NEUROTOXINS

作品数：16被引量：30H指数：4
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相关领域：医药卫生生物学更多>>
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相关机构：中国科学院更多>>
相关期刊：《Bioactive Materials》《中国临床神经科学》《Journal of Biosciences and Medicines》《Acta Pharmacologica Sinica》更多>>
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A genetically engineered neuronal membrane-based nanotoxoid elicits protective immunity against neurotoxins
《Bioactive Materials》2024年第8期321-330,共10页Zhongyuan Guo Audrey T.Zhu Xiaoli Wei Yao Jiang Yiyan Yu Ilkoo Noh Weiwei Gao Ronnie H.Fang Liangfang Zhang 
supported by the Defense Threat Reduction Agency Joint Science and Technology Office for Chemical and Biological Defense under award number HDTRA1-21-1-0010;the National Institutes of Health under Award Numbers R21AI159492 and R21AI175904.
Given their dangerous effects on the nervous system,neurotoxins represent a significant threat to public health.Various therapeutic approaches,including chelating agents,receptor decoys,and toxin-neutralizing antibodi...
关键词：Antivirulence vaccine Cell membrane-coated nanoparticle Genetic engineering Α-BUNGAROTOXIN Nanotoxoid 
Single-neuron neurodegeneration as a degenerative model for Parkinson’s disease被引量：2
《Neural Regeneration Research》2024年第3期529-535,共7页Sandro Huenchuguala Juan Segura-Aguilar 
The positive effect of levodopa in the treatment of Parkinson’s disease,although it is limited in time and has severe side effects,has encouraged the scientific community to look for new drugs that can stop the neuro...
关键词：1-methyl-4-phenyl-1 2 3 6-tetrahydropyridine 6-HYDROXYDOPAMINE aminochrome dopaminergic neurons DT-diaphorase exogenous neurotoxins glutathione transferase M2-2 
Genomic,transcriptomic,and epigenomic analysis of a medicinal snake,Bungarus multicinctus,to provides insights into the origin of Elapidae neurotoxins被引量：1
《Acta Pharmaceutica Sinica B》2023年第5期2234-2249,共16页Jiang Xu Shuai Guo Xianmei Yin Mingqian Li He Su Xuejiao Liao Qiushi Li Liang Le Shiyu Chen Baosheng Liao Haoyu Hu Juan Lei Yingjie Zhu Xiaohui Qiu Lu Luo Jun Chen Ruiyang Cheng Zhenzhan Chang Han Zhang Nicholas Chieh Wu Yiming Guo Dianyun Hou Jin Pei Jihai Gao Yan Hua Zhihai Huang Shilin Chen 
the Fundamental Research Funds for the Central Public Welfare Research Institutes(ZZ13-YQ-047,ZXKT22006,China);quality standard system construction for the whole industry chain of Chinese medicine from Guangdong Provincial Drug Administration of China(002009/2019KT1261/2020ZDB25);the National Major Science and Technology Projects(2019ZX09201005,China);the Open Research Fund of Chengdu University of Traditional Chinese Medicino state Key Laboratory scluthwestern Chinese Medicine Resources(2022ZYXK2011006,China);the National Key R&D Program of China(2019YFC1711100)。
The many-banded krait,Bungarus multicinctus,has been recorded as the animal resource of JinQianBaiHuaShe in the Chinese Pharmacopoeia.Characterization of its venoms classified chief phyla of modern animal neurotoxins....
关键词：Medicinal snake Neurotoxin origin ANTIVENOMS Gene regulation Chromatin 
Relative Molecular Similarity in Compound Structures Modulating Neurodegenerative Apoptosis
《Journal of Biosciences and Medicines》2023年第2期105-123,共19页Wynford Robert Williams 
Neurodegeneration is attributable to metabolic disturbances in the various cell types responsible for this condition, in respect of glucose utilisation and dysfunctional mitochondrial oxidative mechanisms. The propert...
关键词：APOPTOSIS CGMP NEURODEGENERATION NEUROTOXINS Molecular Similarity 
Security breach:peripheral nerves provide unrestricted access for toxin delivery into the central nervous system
《Neural Regeneration Research》2023年第1期64-67,共4页Igor Lupinski Allison SLiang Randall D.McKinnon 
supported by grants from the New Jersey Commission on Spinal Cord Research (05-3047;11-015)
We explore the hypothesis that a potential explanation for the initiation of motor neuron disease is an unappreciated vulnerability in central nervous system defense,the direct delivery of neurotoxins into motor neuro...
关键词：amyotrophic lateral sclerosis BIOACCUMULATION NEURODEGENERATION NEUROPATHOLOGY NEUROTOXINS peripheral nerves retrograde transport retrotoxicity suicide transport 
High-fat diet causes increased endogenous neurotoxins and phenotype of Parkinson’s disease in mice被引量：1
《Acta Biochimica et Biophysica Sinica》2019年第9期969-971,共3页Hanyan Wu Bingjie Xie Ming Ke Yulin Deng 
Clinical data showed that patients with type 2 diabetes(T2D)are more likely to develop Parkinson’s disease(PD)than normal people[1].Particularly when patients are in the early stage of T2D,their risk of PD is seven t...
关键词：ENDOGENOUS metabolism PEROXIDATION 
Fungal-contaminated grass and well water and sporadic amyotrophic lateral sclerosis被引量：1
《Neural Regeneration Research》2019年第9期1490-1493,共4页Peter William French Russell Ian Ludowyke Gilles J.Guillemin 
Fungi are important infectious disease-causing agents,but are often overlooked as environmental factors in disease.We review several lines of evidence that point to a potential fungal origin of sporadic amyotrophic la...
关键词：amyotrophic lateral SCLEROSIS fungi motor NEURONE disease mycotoxins NEUROTOXINS ALS well water SPORADIC ALS 
Genomic bases of scallop adaptation to semi-sessile life and neurotoxins
《Science Foundation in China》2018年第2期39-39,共1页
With the support by the National Natural Science Foundation of China,a research team led by Prof.Bao ZhenMin(包振民)and Wang Shi(王师)from the Key Laboratory of Marine Genetics and Breeding(Ministry of Education),Ocea...
关键词：神经毒素 改编 扇贝 生活 海洋大学 生物信息学 科学基础 研究人员 
On the role of endogenous neurotoxins and neuroprotection in Parkinson's disease被引量：5
《Neural Regeneration Research》2017年第6期897-901,共5页Juan Segura-Aguilar 
supported by FONDECYT 1170033
For 50 years ago was introduced L-3,4-dihydroxyphenylalanine（L-dopa） in Parkinson＇s disease treatment and during this significant advances has been done but what trigger the degeneration of the nigrostriatal system...
关键词：dopamine endogenous endoplasmic degeneration reticulum extremely glutathione Dopamine transporter metabolism 
The microbiome,microbial-generated proinflammato y neurotoxins,and Alzheimer's disease被引量：5
《Journal of Sport and Health Science》2016年第4期393-396,共4页Walter J.Lukiw 
the Society for Neuroscience Annual Meeting,October 17–21,2015,Chicago,IL,USA;the Association for Research in Vision and Ophthalmology Annual Conference,May 1–5,2016,Seattle,WA,USA;the Scientifi Committee of Aging and Antiaging,Gerontological Society of China,May 6–8,2016,Shanghai,China;an unrestricted grant to the LSU Eye Center from Research to Prevent Blindness;the Louisiana Biotechnology Research Network;National Institutes of Health grants NEI EY006311,NIA AG18031,and NIA AG038834
1.Overview Genomic sequencing studies indicate that the human gastrointestinal（GI）tract is a dynamic repository of about-10^14 micro-organisms that outnumber host cells by at least 100 to 1.
关键词：GI BFT 
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