Release of Endogenous Brain-derived Neurotrophic Factor into the Lateral Entorhinal Cortex from the Paraventricular Thalamus Ameliorates Social Memory Deficits in a Mouse Model of Alzheimer’s Disease  

作　　者：Yun‑Long Xu Lin Zhu Zi‑Jun Chen Xiao‑Fei Deng Pei‑Dong Liu Shan Li Bing‑Chun Lin Chuan‑Zhong Yang Wei Xu Kui-Kui Zhou Ying‑Jie Zhu 

机构地区：[1]Shenzhen Key Laboratory of Drug Addiction,Shenzhen Neher Neural Plasticity Laboratory,the Brain Cognition and Brain Disease Institute(BCBDI),Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences(CAS),Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions,Shenzhen 518055,China [2]University of Chinese Academy of Sciences,Beijing 100049,China [3]Department of Neonatology,Shenzhen Maternity&Child Healthcare Hospital,The First School of Clinical Medicine,Southern Medical University,Shenzhen 518055,China [4]The First Afliated Hospital,Sun Yat-sen University,Guangzhou 510080,China [5]Cheeloo College of Medicine,Shandong University,Jinan 250012,China [6]Faculty of Life and Health Sciences,Shenzhen Institute of Advanced Technology,CAS,Shenzhen 518055,China [7]CAS Center for Excellence in Brain Science and Intelligence Technology,CAS,Shanghai 200031,China [8]CAS Key Laboratory of Brain Connectome and Manipulation,BCBDI,Shenzhen Institute of Advanced Technology(SIAT),CAS,Shenzhen 518055,China

出　　处：《Neuroscience Bulletin》2022年第11期1425-1430,共6页神经科学通报（英文版）

基　　金：the Frontier Research Program of Biol and Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory)(2018GZR110105006);the National Natural ScienceFoundation of China(31900735,82171492,and 81922024);the Science,Technology and Innovation Commission of Shenzhen Municipality(RCJC 20200714114556103 and ZDSYS20190902093601675).

摘　　要：Dear Editor,Alzheimer's disease(AD)is one of the most devastating neurodegenerative disorders and the most common form of dementia.Synaptic loss is a hallmark of AD pathology and exacerbates cognitive impairment[1].Synaptic loss,unlike neuronal loss,is reversible due to the highly dynamic properties of synapses.

关 键 词：ALZHEIMER pathology IMPAIRMENT 

分 类 号：R749.5[医药卫生—神经病学与精神病学]