CEREBELLUM

作品数:109被引量:190H指数:7
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相关领域:医药卫生生物学更多>>
相关作者:沈颖陈浩胡波杨丽翁旭初更多>>
相关机构:西安交通大学医学院第一附属医院中南大学天津医科大学总医院中国科学技术大学更多>>
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相关基金:国家自然科学基金国家重点基础研究发展计划重庆市自然科学基金中国博士后科学基金更多>>
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Visualizing the distribution of mitochondrial molecular mRNAs of cerebellar Purkinje cells by RNAscope
《空军军医大学学报》2024年第12期1353-1369,共17页LIU Hui NI Ziwei LIU Yuxuan LI Shujiao WU Feifei WANG Lu YANG Yanling WANG Yayun 
Military Medical Advancement Program for Air Force Medical University(2020SWAQ04);Shaanxi Innovation Ability Support Plan(2023-CX-PT-33);Shaanxi Province Natural Science Basic Research Program(2024JC-ZDXM-60,2022JQ-820);New Clinical Technology of Xijing Hospital(2023XJSY27);National Natural Science Foundation of China(82201627)。
Objective To investigate the distribution of mitochondria-associated molecule mRNA in cerebellar Purkinje cells.Methods Transgenic technology was used to prepare Pcp2-tdTomato mouse labeled Purkinje cells.The mRNAs of...
关键词:mitochondrial dynamics proteins RNAscope Purkinje cell CEREBELLUM 
Aberrant outputs of cerebellar nuclei and targeted rescue of social deficits in an autism mouse model
《Protein & Cell》2024年第12期872-888,共17页Xin-Yu Cai Xin-Tai Wang Jing-Wen Guo Fang-Xiao Xu Kuang-Yi Ma Zhao-Xiang Wang Yue Zhao Wei Xie Martijn Schonewille Chris De Zeeuw Wei Chen Ying Shen 
supported by grants from the STI2030-Major Projects (2021ZD0204000);Key Strategic Science and Technology Cooperation Project (2023YFE0206800) of the Ministry of Science and Technology of China;the National Natural Science Foundation of China (81625006, 31820103005, 32000692);Zhejiang Province Natural Science Foundation of China (LZ24C090003 and LY21C090003);the Science and Technology Programme of Hangzhou Municipaility (20190101A10);the Key Realm R&D Program of Guangdong Province (2019B030335001);the Netherlands Organization for Scientific Research (NWO-ALW 824.02.001);the Dutch Organization for Medical Sciences (Zon MW 91120067);Medical Neuro-Delta (MD 01092019-31082023);INTENSE LSH-NWO (TTW/00798883);ERC-adv (GA-294775);ERC-POC (737619 and 768914)
The cerebellum is heavily connected with other brain regions,sub-serving not only motor but also nonmotor functions.Genetic mutations leading to cerebellar dysfunction are associated with mental diseases,but cerebella...
关键词:CEREBELLUM THALAMUS MIDBRAIN large-scale tracing AUTISM 
Cerebellar involvement in Parkinson's disease: Pathophysiology and neuroimaging
《Chinese Medical Journal》2024年第20期2395-2403,共9页Tao Qiu Meichen Liu Xinhui Qiu Tianbai Li Weidong Le 
supported by grants from the National Natural Science Foundation of China to WL(Nos.32220103006,and 82271524);the Liaoning Provincial Natural Science Foundation Joint Fund toTL(No.2023-MSLH-029);Shanghai Pudong New Area Health Commission Clinical Characteristic Discipline Construction Plan to TL(No.PWYts2021-02).
Parkinson's disease(PD)is a neurodegenerative disease characterized by various motor and non-motor symptoms.The com-plexity of its symptoms suggests that PD is a heterogeneous neurological disorder Its pathological ch...
关键词:Parkinson's disease CEREBELLUM NEUROIMAGING PATHOPHYSIOLOGY Differential diagnosis Disease progression 
Perspectives in the investigation of Cockayne syndrome group B neurological disease:the utility of patient-derived brain organoid models
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2024年第10期878-889,共12页Xintai WANG Rui ZHENG Marina DUKHINOVA Luxi WANG Ying SHEN Zhijie LIN 
supported by the National Natural Science Foundation of China(Nos.32000692 and 32200816).
Cockayne syndrome(CS)group B(CSB),which results from mutations in the excision repair cross-complementation group 6(ERCC6)genes,which produce CSB protein,is an autosomal recessive disease characterized by multiple pro...
关键词:Cockayne syndrome Cockayne syndrome group B(CSB) Neurological function CEREBELLUM ORGANOIDS 
The Cerebellum Modulates Mood with Movement
《Neuroscience Bulletin》2024年第9期1396-1398,共3页Shaofei Jiang Haitao Wu 
National Science Fund for Distinguished Young Scholars(32325025);National Natural Science Foundation of China(32171148 and 31770929).
Anxiety disorder stands as the most prevalent emotional disorder on a global scale[1].Traditional pharmacological interventions for anxiety disorder frequently encounter obstacles such as drug resistance and adverse r...
关键词:CLINICAL PRECISE SPITE 
Tetrabromobisphenol A exerts thyroid disrupting effects but has little overt impact on postnatal brain development and neurobehaviors in mice
《Journal of Environmental Sciences》2024年第8期1-10,共10页Shilin Song Yuanyuan Li Lin Lv Mengqi Dong Zhanfen Qin 
supported by the National Key Research and Development Program of China(No.2018YFA0901103);the National Natural Science Foundation of China(No.21876196)。
Tetrabromobisphenol A(TBBPA)is a widely used brominated flame retardant.There is evidence showing that TBBPA can exert thyroid disrupting effects in mammals,but different results were also reported,along with inconsis...
关键词:Tetrabromobisphenol A Thyroid disruption Brain development NEUROBEHAVIOR CEREBELLUM 
Probiotic microorganisms affect the reproductive and nervous systems of male rats treated with acrylamide
《Asian pacific Journal of Reproduction》2024年第4期178-186,共9页Seyedhossein Hekmatimoghaddam Maryam Yadegari Fateme Zare Fatemeh Zakizadeh Seyed Mohammad Seifati 
Shahid Sadoughi University of Medical Sciences,Yazd,Iran(grant number 5689).
Objective:To evaluate the protective effects of probiotic microorganisms on the reproductive and nervous systems of male rats treated with acrylamide.Methods:Thirty-two rats were randomly divided into 4 groups and rec...
关键词:ACRYLAMIDE CEREBELLUM MICROORGANISMS PROBIOTICS Prostate Rats TESTIS 
Distinct and Additive Effects of Alcohol and Thiamine Deficiency in the Developing Brain: Relevance to Fetal Alcohol Spectrum Disorder
《Journal of Behavioral and Brain Science》2024年第6期161-186,共26页Suzanne M. de la Monte Elizabeth Silbermann Ming Tong 
Background: Neurodevelopmental abnormalities in fetal alcohol spectrum disorder (FASD) are linked to brain insulin resistance and oxidative stress. However, the role of thiamine deficiency as a distinct or additive fa...
关键词:Fetal Alcohol Spectrum Disorder Thiamine Deficiency CEREBELLUM Slice Culture PYRITHIAMINE 
Bilateral effect of acupuncture on cerebrum and cerebellum in ischaemic stroke patients with hemiparesis:a randomised clinical and neuroimaging trial
《Stroke & Vascular Neurology》2024年第3期306-317,I0264-I0273,共22页Tianzhu Chen Tianyan Chen Yong Zhang Kang Wu Yihuai Zou 
funded by the National Natural Science Foundation of China(Grant No.82174331,Grant No.81873257);the Beijing Municipal Natural Science Foundation(Grant No.7182104).
Background Acupuncture involving the limb region may be effective for stroke rehabilitation clinically,but the visualised and explanatory evidence is limited.Our objectives were to assess the specific effects of acupu...
关键词:ACUPUNCTURE ACUPUNCTURE random 
Exploring cerebral structural and functional abnormalities in a mouse model of post-traumatic headache induced by mild traumatic brain injury被引量:1
《Zoological Research》2024年第3期648-662,共15页Dan Yang Bin-Bin Nie Jin-Gang He Zong-Qiang Lv Feng-Feng Mo Si-Yi Ouyang Jie Wang Ju-Xiang Chen Tao Tao 
supported by the Natural Science Foundation of Guangdong Province,China(2021A1515010897);Discipline Construction Fund of Central People’s Hospital of Zhanjiang(2020A01,2020A02);National Natural Science Foundation of China(31970973,21921004,32271148);Biosecurity Research Project(23SWAQ24)。
Mild traumatic brain injury(mTBI)-induced post-traumatic headache(PTH)is a pressing public health concern and leading cause of disability worldwide.Although PTH is often accompanied by neurological disorders,the exact...
关键词:Post-traumatic headache(PTH) Mild traumatic brain injury(mTBI) Metabolic kinetics FMRI CEREBELLUM 
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