shanghai(SHSMU-ZDCX20210601).
Regulatory T(Treg)cells are pivotal for maintaining immune homeostasis and play essential roles in various diseases,such as autoimmune diseases,graft-versus-host disease(GVHD),tumors,and infectious diseases.Treg cells...
关键词：Treg cell FOXP3 UBIQUITINATION ACETYLATION PHOSPHORYLATION METHYLATION GLYCOSYLATION Post-translational modification 
Photolabile ortho-Nitro-Benzyl Carbonate as a Permanent Hydroxyl Protecting Group for the Synthesis of Digalactosyl Diacylglycerol
《Chinese Journal of Chemistry》2025年第2期169-174,共6页Jibin Zheng Hongyu Chen Jintao Shang Lvfeng Zhang Youling Liang Dongsheng Chang You Yang 
support from the National Natural Science Foundation of China(22071054,21871081);the Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism(Shanghai Municipal Education Commission);the Taishan IndustrialExperts Program(tscx202312168))is ggratefully acknowledged.
Traditional protecting groups are often removed under harsh conditions with potentially hazardous reagents,thereby impeding the convenient synthesis of oligosaccharides and glycosides.Herein,we present to utilize the ...
关键词：Carbohydrates Protecting groups GLYCOSYLATION GLYCOLIPIDS GLYCOSIDES Photocatalysis Gold catalysis Synthetic methods 
Decoding post-translational modification for understanding stress tolerance in plant
《Crop Design》2024年第4期9-20,共12页Anuradha Pandey Dipak Gayen 
DG is gratefully acknowledging the SERB-DST grant(SRG/2020/001024),(CRG/2023/003167);Central University of Rajasthan research support;AP is gratefully acknowledging the Central University of Rajasthan for financial support。
Plants undergo deteriorating stress situations,which has an adverse effect on their overall growth,maturation,and development.To mitigate these situations plants undergo regulatory cellular mechanisms including epigen...
关键词：Post-translational modification PHOSPHORYLATION UBIQUITINATION SUMOYLATION GLYCOSYLATION Biotic Abiotic stress Dehydration stress Salt stress Cold stress 
Digitoxose as powerful glycosyls for building multifarious glycoconjugates of natural products and un-natural products
《Synthetic and Systems Biotechnology》2024年第4期701-712,共12页Kemeng Li Zhengyan Guo Liping Bai 
supported by grants from National Key Research and Development Program of China(2018YFA0902000);National Natural Science Foundation of China(82173721);CAMS Innovation Fund for Medical Sciences(CIFMS,2021-I2M-1-029).
Digitoxose,a significant 2,6-dideoxyhexose found in nature,exists in many small-molecule natural products.These digitoxose-containing natural products can be divided into steroids,macrolides,macrolactams,anthracycline...
关键词：Digitoxose BIOSYNTHESIS Small-molecule natural products Digitoxose glycosylation 
Synthetic Investigation toward Acyl Group-Free Escin Derivatives
《Chinese Journal of Chemistry》2024年第24期3263-3268,共6页Xin Lv Jin-Xi Liao Zhen-Qiang Li Zhi-Sheng Xiong Qi-Shuang Yin Hui Liu Yuan-Hong Tu Jian-Song Sun 
supported by the National Natural Science Foundation of China(22177042 and 22307048);The generous support from Beijing Municipal Commission of Science and Technology(L212015)was also highly appreciated.
With protoescigenin as starting material and through orchestrated application of Yu and Schmidt glycosylation protocols,the synthesis of acyl group-free escin derivatives was achieved for the first time.As the undesir...
关键词：ESCIN Triterpenoid saponin Synthesis Yu glycosylation Schmidt glycosylation Carbohydrates Gold Hydrogen bonds 
Altered glycosylation in cancer: molecular functions and therapeutic potential
《Cancer Communications》2024年第11期1316-1336,共21页Xuemeng Xu Qiu Peng Xianjie Jiang Shiming Tan Wenjuan Yang Yaqian Han Linda Oyang Jinguan Lin Mengzhou Shen Jiewen Wang Haofan LiLongzheng Xia Mingjing Peng Nayiyuan Wu Yanyan Tang Hui Wang Qianjin Liao Yujuan Zhou 
supported in part by grants from the following sources:the National Natural Science Foundation of China(82472882,82302987,82303534,82203233,82202966,82173142);the Natural Science Foundation of Hunan Province(2024JJ4025,2023ZJ1122,Z2023086,2023JJ60469,2023JJ40413,2023JJ30372,2023JJ30375,2022JJ80078,2020JJ5336);Key Research and Development Program of Hunan Province(2022SK2051);Science and Technology Innovation Program of Hunan Province(2023RC3199,2023SK4034,2023RC1073);the Research Project of Health Commission of Hunan Province(R2023040,R2023093,202203034978,202202055318,202109031837,202109032010,20201020);the Changsha Science and Technology Board(kh2201054);Ascend Foundation of National cancer center(NCC201909B06);by Hunan Cancer Hospital Climb Plan(ZX2020001-3,YF2020002,2023NSFC-A001,2023NSFC-A002,2023NSFC-A004).
Glycosylation,a key mode of protein modification in living organisms,is critical in regulating various biological functions by influencing protein folding,transportation,and localization.Changes in glycosylation patte...
关键词：GLYCOSYLATION IMMUNITY cellular senescence tumor biomarkers cancer therapy 
“Small is beautiful”-Examining reliable determination of low-abundant therapeutic antibody glycovariants
《Journal of Pharmaceutical Analysis》2024年第10期1435-1449,共15页Katharina Böttinger Christof Regl Veronika Schäpertöns Erdmann Rapp Therese Wohlschlager Christian G.Huber 
Glycans associated with biopharmaceutical drugs play crucial roles in drug safety and efficacy,and therefore,their reliable detection and quantification is essential.Our study introduces a multi-level quantification a...
关键词：GLYCOSYLATION Mass spectrometry Monoclonal antibodies Abundance profiling Minor glycovariants Multi-level analysis Data integration 
Expeditious chemical synthesis of xylomannans disproves the proposed antifreeze activities被引量：1
《National Science Review》2024年第10期291-299,共9页Qian Zhu Simone Nicolardi Yuanguang Wang Yasong Liu Peng Xu Jianjun Wang Dapeng Zhu Biao Yu 
supported by the National Key Research&Development Program of China(2022YFA1304700 and 2023YFA1508800);the National Natural Science Foundation of China(22031011 and 92253301);the Key Research Program of Frontier Sciences of CAS(ZDBS-LY-SLH030);the CAS Project for Young Scientists in Basic Research(YSBR-095);Shanghai Municipal Science and Technology Major Project,and Shanghai Jiao Tong University STAR program(20230102).
Cold-adapted species are able to generate cryoprotective proteins and glycoproteins to prevent freezing damage.The[→4)-β-D-Man p-(1→4)-β-D-Xyl p-(1→]_(n)xylomannan from the Alaska beetle Upis ceramboides was disc...
关键词：xylomannan GLYCOSYLATION POLYSACCHARIDE total synthesis ANTIFREEZE 
Chemoenzymatic Synthesis of N,N,N-Trimethyl-D-Glucosamine Chitotriomycin and Its Analogues
《Chinese Journal of Chemistry》2024年第19期2293-2298,共6页Jianghua Li Yan Zhang Zhifei Hu Jinfeng Ye Hongzhi Cao 
supported by the National Key Research and Development Program of China(2021YFC2101500);the National Natural Science Foundation of China(22277111 and 22107094);Taishan Scholar Project(TSTP20221114);Department of Science and Technology of Shandong Province(2020CXGC010601,ZR2023ZD45,and ZR2021QB061).
Comprehensive Summary,N,N,N-Trimethyl-D-glucosamine(TMG)-chitotriomycin,a naturally occurring chitin related oligosaccharide,is a specificβ-N-acetylhexosaminidases(HexNAcases)inhibitor for insects and fungi.Although ...
关键词：Carbohydrates GLYCOSYLATION Chitosan OLIGOSACCHARIDES BIOCATALYSIS 
GP-Plotter:Flexible Spectral Visualization for Proteomics Data with Emphasis on Glycoproteomics Analysis
《Genomics, Proteomics & Bioinformatics》2024年第5期167-173,共7页Zheng Fang Mingming Dong Hongqiang Qin Mingliang Ye 
supported in part by funds from the National Key R&D Program of China(Grant Nos.2022YFC3400801 and 2021YFA1302601);the National Natural Science Foundation of China(Grant Nos.22034007,22274014,92153302,22304174);the innovation program of science and research from the Dalian Institute of Chemical Physics(DICP);Chinese Academy of Sciences(CAS)(Grant No.DMU-2&DICP UN202303);the Youth Innovation Promotion Association of CAS(Grant No.Y2022059);the China Postdoctoral Science Foundation(Grant No.2023M743424).
Identification evaluation and result dissemination are essential components in mass spectrometry-based proteomics analysis.The visualization of fragment ions in mass spectrum provides strong evidence for peptide ident...
关键词：GLYCOPROTEOMICS GLYCOSYLATION PROTEOMICS Software VISUALIZATION 
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