ORGANOIDS

作品数：226被引量：458H指数：10
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Generation,interrogation,and future applications of microglia-containing brain organoids
《Neural Regeneration Research》2025年第12期3448-3460,共13页Julia Di Stefano Federica Di Marco Ilaria Cicalini Una FitzGerald Damiana Pieragostino Marleen Verhoye Peter Ponsaerts Elise Van Breedam 
funded by the European Union’s Horizon 2020 research and innovation programme under the Marie Skodowska-Curie grant agreement No.813263(PMSMat Train,granted to UF,PP,MV,and DP);provided by the Fund for Scientific Research Flanders(FWO-Vlaanderen)of the Flemish Government(FWO sabbatical bench fee K800224N granted to PP)and ERA-NET Re Park(granted to PP)。
Brain organoids encompass a large collection of in vitro stem cell–derived 3D culture systems that aim to recapitulate multiple aspects of in vivo brain development and function.First,this review provides a brief int...
关键词：3D cell culture brain organoids immune response immunocompetent model in vitro model MICROGLIA neural organoids NEUROIMMUNOLOGY neuroinflammation 
Spatiotemporal Observation of Monosodium Urate Crystals Deposition in Synovial Organoids Using Label-Free Stimulated Raman Scattering
《Research》2025年第1期246-256,共11页Yaxin Chen Ziyi Chen Wenjuan Wang Yinghui Hua Minbiao Ji 
supported by the National Key R&D Program of China(grant numbers 2021YFF0502900 and SQ 2020YFA0803800);the National Natural Science Foundation of China(grant number 82072510);the Shanghai Science and Technology Committee(grant numbers 22dz1204702 and 23dz2260100)。
Gout,a common form of arthritis,is characterized by the deposition of monosodium urate(MSU)crystals in joints.MSU deposition in synovial tissues would initiate arthritis flares and recurrence,causing irreversible join...
关键词：Monosodium urate crystals arthritis flares Stimulated Raman scattering microscopy Spatiotemporal observation Synovial organoids Fibroblast synoviocytes synovial tissues Inflammatory reactions 
Identification of AAV serotypes for gene therapy in Krabbe iPSCs-derived brain organoids
《Genes & Diseases》2025年第1期144-147,共4页Yafeng Lv Zhi Cui Hongbo Li Jing Wang Mulan Wei Yuanlang Hu Xun Li Chunyu Cao Ye Zhang Wei Wang 
funded by grants from the Beijing Municipal Science&TechnologyCommission(China)(No.Z211100002921005 to W.W.);National High-Level Hospital Clinical Research Funding(China)(No.2022-NHLHCRF-PY-12 to W.W.);Hubei Provincial Department of Education's Scientific and Technological Research Project(China)(No.Q20211207 to Y.L.);Yichang Medical and Health Science and Technology Project(Hubei,China)(No.A22-2-069 to Y.L.);the Open Foundation of Hubei Province Key Laboratory of Tumor Microenvironment and Immunotherapy(China)(No.2023KZL08 to Y.L.).
Krabbe disease,also known as globoid cell leukodystrophy,is a rare lysosomal storage disorder.It is primarily caused by mutations in the GALC gene on chromosome 14q31,leading to GALC enzyme deficiency in lysosomes.Thi...
关键词：AAV DYSTROPHY diseases 
3D bioprinted advanced cartilage organoids with engineered magnetic nanoparticles polarized-BMSCs/alginate/gelatin for cartilage tissue regeneration
《Nano Research》2025年第2期541-556,共16页Zhiyu Ding Junjie Huang Yijun Ren Ning Tang Xin Luo Huancheng Zhu Xu Cao Ming Zhao Song Wu 
This work was financially supported by Science and Technology Innovation Leading Plan of High-Tech Industry in Hunan Province(No.2020SK2011);The National Natural Science Foundation of China-Youth Science Fund(No.82204538);Macao Special Administrative Region Science and Technology Development Fund(No.0007/2021/AKP).
Cartilage defects are commonly observed in orthopedic clinical studies.Owing to the unique structure of cartilage tissue,current clinical treatments cannot fully address this issue.Cartilage organoids are three-dimens...
关键词：magnetic nanoparticles cell polarization three-dimensional(3D)bioprinting cartilage organoid cartilage repair 
Research Advances in the Construction and Application of Intestinal Organoids
《Biomedical and Environmental Sciences》2025年第2期230-247,共18页Qingxue Meng Hongyang Yi Peng Wang Shan Liu Weiquan Liang Cuishan Chi Chenyu Mao Weizheng Liang Jun Xue Hongzhou Lu 
funded by the National Natural Science Foundation of China(No.32300659);Shenzhen Science and Technology Innovation Commission Project(No.JCYJ20230807143302004);Zhangjiakou City Key R&D Plan Project(No.2421118D),Zhangjiakou City Key R&D Plan Project(No.2322088D);The Natural Science Project of Hebei North University(No.XJ2024034 and XJ2024035);Medical Science Research Subject Plan Project of Hebei Provincial Health Commission(No.20240782);Project of Administration of Traditional Chinese Medicine of Hebei Province(No.2025392);The 2025 Government-funded Training Project for Outstanding Clinical Medicine Talents(No.ZF2025264);Research Project of Medical Innovation for Chinese Youth(Project Leader:Jun Xue).g Project for Outstanding Clinical Medicine Talents(No.ZF2025264);Research Project of Medical Innovation for Chinese Youth(Project Leader:Jun Xue)。
The structure of intestinal tissue is complex.In vitro simulation of intestinal structure and function is important for studying intestinal development and diseases.Recently,organoids have been successfully constructe...
关键词：3D culture Colorectal cancer Disease model Intestinal organoids Organ transplantation Pluripotent stem cells Regenerative medicine Tumor organoids 
Establishment of human cerebral organoid systems to model early neural development and assess the central neurotoxicity of environmental toxins
《Neural Regeneration Research》2025年第1期242-252,共11页Daiyu Hu Yuanqing Cao Chenglin Cai Guangming Wang Min Zhou Luying Peng Yantao Fan Qiong Lai Zhengliang Gao 
supported by the National Key R&D Program of China,No.2019YFA0110300(to ZG);the National Natural Science Foundation of China,Nos.81773302(to YF),32070862(to ZG).
Human brain development is a complex process,and animal models often have significant limitations.To address this,researchers have developed pluripotent stem cell-derived three-dimensional structures,known as brain-li...
关键词：cadmium cell death cell proliferation cortical development environmental toxins neural progenitor cells NEUROGENESIS NEUROTOXICOLOGY ORGANOIDS stem cells 
Organoids:the future of disease modelling and therapeutics
《Biomaterials Translational》2024年第4期335-336,共2页Dongyang Zhou Zhidao Xia Jiacan Su 
In the rapidly advancing field of biomedical research,organoid technology has been a groundbreaking development.Organoids-three-dimensional structures derived from stem cells that replicate key structural and function...
关键词：ORGANS development. BREAKING 
Model construction and clinical therapeutic potential of engineered cardiac organoids for cardiovascular diseases被引量：1
《Biomaterials Translational》2024年第4期337-354,共18页Yongtao Wang Yan Hou Tian Hao Marta Garcia-Contreras Guoping Li Dragos Cretoiu Junjie Xiao 
supported by National Natural Science Foundation of China(No.82302401 to YW);the grant from Science and Technology Commission of Shanghai Municipality(Nos.23410750100,20DZ2255400 and 21XD1421300 to JX);the“Dawn”Program of Shanghai Education Commission(No.19SG34 to JX).
Cardiovascular diseases cause significant morbidity and mortality worldwide.Engineered cardiac organoids are being developed and used to replicate cardiac tissues supporting cardiac morphogenesis and development.These...
关键词：cardiac organoids cardiovascular diseases clinical applications scaffolds SELF-ASSEMBLY 
Progress in spinal cord organoid research:advancing understanding of neural development,disease modelling,and regenerative medicine被引量：1
《Biomaterials Translational》2024年第4期355-371,共17页Ruiqi Huang Yanjing Zhu Haokun Chen Liqun Yu Zhibo Liu Yuchen Liu Zhaojie Wang Xiaolie He Li Yang Xu Xu Yuxin Bai Bairu Chen Rongrong Zhu 
financially supported by the National Science Fund for Distinguished Young Scholars(No.82225027);the National Key Research and Development Program(No.2021YFA1101301);the National Natural Science Foundation of China(Nos.82271419,82202702,82202351,82001308,and 82271418);Shanghai Rising-Star Program(No.22QA1408200).
Stem cell-derived spinal cord organoids(SCOs)have revolutionised the study of spinal cord development and disease mechanisms,offering a three-dimensional model that recapitulates the complexity of native tissue.This r...
关键词：disease modelling NEURODEVELOPMENT regenerative medicine spinal cord organoids stem cells 
Revolutionising oral organoids with artificial intelligence被引量：1
《Biomaterials Translational》2024年第4期372-389,共18页Jiawei Yang Nicholas G.Fischer Zhou Ye 
supported by the IADR Innovation in Oral Care Awards,the Innovation and Technology Fund(No.ITS/307/22);the National Natural Science Foundation of China(NSFC)Young Scientist Fund(No.82401187).
The convergence of organoid technology and artificial intelligence(AI)is poised to revolutionise oral healthcare.Organoids-three-dimensional structures derived from human tissues-offer invaluable insights into the com...
关键词：artificial intelligence BIOPRINTING dental stem cells machine learning oral disease oral organoids 
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