supported by grants from the STI2030-Major Projects (2021ZD0204000);Key Strategic Science and Technology Cooperation Project (2023YFE0206800) of the Ministry of Science and Technology of China;the National Natural Science Foundation of China (81625006, 31820103005, 32000692);Zhejiang Province Natural Science Foundation of China (LZ24C090003 and LY21C090003);the Science and Technology Programme of Hangzhou Municipaility (20190101A10);the Key Realm R&D Program of Guangdong Province (2019B030335001);the Netherlands Organization for Scientific Research (NWO-ALW 824.02.001);the Dutch Organization for Medical Sciences (Zon MW 91120067);Medical Neuro-Delta (MD 01092019-31082023);INTENSE LSH-NWO (TTW/00798883);ERC-adv (GA-294775);ERC-POC (737619 and 768914)
The cerebellum is heavily connected with other brain regions,sub-serving not only motor but also nonmotor functions.Genetic mutations leading to cerebellar dysfunction are associated with mental diseases,but cerebella...
supported by the National Natural Science Fund of China(82374561,82174490,81873360);the Zhejiang Medical and Health Science and Technology Program(2021RC098);the Research Project of Zhejiang Chinese Medical University(2022JKZKTS44).
Objective:Electroacupuncture(EA)is an alternative treatment option for pain.Different frequencies of EA have different painrelieving effects;however,the central mechanism is still not well understood.Methods:The Fos2A...
supported by grants from the National Natural Science Foundation of China(32171014,31970940,31671100,31622027);the Zhejiang Provincial Natural Science Foundation of China(LR18H090001);the Non-profit Central Research Institute Fund of the Chinese Academy of Medical Sciences(2018PT31041);the Program for Introducing Talents in Discipline to Universities,the Fundamental Research Funds for Central Universities(2021FZZX001-37).
While somatosensory over-reactivity is a common feature of autism spectrum disorders such as fragile X syndrome(FXS),the thalamic mechanisms underlying this remain unclear.Here,we found that the developmental eliminat...
the Beijing Municipal Science&Technology Commission(Grant No.D171100003017002);National Key R&D Program of China(Grant No.2018YFC1312903);Strategic Priority Research Program of the Chinese Academy of Sciences(XDB39000000);National Science and Technology Major Project(Grant No.2017ZX09304018).
Background Small subcortical infarcts account for up to 25%of ischaemic strokes.Thalamus is one of the subcortical structures that commonly manifest with lacunar infarcts on MRI of the brain.Studies have shown that th...
supported by the National Natural Science Foundation of China(32030050 and 32192413);Guangdong High Level Innovation Research Institute(2021B0909050004);CAMS Innovation Fund for Medical Sciences(2019-I2M-5-082),and Shenzhen Sanming Project.
Nociceptive signals are usually transmitted to layer 4 neurons in somatosensory cortex via the spinothalamic-thalamocortical pathway.The layer 5 corticospinal neurons in sensorimotor cortex are reported to receive the...
Our general understanding of the function of neurons is that dendrites receive information that is relayed to the axon, where action potentials are initiated and propagated to eventually trigger neurotransmitter relea...
the Frontier Research Program of Biol and Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory)(2018GZR110105006);the National Natural ScienceFoundation of China(31900735,82171492,and 81922024);the Science,Technology and Innovation Commission of Shenzhen Municipality(RCJC 20200714114556103 and ZDSYS20190902093601675).
Dear Editor,Alzheimer's disease(AD)is one of the most devastating neurodegenerative disorders and the most common form of dementia.Synaptic loss is a hallmark of AD pathology and exacerbates cognitive impairment[1].Sy...
National Natural Science Foundation of China(Grant/Award Number:81701326);National Key Research and Development Program of China(Grant/Award Number:2016YFC1307004);Multidisciplinary Team for Cognitive Impairment of Shanxi Science and Technology Innovation Training Team(Grant/Award Number:201705D131027);Special Project of Scientific Research Plan Talents of Shanxi Provincial Health Commission(Grant/Award Number:2020081);Shanxi Provincial Science and Technology Achievements Transformation and Guidance Project(Grant/Award Numbers:201904D131020,81971601);Shanxi Province Overseas Students Science and Technology Activity Funding Project(Grant/Award Number:20200038)。
Background:Schizophrenia(SCZ)is a complex psychiatric disorder associated with widespread alterations in the subcortical brain structure.Hemispheric asymmetries are a fundamental organizational principle of the human ...
supported by Beijing Municipal Health Commission of China,No.Jing2019-2(to TLW)。
Hypothermia is an important protective strategy against global cerebral ischemia following cardiac arrest.However,the mechanisms of hypothermia underlying the changes in different regions and connections of the brain ...
Supported by the Korean Mental Health Technology R&D Project,Ministry of Health&Welfare,Republic of Korea,No.HL19C0015;the Korea Health Technology R&D Project through the Korea Health Industry Development Institute;funded by the Ministry of Health&Welfare,Republic of Korea,No.HR18C0016.
BACKGROUND The thalamus plays a key role in filtering information and has extensive interconnectivity with other brain regions.A large body of evidence points to impaired functional connectivity(FC)of the thalamocorti...