NEUROPATHOLOGY

作品数：61被引量：145H指数：7
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Cerebellar microglia:On the edge between neuroinflammation and neuroregulation
《Neural Regeneration Research》2026年第1期156-172,共17页Marina SDukhinova Jingwen Guo Enwei Shen Wanting Liu Wanqi Huang Ying Shen Luxi Wang 
supported by grants from STI2030-Major Projects,No.2021ZD0204000(to YS);Key Strategic Science and Technology Cooperation Project of the Ministry of Science and Technology of China,No.SQ2023YFE0201430(to YS);the National Natural Science Foundation of China,Nos.31820103005(to YS),32200620(to LW);the Natural Science Foundation of Zhejiang Province of China,No.LZ24C090003(to YS)。
The cerebellum is receiving increasing attention for its cognitive,emotional,and social functions,as well as its unique metabolic profiles.Cerebellar microglia exhibit specialized and highly immunogenic phenotypes und...
关键词：brain regeneration cerebellar diseases CEREBELLUM innate immunity macrophages metabolism MICROGLIA NEUROINFLAMMATION NEUROPATHOLOGY Purkinje cells 
Adeno-associated viral vectors for modeling Parkinson's disease in non-human primates
《Neural Regeneration Research》2026年第1期224-232,共9页Julia Chocarro JoséL.Lanciego 
supported by grants PID2020-120308RB-I00 and PID2023-147802OB-I00 funded by MICIU/AEI/10.13039/501100011033;FEDER,UE,by Aligning Science Across Parkinson’s(ref.ASAP-020505)through the Michael J.Fox Foundation for Parkinson’s Research;by CiberNed Intramural Collaborative Projects(ref.PI2020/09);by the Spanish Fundación Mutua Madrile?a de Investigación Médica(to JLL)。
The development of clinical candidates that modify the natural progression of sporadic Parkinson's disease and related synucleinopathies is a praiseworthy endeavor,but extremely challenging.Therapeutic candidates that...
关键词：adeno-associated viral vectors ALPHA-SYNUCLEIN DOPAMINE Lewy bodies NEURODEGENERATION NEUROMELANIN NEUROPATHOLOGY substantia nigra 
Misfolded amyloid-beta conformational variants(strains)as drivers of Alzheimer's disease neuropathology
《Neural Regeneration Research》2025年第11期3219-3220,共2页Salvatore Saieva Rodrigo Morales 
supported by a grant from NIH(R01AI132695)to RM。
Pathological and clinical variability in Alzheimer's disease(AD):AD is clinically cha racterized by progressive memory loss and cognitive impairment.From a pathological point of view,the main features of AD are the de...
关键词：AMYLOID ALZHEIMER clinical 
Synergistic effects of IL-3 release and Mn^(2+)-doped Prussian blue nanoparticles camouflaged with MES23.5 cell membranes on Alzheimer’s disease therapy
《Nano Research》2025年第2期594-606,共13页Tuodi Zhang Zhonghui Xue Qianqian He Junling Yang Ya Wen Xiaohui Lu Min Xu Yuehua Guo 
This work was supported by Jiangsu Provincial Research Hospital(No.YJXYY202204);Science and Technology Project of Nantong City(No.MS2023006).
Alzheimer'sdisease(AD)isaprogressive neurodegenerative disorder with prolonged latency during the prodromal stage.However,current clinical approaches to pharmacological interventions for AD remain challenge.An effecti...
关键词：Alzheimer's disease NEUROINFLAMMATION brain-targeted drug delivery tau neuropathology reactive oxygen species 
Human dental pulp stem cells mitigate the neuropathology and cognitive decline via AKT-GSK3β-Nrf2 pathways in Alzheimer's disease
《International Journal of Oral Science》2024年第4期657-670,共14页Wei Xiong Ye Liu Heng Zhou Junyi Li Shuili Jing Cailei Jiang Mei Li Yan He Qingsong Ye 
supported by the key R&D Program of Hubei Province of China(YFXM2022000264);key Project of Ministry of Science and Technology China(2022YFC2504200);National Natural Science Foundation of China(U22A20314);Chutian Researcher Project(X22020024).
Oxidative stress is increasingly recognized as a major contributor to the pathophysiology of Alzheimer's disease(AD),particularly in the early stages of the disease.The multiplicity advantages of stem cell transplanta...
关键词：protective ALZHEIMER NRF2 
Unilateral rNurr1-V5 transgene expression in nigral dopaminergic neurons mitigates bilateral neuropathology and behavioral deficits in parkinsonian rats withα-synucleinopathy被引量：1
《Neural Regeneration Research》2024年第9期2057-2067,共11页Bismark Gatica-Garcia Michael J.Bannon Irma Alicia Martínez-Dávila Luis O.Soto-Rojas David Reyes-Corona Lourdes Escobedo Minerva Maldonado-Berny ME Gutierrez-Castillo Armando J.Espadas-Alvarez Manuel A.Fernandez-Parrilla Juan U.Mascotte-Cruz CP Rodríguez-Oviedo Irais E.Valenzuela-Arzeta Claudia Luna-Herrera Francisco E.Lopez-Salas Jaime Santoyo-Salazar Daniel Martinez-Fong 
Parkinsonism by unilateral,intranigralβ-sitosterolβ-D-glucoside administration in rats is distinguished in that theα-synuclein insult begins unilaterally but spreads bilaterally and increases in severity over time,...
关键词：A1 astrocytes A2 astrocytes gene therapy microglia motor deficits nanoparticles neurodegeneration neuroinflammation senescence α-synuclein aggregates 
Terahertz Irradiation Improves Cognitive Impairments and Attenuates Alzheimer’s Neuropathology in the APP^(SWE)/PS1^(DE9) Mouse:A Novel Therapeutic Intervention for Alzheimer’s Disease
《Neuroscience Bulletin》2024年第7期857-871,共15页Jun Zhang Yixin Chen Yarui Zhao Panpan Wang Hongbin Ding Cong Liu Junhong Lyu Weidong Le 
supported by the National Natural Science Foundation of China(32220103006 and 82271524).
Alzheimer's disease(AD)is a progressive neurodegenerative disease characterized by the deposition of amyloid-β(Aβ),neurofibrillary tangles,neuroinflammation,and neurodegeneration in the brain.In recent years,conside...
关键词：Alzheimer's disease Cognitive impairment Senile plaque Tau protein TERAHERTZ 
Gut dysbiosis aggravates cognitive deficits,amyloid pathology and lipid metabolism dysregulation in a transgenic mouse model of Alzheimer's disease
《Journal of Pharmaceutical Analysis》2023年第12期1526-1547,共22页Chang Qu Qing-Qing Xu Wen Yang Mei Zhong Qiuju Yuan Yan-Fang Xian Zhi-Xiu Lin 
This work was partially supported by National Natural Science Foundation of China(Project No.:82104414);Natural Science Foundation of Guangdong Province of China(Project No.:2022A1515011682);a direct grant from The Chinese University of Hong Kong(Project No.:2021.071).
Gut dysbiosis,a well-known risk factor to triggers the progression of Alzheimer's disease(AD),is strongly associated with metabolic disturbance.Trimethylamine N-oxide(TMAO),produced in the dietary choline metabolism,h...
关键词：Alzheimer's disease Gut dysbiosis NEUROPATHOLOGY TgCRND8 mice 
Security breach:peripheral nerves provide unrestricted access for toxin delivery into the central nervous system
《Neural Regeneration Research》2023年第1期64-67,共4页Igor Lupinski Allison SLiang Randall D.McKinnon 
supported by grants from the New Jersey Commission on Spinal Cord Research (05-3047;11-015)
We explore the hypothesis that a potential explanation for the initiation of motor neuron disease is an unappreciated vulnerability in central nervous system defense,the direct delivery of neurotoxins into motor neuro...
关键词：amyotrophic lateral sclerosis BIOACCUMULATION NEURODEGENERATION NEUROPATHOLOGY NEUROTOXINS peripheral nerves retrograde transport retrotoxicity suicide transport 
Molecular Neuropathology versus Histopathology in the Diagnosis of Central Nervous System Tumors: Review Article about Novel Diagnostic and Investigative Technologies
《Journal of Biosciences and Medicines》2022年第12期55-72,共18页Saad Misfer Alqahtani 
Background: While the diagnostic roles of histopathology and cytopathology remain highly significant nowadays, the roles and applications of molecular techniques in neuropathology are expanding and becoming noteworthy...
关键词：CNS TUMORS METHYLATION Spatial Transcriptomics HISTOPATHOLOGY MOLECULAR 
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