supported by the National Key Research and Development Program of China(2023YFF1205900);the National Natural Science Foundation of China(22434001 and 82121004);the Shanghai Science and Technology Program(2023SHZDZX02,22DZ2291700 and 22142202400).
Protein glycosylation,the most universal post-translational modification,is thought to play a crucial role in regulating multiple essential cellular processes.However,the low abundance of glycoproteins and the heterog...
supported in part by funds from the National Key R&D Program of China(Grant Nos.2022YFC3400801 and 2021YFA1302601);the National Natural Science Foundation of China(Grant Nos.22034007,22274014,92153302,22304174);the innovation program of science and research from the Dalian Institute of Chemical Physics(DICP);Chinese Academy of Sciences(CAS)(Grant No.DMU-2&DICP UN202303);the Youth Innovation Promotion Association of CAS(Grant No.Y2022059);the China Postdoctoral Science Foundation(Grant No.2023M743424).
Identification evaluation and result dissemination are essential components in mass spectrometry-based proteomics analysis.The visualization of fragment ions in mass spectrum provides strong evidence for peptide ident...
supported by the grants from the National Natural Science Foundation of China(Nos.22074105 and 21775110);the Shanghai Science and Technology Commission(No.14DZ2261100).
N-linked glycosylation is a common posttranslational modification of proteins that results in macroheterogeneity of the modification site.However,unlike simpler modifications,N-glycosylation introduces an additional l...
approved by the Research Ethics Committees of Zhejiang Provincial People’s Hospital(No.QT2022387).
Pancreatic cancer is among the most malignant cancers,and thus early intervention is the key to better survival outcomes.However,no methods have been derived that can reliably identify early precursors of development ...
the National Key Research and Development Program of China(2020YFE0202200);the National Natural Science Foundation of China(22174021,21974025and 82121004);the project of Shanghai Key Laboratory of Kidney and Blood Purification;Shanghai Pujiang Program(2019PJD003);the Innovative Research Team of High-Level Local University in Shanghai。
The glycoproteome has emerged as a prominent target for screening biomarkers,as altered glycosylation is a hallmark of cancer cells.In this work,we incorporated tandem mass tag labeling into quantitative glycoproteomi...
supported by the National Key Research and Development Program of China(2019YFA09005200);the National Natural Science Foundation of China(91853123,81773180)
Protein glycosylation is of great importance in many biological processes. Glycosylation has been increasingly analyzed at the intact glycopeptide level using mass spectrometry to study site-specific glycosylation cha...
supported by National Natural Science Foundation of China(21775110,22074105);Shanghai Science and Technology Commission(14DZ2261100).
Currently,drug resistance of anti-cancer therapy has become the main cause of low survival rate and poor prognosis.Full understanding of drug resistance mechanisms is an urgent request for further development of anti-...
funded by SZSTC(SGDX20190816230207535);obtained a donation from Kwok Chung Bo Fun Charitable Fund,which commemorates the establishment of the Kwok Yat Wai Endowed Chair of Environmental and Biological Analysis。
The first corona-pandemic,coronavirus disease 2019(COVID-19)caused a huge health crisis and incalculable damage worldwide.Knowledge of how to cure the disease is urgently needed.Emerging immune escaping mutants of the...
supported by the National Research University Project(NRU)of Thailand Office of Higher Education Commission,Ministry of Education of Thailand and Thammasat University(Excellence Center in Pharmacology and Molecular Biology of Malaria and Cholangiocarcinoma)
Objective: To apply lectin affinity chromatography and glycoproteomics-based LC-MS/MS to preliminarily investigate the possible potential plasma biomarkers of Opisthorchis viverrini(OV)-associated CCA in OV/dimethylni...
Aberrations in protein glycosylation and polysaccharides play a pivotal role in pancreatic tumorigenesis, influencing cancer progression, metastasis, immunoresponse and chemoresistance. Abnormal expression in sugar mo...