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作品数：201被引量：605H指数：12
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相关领域：医药卫生更多>>
相关作者：杨音杨楠孙鸾张欣孙玉洁更多>>
相关机构：第二军医大学第三军医大学西南医院南京医科大学湖州市第三人民医院更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金广东省自然科学基金更多>>
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Glutamatergic CYLD deletion leads to aberrant excitatory activity in the basolateral amygdala:association with enhanced cued fear expression
《Neural Regeneration Research》2025年第11期3259-3272,共14页Huidong Li Faqin Li Zhaoyi Chen Erwen Wu Xiaoxi Dai Danni Li Haojie An Shiyi Zeng Chunyan Wang Li Yang Cheng Long 
supported by the National Natural Science Foundation of China,Nos.32371065(to CL)and 32170950(to LY);the Natural Science Foundation of the Guangdong Province,No.2023A1515010899(to CL);the Science and Technology Projects in Guangzhou,Nos.2023A4J0578 and 2024A03J0180(to CW)。
Neuronal activity,synaptic transmission,and molecular changes in the basolateral amygdala play critical roles in fear memory.Cylindromatosis(CYLD)is a deubiquitinase that negatively regulates the nuclear factor kappa-...
关键词：basolateral amygdala cued fear expression cylindromatosis deubiquitinase glutamate receptor 1 glutamatergic neuron microglial activation N-methyl-D-aspartate receptor 1 neuronal activation synaptic transmission 
Inflammatory transcriptomic signatures and cell type compositions in inflamed and non-inflamed colonic mucosa of ulcerative colitis Ulcerative colitis
《Genes & Diseases》2025年第3期72-75,共4页Eun Mi Song Jahanzeb Saqib Yang Hee Joo Zehra Ramsha Chang Mo Moon Sung-Ae Jung Junil Kim 
supported by the Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Education of the Republic of Korea(No.2020R1I1A1A01073545 to E.M.S.,2020R1A2C1010786 to C.M.M.,2021R1A6A1A10044154 to J.K).
Inflammatory transcriptomic signatures and cell type compositions in inflamed and non-inflamed colonic mucosa of ulcerative colitis Ulcerative colitis(UC),a subtype of inflammatory bowel disease,arises from disrupted ...
关键词：cell type compositions aberrant innate immune response intestinal microbiota colonic mucosa disrupted gut homeostasisprimarily healing mucosal inflammation ulcerative colitis uc ulcerative colitis 
STT3-mediated aberrant N-glycosylation of CD24 inhibits paclitaxel sensitivity in triple-negative breast cancer
《Acta Pharmacologica Sinica》2025年第4期1097-1110,共14页Jun Wang Hui-min Zhang Guan-hua Zhu Li-li Zhao Ji Shi Zhou-tong Dai Jia-peng Li Xing-rui Li Fan Sun Yuan Wu Shao-yong Chen Han-ning Li Xing-hua Liao Yuan Xiang 
financially supported by the National Natural Science Foundation of China(32170578 and 82203497);Hubei Natural Science Foundation(2024AFB905 and 2024AFD011);Hubei Province Key R&D Program(2022BCA007);Department of Education Scientific Research Program guidance project(B2023014);“The 14th Five Year Plan”Hubei Provincial advantaged characteristic disciplines(groups)project of Wuhan University of Science and Technology(2023C0303);Natural Science Foundation Exploration Program of Wuhan(2024040801020310);the Hunan Natural Science Foundation(2023JJ50310 and 2023JJ50296).
Paclitaxel is one of the main chemotherapic medicines against triple-negative breast cancer(TNBC)in clinic.However,it has been perplexed by paclitaxel resistance in TNBC patients,resulting in a poor prognosis.Abnormal...
关键词：triple-negative breast cancer PACLITAXEL CD24 N-GLYCOSYLATION ferroptosis STT3 
Mutations in GTPBP3 cause aberrant mitochondrial respiration associated with combined oxidative phosphorylation deficiency 23
《Genes & Diseases》2025年第1期76-79,共4页Qianqian Li Yang Yang Ranran Li Chenguang Yu Kaidi Ren Yin Feng Xing Chen Yi Luan Xiangdong Kong 
supported by the National Natural Science Foundation of China(No.82000321,31900502);Henan Educational Committee Program for Science and Technology Development of Universities(China)(No.22A310022,24A320017);Natural Science Foundation of Henan,China(No.212300410275);Henan Medical Science and Technology Joint Building Program(China)(No.LHGJ20190229,LHGJ20190236,and LHGJ20230283);the Medical Science and Technology Research Project of Henan Province(No.SBGJ202103079,SBGJ202302045).
Combined oxidative phosphorylation deficiency 23(COXPD23,MIM#616198)is a rare autosomal-recessive mitochondrial disorder with variable disease severity ranging from death in early infancy to survival into the second d...
关键词：OXIDATIVE clinical CARDIOMYOPATHY 
Aberrant network topological structure of sensorimotor superficial white-matter system in major depressive disorder
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2025年第1期39-51,共13页Peng WANG Yanling BAI Yang XIAO Yuhong ZHENG Li SUN The DIRECT Consortium Jinhui WANG Shaowei XUE 
supported by the Zhejiang Medical and Health Science and Technology Project(No.2022KY1055);the Zhejiang Provincial Natural Science Foundation of China(No.LY17H180007);the Key Clinical Specialty Construction Project of Zhejiang Province;the Key Medical Disciplines of Hangzhou,China.
White-matter tracts play a pivotal role in transmitting sensory and motor information,facilitating interhemispheric communication and integrating different brain regions.Meanwhile,sensorimotor disturbance is a common ...
关键词：Major depressive disorder(MDD) Magnetic resonance imaging(MRI) White matter Brain network 
Genome-wide DNA methylation and mRNA transcription analysis revealed aberrant gene regulation pathways in patients with dermatomyositis and polymyositis
《Chinese Medical Journal》2025年第1期120-122,共3页Hui Luo Honglin Zhu Ding Bao Yizhi Xiao Bin Zhou Gong Xiao Lihua Zhang Siming Gao Liya Li Yangtengyu Liu Di Liu Junjiao Wu Qiming Meng Meng Meng Tao Chen Xiaoxia Zuo Quanzhen Li Huali Zhang 
To the Editor:Idiopathic inflammatory myopathies(IIMs)are a diverse group of rare and refractory systemic autoimmune diseases.DNA methylation,influenced by both inherited DNA sequences and environmental exposure,is a ...
关键词：Idiopathic Inflammatory Myopathies inflammatory myopathies iims regulates gene expression epigenetic factor DNA Methylation DERMATOMYOSITIS POLYMYOSITIS 
Aberrant outputs of cerebellar nuclei and targeted rescue of social deficits in an autism mouse model
《Protein & Cell》2024年第12期872-888,共17页Xin-Yu Cai Xin-Tai Wang Jing-Wen Guo Fang-Xiao Xu Kuang-Yi Ma Zhao-Xiang Wang Yue Zhao Wei Xie Martijn Schonewille Chris De Zeeuw Wei Chen Ying Shen 
supported by grants from the STI2030-Major Projects (2021ZD0204000);Key Strategic Science and Technology Cooperation Project (2023YFE0206800) of the Ministry of Science and Technology of China;the National Natural Science Foundation of China (81625006, 31820103005, 32000692);Zhejiang Province Natural Science Foundation of China (LZ24C090003 and LY21C090003);the Science and Technology Programme of Hangzhou Municipaility (20190101A10);the Key Realm R&D Program of Guangdong Province (2019B030335001);the Netherlands Organization for Scientific Research (NWO-ALW 824.02.001);the Dutch Organization for Medical Sciences (Zon MW 91120067);Medical Neuro-Delta (MD 01092019-31082023);INTENSE LSH-NWO (TTW/00798883);ERC-adv (GA-294775);ERC-POC (737619 and 768914)
The cerebellum is heavily connected with other brain regions,sub-serving not only motor but also nonmotor functions.Genetic mutations leading to cerebellar dysfunction are associated with mental diseases,but cerebella...
关键词：CEREBELLUM THALAMUS MIDBRAIN large-scale tracing AUTISM 
Coal Worker’s Pneumoconiosis-Targeted Lipidomics Reveals Aberrant Phospholipid Metabolism for Early-Stage Diagnosis
《China CDC weekly》2024年第52期1410-1416,I0004,I0005,共9页Yuzhen Feng Jing Dai Junyun Wang Fangda Peng Wenrong Wang Xiao Yu Xiaomei Kong Qingjun Qian Qicai Liu Huanqiang Wang Chunguang Ding Yiwei Shi 
Introduction:Pneumoconiosis is the most prevalent occupational disease in China,with coal worker pneumoconiosis(CWP)demonstrating the highest incidence.Studies have indicated that phospholipids may be associated with ...
关键词：LIPID ELEVATED initially 
Exosomal miR-17-5p derived from epithelial cells is involved in aberrant epithelium-fibroblast crosstalk and induces the development of oral submucosal fibrosis
《International Journal of Oral Science》2024年第4期671-684,共14页Changqing Xie Liang Zhong Hui Feng Rifu Wang Yuxin Shi Yonglin Lv Yanjia Hu Jing Li Desheng Xiao Shuang Liu Qianming Chen Yongguang Tao 
supported by grants from the National Natural Science Foundation of China(82201079);the Natural Science Foundation of Hunan Province,China(2023JJ40881);the Major Project of Natural Science Foundation of Hunan Province(Open Competition,2021JC0002);the Fundamental Research Funds for the Central Universities of Central South University(2023ZZTS0582)。
Oral submucous fibrosis(OSF)is a chronic and inflammatory mucosal disease caused by betel quid chewing,which belongs to oral potentially malignant disorders.Abnormal fibroblast differentiation leading to disordered co...
关键词：EPITHELIUM metabolism diagnosis 
Aberrant dynamic functional connectivity of thalamocortical circuitry in major depressive disorder
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2024年第10期857-877,共21页Weihao ZHENG Qin ZHANG Ziyang ZHAO Pengfei ZHANG Leilei ZHAO Xiaomin WANG Songyu YANG Jing ZHANG Zhijun YAO Bin HU 
supported by the Science and Technology Innovation 2030-Major Projects(Nos.2021ZD0202000,2021ZD0200800,and 2021ZD0200701);the National Key Research and Development Program of China(No.2019YFA0706200);the National Natural Science Foundation of China(Nos.62227807,62202212,U21A20520,and U22A2033);the Science and Technology Program of Gansu Province(No.23YFGA0004),China.
Thalamocortical circuitry has a substantial impact on emotion and cognition.Previous studies have demonstrated alterations in thalamocortical functional connectivity(FC),characterized by region-dependent hypo-or hyper...
关键词：Major depressive disorder Resting-state functional magnetic resonance imaging Thalamocortical circuitry Dynamic functional connectivity Dynamic laterality 
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