GP-Plotter:Flexible Spectral Visualization for Proteomics Data with Emphasis on Glycoproteomics Analysis  

作　　者：Zheng Fang Mingming Dong Hongqiang Qin Mingliang Ye 

机构地区：[1]State Key Laboratory of Medical Proteomics,National Chromatographic R.&A.Center,CAS Key Laboratory of Separation Science for Analytical Chemistry,Dalian Institute of Chemical Physics,Chinese Academy of Sciences,Dalian 116023,China [2]School of Bioengineering,Dalian University of Technology,Dalian 116024,China [3]University of Chinese Academy of Sciences,Beijing 100049,China

出　　处：《Genomics, Proteomics & Bioinformatics》2024年第5期167-173,共7页基因组蛋白质组与生物信息学报(英文版)

基　　金：supported in part by funds from the National Key R&D Program of China(Grant Nos.2022YFC3400801 and 2021YFA1302601);the National Natural Science Foundation of China(Grant Nos.22034007,22274014,92153302,22304174);the innovation program of science and research from the Dalian Institute of Chemical Physics(DICP);Chinese Academy of Sciences(CAS)(Grant No.DMU-2&DICP UN202303);the Youth Innovation Promotion Association of CAS(Grant No.Y2022059);the China Postdoctoral Science Foundation(Grant No.2023M743424).

摘　　要：Identification evaluation and result dissemination are essential components in mass spectrometry-based proteomics analysis.The visualization of fragment ions in mass spectrum provides strong evidence for peptide identification and modification localization.Here,we present an easy-to-use tool,named GP-Plotter,for ion annotation of tandem mass spectra and corresponding image output.Identification result files of common searching tools in the community and user-customized files are supported as input of GP-Plotter.Multiple display modes and parameter customization can be achieved in GP-Plotter to present annotated spectra of interest.Different image formats,especially vector graphic formats,are available for image generation which is favorable for data publication.Notably,GP-Plotter is also well-suited for the visualization and evaluation of glycopeptide spectrum assignments with comprehensive annotation of glycan fragment ions.With a user-friendly graphical interface,GP-Plotter is expected to be a universal visualization tool for the community.GP-Plotter has been implemented in the latest version of Glyco-Decipher(v1.0.4)and the standalone GP-Plotter software is also freely available at https://github.com/DICP-1809.

关 键 词：GLYCOPROTEOMICS GLYCOSYLATION PROTEOMICS Software VISUALIZATION 

分 类 号：Q811.4[生物学—生物工程]