Progress in spinal cord organoid research:advancing understanding of neural development,disease modelling,and regenerative medicine  

作　　者：Ruiqi Huang Yanjing Zhu Haokun Chen Liqun Yu Zhibo Liu Yuchen Liu Zhaojie Wang Xiaolie He Li Yang Xu Xu Yuxin Bai Bairu Chen Rongrong Zhu 

机构地区：[1]Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education,Department of Orthopedics,Tongji Hospital affiliated to Tongji University,School of Life Science and Technology,Tongji University,Shanghai,China [2]Frontier Science Center for Stem Cell Research,Tongji University,Shanghai,China [3]Clinical Center for Brain and Spinal Cord Research,Tongji University,Shanghai,China

出　　处：《Biomaterials Translational》2024年第4期355-371,共17页生物材料转化电子杂志（英文）

基　　金：financially supported by the National Science Fund for Distinguished Young Scholars(No.82225027);the National Key Research and Development Program(No.2021YFA1101301);the National Natural Science Foundation of China(Nos.82271419,82202702,82202351,82001308,and 82271418);Shanghai Rising-Star Program(No.22QA1408200).

摘　　要：Stem cell-derived spinal cord organoids(SCOs)have revolutionised the study of spinal cord development and disease mechanisms,offering a three-dimensional model that recapitulates the complexity of native tissue.This review synthesises recent advancements in SCO technology,highlighting their role in modelling spinal cord morphogenesis and their application in neurodegenerative disease research.We discuss the methodological breakthroughs in inducing regional specification and cellular diversity within SCOs,which have enhanced their predictive ability for drug screening and their relevance in mimicking pathological conditions such as neurodegenerative diseases and neuromuscular disorders.Despite these strides,challenges in achieving vascularisation and mature neuronal integration persist.The future of SCOs lies in addressing these limitations,potentially leading to transformative impactions in regenerative medicine and therapeutic development.

关 键 词：disease modelling NEURODEVELOPMENT regenerative medicine spinal cord organoids stem cells 

分 类 号：R318.1[医药卫生—生物医学工程]