GLYCOPROTEOMICS

作品数:13被引量:18H指数:2
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相关领域:医药卫生生物学更多>>
相关机构:中国科学院上海高等研究院更多>>
相关期刊:《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》《Asian Pacific Journal of Tropical Medicine》《Science China(Life Sciences)》《World Journal of Gastroenterology》更多>>
相关基金:国家自然科学基金国家重点基础研究发展计划上海市浦江人才计划项目国家高技术研究发展计划更多>>
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Rapid and large-scale glycopeptide enrichment strategy based on chemical ligation
《National Science Review》2024年第11期142-153,共12页Yingying Xiong Zhuoer Lu Yuyin Shao Peiyi Meng Guoli Wang Xinwen Zhou Jun Yao Huimin Bao Haojie Lu 
supported by the National Key Research and Development Program of China(2023YFF1205900);the National Natural Science Foundation of China(22434001 and 82121004);the Shanghai Science and Technology Program(2023SHZDZX02,22DZ2291700 and 22142202400).
Protein glycosylation,the most universal post-translational modification,is thought to play a crucial role in regulating multiple essential cellular processes.However,the low abundance of glycoproteins and the heterog...
关键词:GLYCOPROTEOMICS large-scale enrichment O-GLCNACYLATION N-GLYCOSYLATION oxidative stress 
GP-Plotter:Flexible Spectral Visualization for Proteomics Data with Emphasis on Glycoproteomics Analysis
《Genomics, Proteomics & Bioinformatics》2024年第5期167-173,共7页Zheng Fang Mingming Dong Hongqiang Qin Mingliang Ye 
supported in part by funds from the National Key R&D Program of China(Grant Nos.2022YFC3400801 and 2021YFA1302601);the National Natural Science Foundation of China(Grant Nos.22034007,22274014,92153302,22304174);the innovation program of science and research from the Dalian Institute of Chemical Physics(DICP);Chinese Academy of Sciences(CAS)(Grant No.DMU-2&DICP UN202303);the Youth Innovation Promotion Association of CAS(Grant No.Y2022059);the China Postdoctoral Science Foundation(Grant No.2023M743424).
Identification evaluation and result dissemination are essential components in mass spectrometry-based proteomics analysis.The visualization of fragment ions in mass spectrum provides strong evidence for peptide ident...
关键词:GLYCOPROTEOMICS GLYCOSYLATION PROTEOMICS Software VISUALIZATION 
Mass spectrometry-based structure-specific N-glycoproteomics and biomedical applications被引量:1
《Acta Biochimica et Biophysica Sinica》2024年第8期1172-1183,共12页Ming Bi Zhixin Tian 
supported by the grants from the National Natural Science Foundation of China(Nos.22074105 and 21775110);the Shanghai Science and Technology Commission(No.14DZ2261100).
N-linked glycosylation is a common posttranslational modification of proteins that results in macroheterogeneity of the modification site.However,unlike simpler modifications,N-glycosylation introduces an additional l...
关键词:N-GLYCOSYLATION N-glycoproteomics mass spectrometry structure specific biomedical application 
Mass spectrometry analysis of intact protein N-glycosylation signatures of cells and sera in pancreatic adenocarcinomas
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2024年第1期51-64,共14页Mingming XU Zhaoliang LIU Wenhua HU Ying HAN Zhen WU Sufeng CHEN Peng XIA Jing DU Xumin ZHANG Piliang HAO Jun XIA Shuang YANG 
approved by the Research Ethics Committees of Zhejiang Provincial People’s Hospital(No.QT2022387).
Pancreatic cancer is among the most malignant cancers,and thus early intervention is the key to better survival outcomes.However,no methods have been derived that can reliably identify early precursors of development ...
关键词:Pancreatic cancer GLYCOSYLATION Biomarker GLYCOPROTEOMICS Mass spectrometry 
High-throughput site-specific N-glycoproteomics reveals glyco-signatures for liver disease diagnosis被引量:2
《National Science Review》2023年第1期209-220,共12页Zhenyu Sun Bin Fu Guoli Wang Lei Zhang Ruofan Xu Ying Zhang Haojie Lu 
the National Key Research and Development Program of China(2020YFE0202200);the National Natural Science Foundation of China(22174021,21974025and 82121004);the project of Shanghai Key Laboratory of Kidney and Blood Purification;Shanghai Pujiang Program(2019PJD003);the Innovative Research Team of High-Level Local University in Shanghai。
The glycoproteome has emerged as a prominent target for screening biomarkers,as altered glycosylation is a hallmark of cancer cells.In this work,we incorporated tandem mass tag labeling into quantitative glycoproteomi...
关键词:GLYCOPROTEOMICS HIGH-THROUGHPUT quantification N-glycopeptides liver disease 
Identifying intact N-glycopeptides from tandem mass spectrometry data using StrucGP
《Biophysics Reports》2022年第5期282-300,共19页Jiechen Shen Zexuan Chen Shisheng Sun 
supported by the National Key Research and Development Program of China(2019YFA09005200);the National Natural Science Foundation of China(91853123,81773180)
Protein glycosylation is of great importance in many biological processes. Glycosylation has been increasingly analyzed at the intact glycopeptide level using mass spectrometry to study site-specific glycosylation cha...
关键词:Protein glycosylation GLYCOPROTEOMICS Mass spectrometry StrucGP Glycan structure 
N-Glycoproteomics Study of Putative N-Glycoprotein Biomarkers of Drug Resistance in MCF-7/ADR Cells被引量:2
《Phenomics》2021年第6期269-284,共16页Hailun Yang Feifei Xu Kaijie Xiao Yun Chen Zhixin Tian 
supported by National Natural Science Foundation of China(21775110,22074105);Shanghai Science and Technology Commission(14DZ2261100).
Currently,drug resistance of anti-cancer therapy has become the main cause of low survival rate and poor prognosis.Full understanding of drug resistance mechanisms is an urgent request for further development of anti-...
关键词:MCF-7/ADR cells MCF-7 cells Drug resistance Differential N-glycosylation N-glycoproteomics 
Mass Spectrometry-based Proteomics and Glycoproteomics in COVID-19 Biomarkers Identification:A Mini-review被引量:2
《Journal of Analysis and Testing》2021年第4期298-313,共16页Li Zhong Lin Zhu Zong-Wei Cai 
funded by SZSTC(SGDX20190816230207535);obtained a donation from Kwok Chung Bo Fun Charitable Fund,which commemorates the establishment of the Kwok Yat Wai Endowed Chair of Environmental and Biological Analysis。
The first corona-pandemic,coronavirus disease 2019(COVID-19)caused a huge health crisis and incalculable damage worldwide.Knowledge of how to cure the disease is urgently needed.Emerging immune escaping mutants of the...
关键词:COVID-19 SARS-CoV-2 BIOMARKER PROTEOMICS GLYCOPROTEOMICS 
Glycoproteomics analysis of plasma proteins associated with Opisthorchis viverrini infection-induced cholangiocarcinoma in hamster model被引量:1
《Asian Pacific Journal of Tropical Medicine》2016年第12期1142-1147,共6页Pramote Sriwanitchrak Atchara Paemanee Sittiruk Roytrakul Vithoon Viyanant Kesara Na-Bangchang 
supported by the National Research University Project(NRU)of Thailand Office of Higher Education Commission,Ministry of Education of Thailand and Thammasat University(Excellence Center in Pharmacology and Molecular Biology of Malaria and Cholangiocarcinoma)
Objective: To apply lectin affinity chromatography and glycoproteomics-based LC-MS/MS to preliminarily investigate the possible potential plasma biomarkers of Opisthorchis viverrini(OV)-associated CCA in OV/dimethylni...
关键词:CHOLANGIOCARCINOMA Opisthorchis viverrini GLYCOPROTEIN Hamster model ConA binding protein LC-MS/MS 
Glycoproteins and glycoproteomics in pancreatic cancer被引量:4
《World Journal of Gastroenterology》2016年第42期9288-9299,共12页Sheng Pan Teresa A Brentnall Ru Chen 
Aberrations in protein glycosylation and polysaccharides play a pivotal role in pancreatic tumorigenesis, influencing cancer progression, metastasis, immunoresponse and chemoresistance. Abnormal expression in sugar mo...
关键词:GLYCOPROTEINS GLYCOSYLATION PROTEOMICS GLYCOPROTEOMICS Pancreatic cancer Pancreatic ductal adenocarcinoma 
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