HYPOTHALAMUS

作品数：197被引量：365H指数：10
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Single-cell and spatial omics:exploring hypothalamic heterogeneity
《Neural Regeneration Research》2025年第6期1525-1540,共16页Muhammad Junaid Eun Jeong Lee Su Bin Lim 
supported by the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI);the Ministry of Health&Welfare,Republic of Korea (HR22C1734);the National Research Foundation (NRF) of Korea (2020R1A6A1A03043539,2020M3A9D8037604,2022R1C1C1004756)(to SBL);the NRF of Korea (2022R1C1C1005741 and RS-2023-00217595);the new faculty research fund of Ajou University School of Medicine (to EJL)。
Elucidating the complex dynamic cellular organization in the hypothalamus is critical for understanding its role in coordinating fundamental body functions. Over the past decade, single-cell and spatial omics technolo...
关键词：cellular diversity HYPOTHALAMUS multi-omics single-cell transcriptomics spatial transcriptomics 
Potential role of tanycyte-derived neurogenesis in Alzheimer's disease
《Neural Regeneration Research》2025年第6期1599-1612,共14页Guibo Qi Han Tang Jianian Hu Siying Kang Song Qin 
supported by the National Natural Science Foundation of China,Nos.31871477,32170971 (both to SQ);the Qing-Feng Scholar Research Foundation of Shanghai Medical College,Fudan University,No.QF2212 (to HT)。
Tanycytes, specialized ependymal cells located in the hypothalamus, play a crucial role in the generation of new neurons that contribute to the neural circuits responsible for regulating the systemic energy balance. T...
关键词：Alzheimer's disease blood–brain barrier ependymoglial cells HYPOTHALAMUS metabolic diseases neural stem cells NEUROGENESIS neuroinflammatory diseases NEURONS TANYCYTE 
Effect of moxibustion at Shenque(CV8)and Guanyuan(CV4)on TRPV1 channel in spinal dorsal horn and hypothalamus of dysmenorrhea rats
《Journal of Acupuncture and Tuina Science》2025年第2期117-125,共9页SUN Yanqiu LIANG Yulei WANG Di ZHAO Zhiguo YANG Liyun ZHANG Xuanping ZHANG Yan ZHANG Xuan XING Yanxue ZHOU Min WANG Xiaoyan LI Xinhua 
国家自然科学基金青年项目,No.82104740;河北省自然科学基金项目,No.H2022423368.
Objective:To investigate the effect of mild moxibustion on transient receptor potential vanilloid type 1(TRPV1)channel expression in primary dysmenorrhea(PD)rats and explore its mechanism in alleviating central pain s...
关键词：Moxa Stick Moxibustion Point Shenque(CV8) Point Guanyuan(CV4) DYSMENORRHEA ANALGESIA Central Nervous System Sensitization Transient Receptor Potential Vanilloid 1 Rats 
Effects of grain intervention on hypothalamic function and the metabolome of blood and milk in dairy cows
《Journal of Animal Science and Biotechnology》2024年第6期2543-2552,共10页Limei Lin Kaizhen Guo Huiting Ma Jiyou Zhang Zheng Lai Weiyun Zhu Shengyong Mao 
funded by Natural Science Foundation of China(32072755)。
Background The hypothalamus plays a crucial role in the health and productivity of dairy cows,yet studies on its fun ctionality and its impact on peripheral circulation in these animals are relatively scarce,particula...
关键词：BLOOD Grain-based diet HYPOTHALAMUS Metabolomics MILK Prostaglandin E_(2) TRANSCRIPTOMICS 
Qingfei Zhisou oral liquid(清肺止嗽口服液)alleviates fever-induced inflammation by regulating arachidonic acid and lysophospholipids metabolism and inhibiting hypothalamus transient receptor potential ion channels expression
《Journal of Traditional Chinese Medicine》2024年第5期954-962,共9页GAO Jiaming ZHANG Yehao Chen Yuanyuan JIN Long ZHAO Jianfeng GUO Hao FU Jianhua 
Beijing Traditional Chinese Medicine Foundation for Science and Technology(JJ-2020-78):Research on the Protection of Intellectual Property Rights of Traditional Chinese Medicine;Scientific and Technological Innovation Project of China Academy of Chinese Medical Sciences(CI2021A00912):Basic and Translational Research on the Application of Traditional Chinese Medicine;the Research Foundation of Major New Drug Creation,from the Ministry of Science and Technology of China(2018ZX09721003-009-022):Research on Key Technologies and Industrialization of Traditional Chinese Medicine Preparations for Children;National Natural Science Foundation of China(82074060):Study on the Effect of Tanyu Tongzhi Fang in Maintaining Vascular Homeostasis in the Treatment of Atherosclerosis。
OBJECTIVE:To explore how Qingfei Zhisou oral liquid(清肺止嗽口服液,QFZS)adjusts body temperature bias and the interaction of inflammatory factors levels and metabolomic differences.METHODS:Dry yeast was subcutaneously...
关键词：INFLAMMATION FEVER metabolomics transient receptor potential ion channels Qingfei Zhisou oral liquid 
Growth hormone promotes the reconstruction of injured axons in the hypothalamo-neurohypophyseal system
《Neural Regeneration Research》2024年第10期2249-2258,共10页Kai Li Zhanpeng Feng Zhiwei Xiong Jun Pan Mingfeng Zhou Weizhao Li Yichao Ou Guangsen Wu Mengjie Che Haodong Gong Junjie Peng Xingqin Wang Songtao Qi Junxiang Peng 
supported by the Guangdong Basic and Applied Basic Research Foundation,Nos.2021A1515011371 (to JP),2021A1515110290 (to YO),2020A1515110564 (to XW);2023A 1 515010150 (to MZ);Science and Technology Planning Project of Guangzhou,No.202102020977 (to ZF);the National Natural Science Foundation of China,Nos.82201516 (to YO) and 81900709 (to ZF);President Foundation of Nanfang Hospital,Southern Medical University,Nos.2019C001 (to MZ),2019C016 (to XW), 2021C045 (to YO)。
Previous studies have shown that growth hormone can regulate hypothalamic energy metabolism, stress, and hormone release. Therefore, growth hormone has great potential for treating hypothalamic injury. In this study, ...
关键词：arginine vasopressin growth hormone hypothalamo-neurohypophyseal system HYPOTHALAMUS injury insulin-like growth factor 1 OXYTOCIN regeneration 
Map activation of various brain regions using different frequencies of electroacupuncture ST36,utilizing the FosCreER strategy
《Acupuncture and Herbal Medicine》2024年第3期386-398,共13页Zi Guo Naixuan Wei Ru Ye Tiancheng Sun Shuang Qiu Xiaomei Shao Xiaochang Ge Lu Guan Junfan Fang Jianqiao Fang Junying Du 
supported by the National Natural Science Fund of China(82374561,82174490,81873360);the Zhejiang Medical and Health Science and Technology Program(2021RC098);the Research Project of Zhejiang Chinese Medical University(2022JKZKTS44).
Objective:Electroacupuncture(EA)is an alternative treatment option for pain.Different frequencies of EA have different painrelieving effects;however,the central mechanism is still not well understood.Methods:The Fos2A...
关键词：AMYGDALA CORTEX EA-TRAPed neurons ELECTROACUPUNCTURE Frequency HYPOTHALAMUS THALAMUS 
Oxytocinergic Control of a Hypothalamic Social Fear Circuitry
《Neuroscience Bulletin》2024年第9期1399-1401,共3页Junqiang Zheng Xingying Wu Han Xu 
National Natural Science Foundation of China(32125018 and 32071005);Zhejiang Provincial Natural Science Foundation of China(LD24H090002);National Key Research and Development Program of China(2021YFA1101701);Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences(2023-PT310-01);Nanhu Brain-computer Interface Institute(010904008);MOE Frontiers Science Center for Brain Science&Brain-Machine Integration of Zhejiang University.
Exhibiting appropriate social behavior toward conspecifics is crucial for survival within a social group.For instance,after a conflict,it is essential for the loser to stay away from the victor to avoid further harm[1...
关键词：MEDIAL HYPOTHALAMUS PRECISE 
Hypothalamic circuits and aging:keeping the circadian clock updated被引量：1
《Neural Regeneration Research》2024年第9期1919-1928,共10页Rosa Vázquez-Lizarraga Lucia Mendoza-Viveros Carolina Cid-Castro Sareni Ruiz-Montoya Erick Carreño-Vázquez Ricardo Orozco-Solis 
supported by National Council of Science and Technology(CONACYT)(grants FC 2016/2672 and FOSISS 272757),INMEGEN(09/2017/I);the Ministry of Education,Science,Technology and Innovation of Mexico City(SECTEI)(grant 228/2021).
Over the past century,age-related diseases,such as cancer,type-2 diabetes,obesity,and mental illness,have shown a significant increase,negatively impacting overall quality of life.Studies on aged animal models have un...
关键词：AGING ASTROCYTES cellular stress responses circadian clock HYPOTHALAMUS intranasal drug administration metabolic control nutrient sensor SIRT1 sleep homeostasis 
Construction of an intranasal drug delivery system with hypothalamus-targeting nanoparticles
《SusMat》2024年第4期65-76,共12页Qianru Rao Yujie Xu Xiaorong Wang Hang Luo Haoqi Li Jingyuan Xiong Huile Gao Guo Cheng 
National Natural Science Foundation of China,Grant/Award Numbers:82173512,82304135。
Dysfunction of the hypothalamus is associated with endocrine imbalances,growth abnormalities,and reproductive disorders.However,there is a lack of targeted treatment strategies focused on the hypothalamus.In this stud...
关键词：HYPOTHALAMUS intranasal delivery NANOPARTICLES neurokinin receptor 3 
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