MIDBRAIN

作品数：50被引量：105H指数：6
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相关作者：丁晔李良焦倩丁玉强张钱林更多>>
相关机构：首都医科大学第二军医大学北京师范大学河南省人民医院更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金湖北省自然科学基金更多>>
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Aberrant outputs of cerebellar nuclei and targeted rescue of social deficits in an autism mouse model
《Protein & Cell》2024年第12期872-888,共17页Xin-Yu Cai Xin-Tai Wang Jing-Wen Guo Fang-Xiao Xu Kuang-Yi Ma Zhao-Xiang Wang Yue Zhao Wei Xie Martijn Schonewille Chris De Zeeuw Wei Chen Ying Shen 
supported by grants from the STI2030-Major Projects (2021ZD0204000);Key Strategic Science and Technology Cooperation Project (2023YFE0206800) of the Ministry of Science and Technology of China;the National Natural Science Foundation of China (81625006, 31820103005, 32000692);Zhejiang Province Natural Science Foundation of China (LZ24C090003 and LY21C090003);the Science and Technology Programme of Hangzhou Municipaility (20190101A10);the Key Realm R&D Program of Guangdong Province (2019B030335001);the Netherlands Organization for Scientific Research (NWO-ALW 824.02.001);the Dutch Organization for Medical Sciences (Zon MW 91120067);Medical Neuro-Delta (MD 01092019-31082023);INTENSE LSH-NWO (TTW/00798883);ERC-adv (GA-294775);ERC-POC (737619 and 768914)
The cerebellum is heavily connected with other brain regions,sub-serving not only motor but also nonmotor functions.Genetic mutations leading to cerebellar dysfunction are associated with mental diseases,but cerebella...
关键词：CEREBELLUM THALAMUS MIDBRAIN large-scale tracing AUTISM 
Enhancement of endogenous midbrain neurogenesis by microneurotrophin BNN-20 after neural progenitor grafting in a mouse model of nigral degeneration
《Neural Regeneration Research》2024年第6期1318-1324,共7页Theodora Mourtzi Nasia Antoniou Christina Dimitriou Panagiotis Gkaravelas Georgia Athanasopoulou Panagiota Nti Kostantzo Olga Stathi Efthymia Theodorou Maria Anesti Rebecca Matsas Fevronia Angelatou Georgia Kouroupi Ilias Kazanis 
co-financed by Greece and the European Union(European Social Fund-ESF)through the Operational Programme《Human Resources Development,Education and Lifelong Learning 2014–2020》in the context of the project“NeuroProPar”(MIS 5047138,to IK)。
We have previously shown the neuroprotective and pro-neurogenic activity of microneurotrophin BNN-20 in the substantia nigra of the“weaver”mouse,a model of progressive nigrostriatal degeneration.Here,we extended our...
关键词：adult neurogenesis BNN-20 brain-derived neurotrophic factor cell replacement induced pluripotent stem cells(iPSCs) neurotrophic factors Parkinson's disease substantia 
Multiple factors to assist human-derived induced pluripotent stem cells to efficiently differentiate into midbrain dopaminergic neurons
《Neural Regeneration Research》2024年第4期908-914,共7页Yalan Chen Junxin Kuang Yimei Niu Hongyao Zhu Xiaoxia Chen Kwok-Fai So Anding Xu Lingling Shi 
supported by the National Natural Science Foundation of China,No.81771222(to LS);Guangzhou Key Research Program on Brain Science,Nos.202007030011,202206060001(to LS);the Program of Introducing Talents of Discipline to Universities of China,No.B14036(to KFS)。
Midbrain dopaminergic neurons play an important role in the etiology of neurodevelopmental and neurodegenerative diseases.They also represent a potential source of transplanted cells for therapeutic applications.In vi...
关键词：dopaminergic neurons FGF signal induced pluripotent stem cells MIDBRAIN neural differentiation SHH signal SMAD signal WNT signal 
Detection of a temporal salient object benefits from visual stimulus-specific adaptation in avian midbrain inhibitory nucleus
《Integrative Zoology》2024年第2期288-306,共19页Jiangtao WANG Xiaoping RAO Shuman HUANG Zhizhong WANG Xiaoke NIU Minjie ZHU Songwei WANG Li SHI 
supported by the National Natural Science Foundation of China(Grant No.62206253).
Food and predators are the most noteworthy objects for the basic survival of wild animals,and both are often deviant in both spatial and temporal domains and quickly attract an animal’s attention.Although stimulus-sp...
关键词：ADAPTATION attention model PIGEON SALIENCY 
Astrocytes contribute to toll-like receptor 2-mediated neurodegeneration and alpha-synuclein pathology in a human midbrain Parkinson’s model
《Translational Neurodegeneration》2024年第1期119-139,共21页Fiona Weiss Laura Hughes Yuhong Fu Cedric Bardy Glenda M.Halliday Nicolas Dzamko 
funded by a bequest from Francis Patrick Gill, the University of Sydney.F.W and L.H are funded by PhD scholarships from the University of Sydney.G.M.H.is a NHMRC Senior Leadership Fellow(#1176607).
Background Parkinson’s disease(PD)is characterised by degeneration of ventral midbrain dopaminergic(DA)neurons and abnormal deposition ofα-synuclein(α-syn)in neurons.Activation of the innate immune pathogen recogni...
关键词：Parkinson’s disease Toll-like receptor 2 ALPHA-SYNUCLEIN ASTROCYTE LYSOSOME 
An Anterior Cingulate Cortex-to-Midbrain Projection Controls Chronic Itch in
《Neuroscience Bulletin》2023年第5期793-807,共15页Ting-Ting Zhang Su-Shan Guo Hui-Ying Wang Qi Jing Xin Yi Zi-Han Hu Xin-Ren Yu Tian-Le Xu Ming-Gang Liu Xuan Zhao 
supported by grants from the National Natural Science Foundation of China(81873787,81961128024,32170994,and 82201362);Shanghai Natural Science Foundation(18ZR1424800 and 20ZR1430000);a Shanghai Municipal Science and Technology Major Project(2018SHZDZX05);the innovative research team of high-level local universities in Shanghai.
Itch is an unpleasant sensation that provokes the desire to scratch.While acute itch serves as a protec-tive system to warn the body of external irritating agents,chronic itch is a debilitating but poorly-treated clin...
关键词：sAnterior cingulate cortex Chronic itch Ventral tegmental area-Chemogenetics Neural circuit 
Enhanced replication of SARS-CoV-2 Omicron BA.2 in human forebrain and midbrain organoids被引量：2
《Signal Transduction and Targeted Therapy》2022年第12期4257-4260,共4页Yuxin Hou Chang Li Chaemin Yoon On Wah Leung Sikun You Xiaoming Cui Jasper Fuk-Woo Chan Duanqing Pei Hoi Hung Cheung Hin Chu 
Health and Medical Research Fund(CID-HKU1–5,COVID1903010–7 and-14,and 20190652);Food and Health Bureau,the Government of the Hong Kong Special Administrative Region,General Research Fund(14104321,14109920,14121618,14169717,17118621,and 17123920);Collaborative Research Fund(C7060-21GF);Theme-Based Research Scheme(T11-709/21-N),Research Grants Council,the Government of the Hong Kong Special Administrative Region;Health@InnoHK,Innovation and Technology Commission,the Government of the Hong Kong Special Administrative Region;National Natural Science Foundation of China Excellent Young Scientists Fund(Hong Kong and Macao)(32122001);the Consultancy Service for Enhancing Laboratory Surveillance of Emerging Infectious Diseases and Research Capability on Antimicrobial Resistance for Department of Health of the Hong Kong Special Administrative Region Government;Emergency Collaborative Project(EKPG22-01)of Guangzhou Laboratory;Emergency COVID-19 Project(2021YFC0866100),Major Projects on Public Security,National Key Research and Development Program;Sanming Project of Medicine in Shenzhen,China(SZSM201911014);the High Level-Hospital Program,Health Commission of Guangdong Province,China;the University of Hong Kong Outstanding Young Researcher Award;the University of Hong Kong Research Output Prize(Li Ka Shing Faculty of Medicine).
Dear Editor,Coronavirus Disease 2019(COVID-19)is associated with a variety of neurological complications,including encephalopathy,encephalitis,dementia,and others.1 The pathogenic mechanism of these neurological manif...
关键词：INVASION finding INCOMPLETE 
A Novel Movement Behavior Control Method for Carp Robot through the Stimulation of Medial Longitudinal Fasciculus Nucleus of Midbrain被引量：2
《Journal of Bionic Engineering》2022年第5期1302-1313,共12页Yang Zhao Yong Peng Yudong Wen Lingjun Han Hui Zhang Zheng Zhao Xiaoyue Liu 
This work was financially supported by the Project of National Natural Science Foundation of China(project number:61573305);Projectof Natural Science Foundation of Hebei Provinceof China(project number:F2019203511);National High-Tech Research and Development Plan of China(863 Plan)Project(2013AA***)Fund.
Biological robot is a kind of creature controlled by human beings by applying intervention signals through control technology to regulate biological behavior.At present,the research on bio-robot mainly focuses on terr...
关键词：Carp robot MIDBRAIN Medial longitudinal fasciculus nucleus Electrical stimulation Steering motion control Forward motion control 
Induced Dopaminergic Neurons for Parkinson's Disease Therapy: Targeting the Striatum or Midbrain/Substantia Nigra Pars Compacta?被引量：2
《Neuroscience Bulletin》2022年第7期820-824,共5页Huadong Xu Xu Cheng Qian Song Yuxin Yang Changhe Wang Xinjiang Kang 
This insight was,supported by,the National NaturalScienceFoundationofChina(32171233,32000704,81974203,81901308,31670843,21790390,and 21790394);the Natural Science Foundation of Sichuan Province,China(2020YJ0337 and 2020YJ0378);the Natural ScienceFoundation of Shaanxi Province of China(2020JQ-029 and 2019JC-07);the Key Research and Development Program of Shaanxi Province,China(2017SF-113);the Science and Technology Innovation Projects of China(20-163-00-TS-009-035-01);China Postdoctoral Science Foundation(2018M640972);the Innovation Capability Support Programof Shaanxi Province,China(2021TD-37).
Parkinson's disease(PD)is a common neurodegenerative disease among the elderly,characterized by the specific loss of dopaminergic(DAergic)neurons in the substantia nigra pars compacta(SNpc)and defects in dopamine(DA)r...
关键词：DOPAMINE THERAPY DOPAMINE 
A Deep Mesencephalic Nucleus Circuit Regulates Licking Behavior被引量：1
《Neuroscience Bulletin》2022年第6期565-575,共11页Di Zheng Jja-Yu Fu Meng-Yu Tang iao-Dan Yu Yi Zhu Chen Jie Shen Chun-Yue Li Shi-Ze Xiel Shan Lin Minmin Luo Xiao-Ming Li 
supported by the Key-Area Research and Development Program of Guangdong Province(2019B030335001 and 2018B030334001);the Natural Science Foundation of China(31871070 and 82090031);the Key R&D Program of Zhejiang Province(2020C03009);Funda-mental Research Funds for the Central Universities 2021FZZX001-37,the Non-Profit Central Research Institute Fund of the Chinese Academy of Medical Sciences(2019PT310023);and the CAMS Innovation Fund for Medical Sciences(2019-12M-5-057).
Licking behavior is important for water intake.The deep mesencephalic nucleus(DpMe)has been implicated in instinctive behaviors.However,whether the DpMe is involved in licking behavior and the precise neural circuit b...
关键词：MIDBRAIN AMYGDALA LICKING Neural Circuit OPTOGENETICS 
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