N-GLYCOSYLATION

作品数：36被引量：21H指数：2
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STT3-mediated aberrant N-glycosylation of CD24 inhibits paclitaxel sensitivity in triple-negative breast cancer
《Acta Pharmacologica Sinica》2025年第4期1097-1110,共14页Jun Wang Hui-min Zhang Guan-hua Zhu Li-li Zhao Ji Shi Zhou-tong Dai Jia-peng Li Xing-rui Li Fan Sun Yuan Wu Shao-yong Chen Han-ning Li Xing-hua Liao Yuan Xiang 
financially supported by the National Natural Science Foundation of China(32170578 and 82203497);Hubei Natural Science Foundation(2024AFB905 and 2024AFD011);Hubei Province Key R&D Program(2022BCA007);Department of Education Scientific Research Program guidance project(B2023014);“The 14th Five Year Plan”Hubei Provincial advantaged characteristic disciplines(groups)project of Wuhan University of Science and Technology(2023C0303);Natural Science Foundation Exploration Program of Wuhan(2024040801020310);the Hunan Natural Science Foundation(2023JJ50310 and 2023JJ50296).
Paclitaxel is one of the main chemotherapic medicines against triple-negative breast cancer(TNBC)in clinic.However,it has been perplexed by paclitaxel resistance in TNBC patients,resulting in a poor prognosis.Abnormal...
关键词：triple-negative breast cancer PACLITAXEL CD24 N-GLYCOSYLATION ferroptosis STT3 
Stabilization of EREG via STT3B-mediated N-glycosylation is critical for PDL1 upregulation and immune evasion in head and neck squamous cell carcinoma
《International Journal of Oral Science》2024年第4期728-742,共15页Shengming Xu Haifeng Wang Yu Zhu Yong Han Liu Liu Xiangkai Zhang Jingzhou Hu Wuchang Zhang Shengzhong Duan Jiong Deng Zhiyuan Zhang Shuli Liu 
supported by the Fundamental Research program funding of Ninth People’s Hospital affiliated to Shanghai Jiao Tong University School of Medicine(JYZZ233);the National Nature Science Foundation of China(grant numbers81802696,82172565);The CAMS Innovation Fund for Medical Sciences(CIFMS)(Project No.2019-I2M-5-037);Shanghai Clinical Research Center for Oral Diseases(19MC1910600)。
Dysregulated Epiregulin(EREG)can activate epidermal growth factor receptor(EGFR)and promote tumor progression in head and neck squamous cell carcinoma(HNSCC).However,the mechanisms underlying EREG dysregulation remain...
关键词：PDL1 SQUAMOUS inhibited 
Rapid and large-scale glycopeptide enrichment strategy based on chemical ligation
《National Science Review》2024年第11期142-153,共12页Yingying Xiong Zhuoer Lu Yuyin Shao Peiyi Meng Guoli Wang Xinwen Zhou Jun Yao Huimin Bao Haojie Lu 
supported by the National Key Research and Development Program of China(2023YFF1205900);the National Natural Science Foundation of China(22434001 and 82121004);the Shanghai Science and Technology Program(2023SHZDZX02,22DZ2291700 and 22142202400).
Protein glycosylation,the most universal post-translational modification,is thought to play a crucial role in regulating multiple essential cellular processes.However,the low abundance of glycoproteins and the heterog...
关键词：GLYCOPROTEOMICS large-scale enrichment O-GLCNACYLATION N-GLYCOSYLATION oxidative stress 
Mass spectrometry-based structure-specific N-glycoproteomics and biomedical applications被引量：1
《Acta Biochimica et Biophysica Sinica》2024年第8期1172-1183,共12页Ming Bi Zhixin Tian 
supported by the grants from the National Natural Science Foundation of China(Nos.22074105 and 21775110);the Shanghai Science and Technology Commission(No.14DZ2261100).
N-linked glycosylation is a common posttranslational modification of proteins that results in macroheterogeneity of the modification site.However,unlike simpler modifications,N-glycosylation introduces an additional l...
关键词：N-GLYCOSYLATION N-glycoproteomics mass spectrometry structure specific biomedical application 
FUT8-mediated aberrant N-glycosylation of SEMA7A promotes head and neck squamous cell carcinoma progression被引量：2
《International Journal of Oral Science》2024年第2期333-348,共16页Zhonglong Liu Xiaoyan Meng Yuxin Zhang Jingjing Sun Xiao Tang Zhiyuan Zhang Liu Liu Yue He 
supported by the National Natural Science Foundation of China(NSFC:82173451);Project of Biobank(YBKB202105)from Shanghai Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai Municipal Health Commission(No.2022LJ001);the Natural Science Foundation of Shanghai(22ZR1437600);Shanghai’s Top Priority Research Center(2022ZZ01017).
SEMA7A belongs to the Semaphorin family and is involved in the oncogenesis and tumor progression.Aberrant glycosylation has been intricately linked with immune escape and tumor growth.SEMA7A is a highly glycosylated p...
关键词：ABERRANT SQUAMOUS SEMA 
N-glycosylation of Wnt3 regulates the progression of hepatocellular carcinoma by affecting Wnt/β-catenin signal pathway
《World Journal of Gastrointestinal Oncology》2024年第6期2769-2780,共12页Xin-Zhan Zhang Xiao-Chuan Mo Zhu-Ting Wang Rong Sun Da-Quan Sun 
Supported by National Natural Science Foundation of China,No.81560390;the Guizhou Medical University Cultivation Project of the National Natural Science Foundation of China,No.22NSFCP02;Basic Research Project of Science and Technology Department of Guizhou Province,No.ZK[2024]General 136.
BACKGROUND Wnt/FZD-mediated signaling pathways are activated in more than 90%of hepatocellular carcinoma(HCC)cell lines.As a well-known secretory glycoprotein,Wnt3 can interact with FZD receptors on the cell surface,t...
关键词：Wnt3 N-GLYCOSYLATION Hepatocellular carcinoma Liver cancer WNT/Β-CATENIN FZD7 
The role of N-glycosylation in cancer被引量：4
《Acta Pharmaceutica Sinica B》2024年第3期1098-1110,共13页Yu Lin David M.Lubman 
support of this work from the National Cancer Institute under Grants 1R01 CA160254 and U01 CA225753(David M.Lubman,USA)。
Despite advances in understanding the development and progression of cancer in recent years,there remains a lack of comprehensive characterization of the cancer glycoproteome.Glycoproteins play an important role in me...
关键词：N-Glycosylated proteins Cancer signaling Cancer angiogenesis Cancer metabolism Cancer biomarkers 
转录因子HNF1A、HNF4A和FOXA2调节肝细胞蛋白质N-糖基化
《Engineering》2024年第1期57-68,共12页Vedrana Vicic Bockor Nika Foglar Goran Josipovic Marija Klasic Ana Vujic Branimir Plavsa Toma Keser Samira Smajlovic Aleksandar Vojta Vlatka Zoldos 
the European Structural and Investment Funded Grant"Cardio Metabolic"(#KK.01.2.1.02.0321);the Croatian National Centre of Research Excellence in Personalized Healthcare Grant(#KK.01.1.1.01.0010);the European Regional Development Fund Grant,project"CRISPR/Cas9-CasMouse"(#KK.01.1.1.04.0085);the European Structural and Investment Funded Project of Centre of Competence in Molecular Diagnostics(#KK.01.2.2.03.0006);the Croatian National Centre of Research Excellence in Personalized Healthcare Grant(#KK.01.1.1.01.0010).
Hepatocyte nuclear factor 1 alpha(HNF1A),hepatocyte nuclear factor 4 alpha(HNF4A),and forkhead box protein A2(FOXA2)are key transcription factors that regulate a complex gene network in the liver,cre-ating a regulator...
关键词：Clustered regularly interspaced short palindromic repeats/dead Cas9(CRISPR/dCas9) EPIGENETICS Hepatocyte nuclear factor 1 alpha(HNF1A) Hepatocyte nuclear factor 4 alpha(HNF4A) Forkhead box protein A2(FOXA2) N-GLYCOSYLATION HepG2 cells 
Mass spectrometry analysis of intact protein N-glycosylation signatures of cells and sera in pancreatic adenocarcinomas
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2024年第1期51-64,共14页Mingming XU Zhaoliang LIU Wenhua HU Ying HAN Zhen WU Sufeng CHEN Peng XIA Jing DU Xumin ZHANG Piliang HAO Jun XIA Shuang YANG 
approved by the Research Ethics Committees of Zhejiang Provincial People’s Hospital(No.QT2022387).
Pancreatic cancer is among the most malignant cancers,and thus early intervention is the key to better survival outcomes.However,no methods have been derived that can reliably identify early precursors of development ...
关键词：Pancreatic cancer GLYCOSYLATION Biomarker GLYCOPROTEOMICS Mass spectrometry 
Site-specific N-glycosylation characterization and allergenicity analysis of globulin-1 S allele from wheat
《Food Science and Human Wellness》2023年第5期1601-1608,共8页Linglin Fu Rongrong Wang Jinru Zhou Chong Wang Yanbo Wang 
financially supported by the National Natural Science Foundation of China (31871735)。
N-glycans in many proteins are of great concern because of their strong association with food allergies. Triticum aestivum(bread wheat), a major food crop, is known as one of the “Big Eight” allergenic groups. Howev...
关键词：Triticum aestivum ALLERGEN GLYCOPROTEIN N-GLYCANS N-GLYCOSYLATION C_(18)-RPLC-MS/MS 
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